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Article: Interpreting the epidemiology of postexposure vaccination against smallpox

TitleInterpreting the epidemiology of postexposure vaccination against smallpox
Authors
KeywordsSpecies Index: Variola
Variola Virus
Issue Date2008
PublisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/intjhyg
Citation
International Journal Of Hygiene And Environmental Health, 2008, v. 211 n. 1-2, p. 219-226 How to Cite?
AbstractSix historical studies were investigated to clarify the obtainable information on postexposure vaccination against smallpox. Using the distribution of incubation period, the frequency of cases by time from exposure to vaccination was obtained. More than half of all failures happened within 7 d after exposure in all six records investigated. Based on two studies (n=36 and 28), the probability of escaping severe smallpox was further analyzed using logistic regression, showing an inverse association between severe smallpox and time from vaccination to onset (p<0.01 and p=0.04, respectively). Whereas the relationship between the probability of developing severe disease and the time from vaccination to onset could be analyzed with the available information, our findings indicate that previous epidemiologic records showing cases alone, rather than also showing individuals probably protected, are not useful for clarifying the effectiveness of postexposure vaccination by time after exposure. © 2007 Elsevier GmbH. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/134217
ISSN
2015 Impact Factor: 3.98
2015 SCImago Journal Rankings: 1.499
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNishiura, Hen_HK
dc.contributor.authorEichner, Men_HK
dc.date.accessioned2011-06-13T07:20:53Z-
dc.date.available2011-06-13T07:20:53Z-
dc.date.issued2008en_HK
dc.identifier.citationInternational Journal Of Hygiene And Environmental Health, 2008, v. 211 n. 1-2, p. 219-226en_HK
dc.identifier.issn1438-4639en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134217-
dc.description.abstractSix historical studies were investigated to clarify the obtainable information on postexposure vaccination against smallpox. Using the distribution of incubation period, the frequency of cases by time from exposure to vaccination was obtained. More than half of all failures happened within 7 d after exposure in all six records investigated. Based on two studies (n=36 and 28), the probability of escaping severe smallpox was further analyzed using logistic regression, showing an inverse association between severe smallpox and time from vaccination to onset (p<0.01 and p=0.04, respectively). Whereas the relationship between the probability of developing severe disease and the time from vaccination to onset could be analyzed with the available information, our findings indicate that previous epidemiologic records showing cases alone, rather than also showing individuals probably protected, are not useful for clarifying the effectiveness of postexposure vaccination by time after exposure. © 2007 Elsevier GmbH. All rights reserved.en_HK
dc.languageengen_US
dc.publisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/intjhygen_HK
dc.relation.ispartofInternational Journal of Hygiene and Environmental Healthen_HK
dc.subjectSpecies Index: Variolaen_US
dc.subjectVariola Virusen_US
dc.subject.meshBioterrorismen_HK
dc.subject.meshDisaster Planningen_HK
dc.subject.meshEurope - epidemiologyen_HK
dc.subject.meshHistory, 19th Centuryen_HK
dc.subject.meshHistory, 20th Centuryen_HK
dc.subject.meshHumansen_HK
dc.subject.meshJapan - epidemiologyen_HK
dc.subject.meshLikelihood Functionsen_HK
dc.subject.meshLogistic Modelsen_HK
dc.subject.meshSmallpox - epidemiology - history - prevention & controlen_HK
dc.subject.meshSmallpox Vaccine - administration & dosage - immunologyen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshVaccination - history - methodsen_HK
dc.titleInterpreting the epidemiology of postexposure vaccination against smallpoxen_HK
dc.typeArticleen_HK
dc.identifier.emailNishiura, H:nishiura@hku.hken_HK
dc.identifier.authorityNishiura, H=rp01488en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ijheh.2007.01.029en_HK
dc.identifier.pmid17321212-
dc.identifier.scopuseid_2-s2.0-39049167017en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-39049167017&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume211en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage219en_HK
dc.identifier.epage226en_HK
dc.identifier.eissn1618-131X-
dc.identifier.isiWOS:000254304100026-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridNishiura, H=7005501836en_HK
dc.identifier.scopusauthoridEichner, M=26643365500en_HK

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