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Article: Infectiousness of smallpox relative to disease age: Estimates based on transmission network and incubation period

TitleInfectiousness of smallpox relative to disease age: Estimates based on transmission network and incubation period
Authors
KeywordsReferences (31) View In Table Layout
Issue Date2007
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYG
Citation
Epidemiology And Infection, 2007, v. 135 n. 7, p. 1145-1150 How to Cite?
AbstractThis study investigated the infectiousness of smallpox relative to the onset of fever using a likelihood-based estimation procedure based on the observed transmission network (n=223) and on the distribution of the incubation period (n=379). Who-infected-whom information enabled us to back-calculate the infectiousness by disease age, employing a step function model for infectiousness. Frequency of secondary transmissions was highest between 3 and 6 days after onset of fever, yielding an expected daily frequency of 20.6% (95% CI 15.1-26.4) of the total number of secondary transmissions, which is consistent with previous observations. The estimated cumulative frequency suggests that 91.1% of secondary transmissions occurred up to 9 days after onset of fever. The proposed method appeared to be useful for diseases with an acute course of illness, where transmission was not hampered by depletion of susceptible contacts. © 2006 Cambridge University Press.
Persistent Identifierhttp://hdl.handle.net/10722/134221
ISSN
2015 Impact Factor: 2.515
2015 SCImago Journal Rankings: 1.320
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNishiura, Hen_HK
dc.contributor.authorEichner, Men_HK
dc.date.accessioned2011-06-13T07:20:54Z-
dc.date.available2011-06-13T07:20:54Z-
dc.date.issued2007en_HK
dc.identifier.citationEpidemiology And Infection, 2007, v. 135 n. 7, p. 1145-1150en_HK
dc.identifier.issn0950-2688en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134221-
dc.description.abstractThis study investigated the infectiousness of smallpox relative to the onset of fever using a likelihood-based estimation procedure based on the observed transmission network (n=223) and on the distribution of the incubation period (n=379). Who-infected-whom information enabled us to back-calculate the infectiousness by disease age, employing a step function model for infectiousness. Frequency of secondary transmissions was highest between 3 and 6 days after onset of fever, yielding an expected daily frequency of 20.6% (95% CI 15.1-26.4) of the total number of secondary transmissions, which is consistent with previous observations. The estimated cumulative frequency suggests that 91.1% of secondary transmissions occurred up to 9 days after onset of fever. The proposed method appeared to be useful for diseases with an acute course of illness, where transmission was not hampered by depletion of susceptible contacts. © 2006 Cambridge University Press.en_HK
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYGen_HK
dc.relation.ispartofEpidemiology and Infectionen_HK
dc.subjectReferences (31) View In Table Layouten_US
dc.titleInfectiousness of smallpox relative to disease age: Estimates based on transmission network and incubation perioden_HK
dc.typeArticleen_HK
dc.identifier.emailNishiura, H:nishiura@hku.hken_HK
dc.identifier.authorityNishiura, H=rp01488en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1017/S0950268806007618en_HK
dc.identifier.pmid17156499-
dc.identifier.pmcidPMC2870668-
dc.identifier.scopuseid_2-s2.0-34249827453en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34249827453&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume135en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1145en_HK
dc.identifier.epage1150en_HK
dc.identifier.eissn1469-4409-
dc.identifier.isiWOS:000250941800013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridNishiura, H=7005501836en_HK
dc.identifier.scopusauthoridEichner, M=26643365500en_HK

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