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Article: Natural history of dengue virus (DENV)-1 and DENV-4 infections: Reanalysis of classic studies

TitleNatural history of dengue virus (DENV)-1 and DENV-4 infections: Reanalysis of classic studies
Authors
Issue Date2007
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2007, v. 195 n. 7, p. 1007-1013 How to Cite?
AbstractBackground. The natural history of wild-type dengue virus (DENV) infections of humans, including incubation and infectious periods, requires further study. Methods. Two experimental studies in the Philippines of DENV-4 (1924-1925) and DENV-1 (1929-1930) were reexamined. The intrinsic incubation periods were fitted to log-normal distribution using the maximum likelihood method, and the infectious and extrinsic incubation periods were assessed by proportions of successful transmissions causing clinically apparent dengue. Correlations between the intrinsic incubation period and other variables and univariate associations between clinical severity and serotype were also examined. Results. Mean ± SD incubation periods were 6.0 ± 1.4 and 5.7 ± 1.5 days for DENV-4 and DENV-1, respectively. Significant negative correlations were observed between the incubation period and duration of fever (r = -0.43 and -0.33). Even 1 and 2 days before the onset of fever, 80.0% (95% confidence interval [CI], 44.9%-100%) and 25.0% (CI, 0%-67.4%) of biting experiments caused clinically apparent dengue. DENV-1 infections resulted in a significantly longer duration of fever than DENV-4 infections (P<.01). Conclusions. Incubation period was negatively correlated with disease severity, potentially reflecting a dose-response mechanism. The historical data provided useful details concerning serotype differences in the natural history of primary DENV infections. © 2007 by the Infectious Diseases Society of America. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/134225
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNishiura, Hen_HK
dc.contributor.authorHalstead, SBen_HK
dc.date.accessioned2011-06-13T07:20:55Z-
dc.date.available2011-06-13T07:20:55Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Infectious Diseases, 2007, v. 195 n. 7, p. 1007-1013en_HK
dc.identifier.issn0022-1899en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134225-
dc.description.abstractBackground. The natural history of wild-type dengue virus (DENV) infections of humans, including incubation and infectious periods, requires further study. Methods. Two experimental studies in the Philippines of DENV-4 (1924-1925) and DENV-1 (1929-1930) were reexamined. The intrinsic incubation periods were fitted to log-normal distribution using the maximum likelihood method, and the infectious and extrinsic incubation periods were assessed by proportions of successful transmissions causing clinically apparent dengue. Correlations between the intrinsic incubation period and other variables and univariate associations between clinical severity and serotype were also examined. Results. Mean ± SD incubation periods were 6.0 ± 1.4 and 5.7 ± 1.5 days for DENV-4 and DENV-1, respectively. Significant negative correlations were observed between the incubation period and duration of fever (r = -0.43 and -0.33). Even 1 and 2 days before the onset of fever, 80.0% (95% confidence interval [CI], 44.9%-100%) and 25.0% (CI, 0%-67.4%) of biting experiments caused clinically apparent dengue. DENV-1 infections resulted in a significantly longer duration of fever than DENV-4 infections (P<.01). Conclusions. Incubation period was negatively correlated with disease severity, potentially reflecting a dose-response mechanism. The historical data provided useful details concerning serotype differences in the natural history of primary DENV infections. © 2007 by the Infectious Diseases Society of America. All rights reserved.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org en_HK
dc.relation.ispartofJournal of Infectious Diseasesen_HK
dc.subject.meshDengue - epidemiology - history - transmissionen_HK
dc.subject.meshDengue Virus - classification - isolation & purificationen_HK
dc.subject.meshDisease Transmission, Infectious - historyen_HK
dc.subject.meshHistory, 20th Centuryen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMilitary Personnel - history - statistics & numerical dataen_HK
dc.subject.meshPhilippines - epidemiologyen_HK
dc.subject.meshSeverity of Illness Indexen_HK
dc.subject.meshTime Factorsen_HK
dc.titleNatural history of dengue virus (DENV)-1 and DENV-4 infections: Reanalysis of classic studiesen_HK
dc.typeArticleen_HK
dc.identifier.emailNishiura, H:nishiura@hku.hken_HK
dc.identifier.authorityNishiura, H=rp01488en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1086/511825en_HK
dc.identifier.pmid17330791-
dc.identifier.scopuseid_2-s2.0-33947388015en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33947388015&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume195en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1007en_HK
dc.identifier.epage1013en_HK
dc.identifier.isiWOS:000244721700014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNishiura, H=7005501836en_HK
dc.identifier.scopusauthoridHalstead, SB=7005704809en_HK

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