File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A simple mathematical approach to deciding the dosage of vaccine against pandemic H1N1 influenza.

TitleA simple mathematical approach to deciding the dosage of vaccine against pandemic H1N1 influenza.
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2009
Citation
Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, 2009, v. 14 n. 45 How to Cite?
AbstractResults from early clinical trials have shown that a single dose of pandemic H1N1 influenza vaccine may generate sufficient antibody response, but the relevance of this fact to public health decision making has yet to be clarified. The present study compares the risk of clinical attack (i.e. clinical attack rate) between one- and two-dose vaccination schemes. If the efficacies do not greatly vary between one- and two-dose schemes, one-dose vaccination may well be supported. Nevertheless, two-dose vaccination is shown to result in less morbidity if the vaccine efficacies are greatly diminished by reducing the dose. As long as the detailed efficacy estimates rest on theoretical assumptions, single-dose vaccination may only be sufficiently justified in a specific setting where the number of vaccines is extremely limited.
Persistent Identifierhttp://hdl.handle.net/10722/134204
ISSN
2015 Impact Factor: 5.983
2015 SCImago Journal Rankings: 2.112

 

DC FieldValueLanguage
dc.contributor.authorNishiura, Hen_HK
dc.contributor.authorIwata, Ken_HK
dc.date.accessioned2011-06-13T07:20:49Z-
dc.date.available2011-06-13T07:20:49Z-
dc.date.issued2009en_HK
dc.identifier.citationEuro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, 2009, v. 14 n. 45en_HK
dc.identifier.issn1560-7917en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134204-
dc.description.abstractResults from early clinical trials have shown that a single dose of pandemic H1N1 influenza vaccine may generate sufficient antibody response, but the relevance of this fact to public health decision making has yet to be clarified. The present study compares the risk of clinical attack (i.e. clinical attack rate) between one- and two-dose vaccination schemes. If the efficacies do not greatly vary between one- and two-dose schemes, one-dose vaccination may well be supported. Nevertheless, two-dose vaccination is shown to result in less morbidity if the vaccine efficacies are greatly diminished by reducing the dose. As long as the detailed efficacy estimates rest on theoretical assumptions, single-dose vaccination may only be sufficiently justified in a specific setting where the number of vaccines is extremely limited.en_HK
dc.languageengen_US
dc.relation.ispartofEuro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletinen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.subject.meshAlgorithmsen_HK
dc.subject.meshAntibodies, Viralen_HK
dc.subject.meshDisease Outbreaks - prevention & controlen_HK
dc.subject.meshDose-Response Relationship, Immunologicen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunity, Herden_HK
dc.subject.meshImmunization, Secondaryen_HK
dc.subject.meshInfluenza A Virus, H1N1 Subtype - immunologyen_HK
dc.subject.meshInfluenza Vaccines - administration & dosageen_HK
dc.subject.meshInfluenza, Human - epidemiology - prevention & control - transmission - virologyen_HK
dc.subject.meshMass Vaccinationen_HK
dc.subject.meshModels, Theoreticalen_HK
dc.subject.meshRisken_HK
dc.subject.meshVaccination - methodsen_HK
dc.titleA simple mathematical approach to deciding the dosage of vaccine against pandemic H1N1 influenza.en_HK
dc.typeArticleen_HK
dc.identifier.emailNishiura, H:nishiura@hku.hken_HK
dc.identifier.authorityNishiura, H=rp01488en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid19941790-
dc.identifier.scopuseid_2-s2.0-75549091704en_HK
dc.identifier.volume14en_HK
dc.identifier.issue45en_HK
dc.identifier.scopusauthoridNishiura, H=7005501836en_HK
dc.identifier.scopusauthoridIwata, K=35344754800en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats