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Article: Reconstructing an annual cycle of interaction: Natural infection and antibody dynamics to avian influenza along a migratory flyway

TitleReconstructing an annual cycle of interaction: Natural infection and antibody dynamics to avian influenza along a migratory flyway
Authors
Issue Date2011
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ECO
Citation
Oikos, 2011, v. 120 n. 5, p. 748-755 How to Cite?
AbstractMigratory animals may play an important role in connecting disparate ecosystems, including the introduction of various pathogens. The incidence of these pathogens may vary over time and space, such that events along the entire migratory flyway are likely to be important in the interaction between pathogens and their migratory hosts. On this premise, the annual cycle of a naturally occurring host-pathogen system was reconstructed by examining infection with and antibodies to avian influenza virus along the flyway of a long-distance Arctic migrant, the Svalbard-breeding pink-footed goose Anser brachyrhynchus. A highly-localized transmission period was identified in winter, in contrast to the north-south decline expected from dabbling ducks, indicating the dynamics of infection may differ among host species. In spring, 63% (95% CI: 57.1, 68.9) of adults had detectable antibodies to the nucleoprotein of avian influenza virus, compared to just 15% (95% CI: 8.7, 23.4) of juveniles, suggesting inter-annual antibody maintenance. Nevertheless, adult seroprevalence declined by approximately 30% from spring to late summer, indicating significant seroreversion in the population. Integrating these findings in an epidemiological model, detectable antibodies to nucleoprotein were estimated to persist for just 343 days (95% CI: 221, 607); considerably shorter than for other wildlife diseases in long-lived bird species. The investigation of wildlife diseases in migratory populations is an inherently complex task, yet, by integrating disease incidence and seroprevalence along a migratory flyway, our findings suggest that the ecological interactions and life history of the host, as well as the life-history of the pathogen, can influence the dynamics of infection and host immune response. © 2011 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/134179
ISSN
2015 Impact Factor: 3.586
2015 SCImago Journal Rankings: 2.473
ISI Accession Number ID
Funding AgencyGrant Number
Netherlands Organisation for Scientific Research (NWO)851.40.073
851.40.074
EU044490
NIAIDNIHHHSN266200700010C
JST PRESTO
Danish Forest and Nature Agency
Funding Information:

We would like to thank Pascal Lexmond and Chantal Baas for excellent laboratory assistance; Eckhart Kuijken, Christine Verscheure, Fred Cottaar and Per Ivar Nicolaisen for invaluable local knowledge of the goose stopover sites; and Silke Bauer for valuable comments on an earlier version of this manuscript. This study was supported through the Bird Health programme within the International Polar Year by the Netherlands Organisation for Scientific Research (NWO; grant 851.40.073 and 851.40.074), EU Framework six program NewFluBird (044490), contract NIAIDNIH HHSN266200700010C, JST PRESTO program, and the Danish Forest and Nature Agency. The Governor of Svalbard kindly gave permission to catch geese in Svalbard. This is publication 4875 of the Netherlands Institute of Ecology (NIOO-KNAW).

References

 

DC FieldValueLanguage
dc.contributor.authorHoye, BJen_HK
dc.contributor.authorMunster, VJen_HK
dc.contributor.authorNishiura, Hen_HK
dc.contributor.authorFouchier, RAMen_HK
dc.contributor.authorMadsen, Jen_HK
dc.contributor.authorKlaassen, Men_HK
dc.date.accessioned2011-06-13T07:20:41Z-
dc.date.available2011-06-13T07:20:41Z-
dc.date.issued2011en_HK
dc.identifier.citationOikos, 2011, v. 120 n. 5, p. 748-755en_HK
dc.identifier.issn0030-1299en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134179-
dc.description.abstractMigratory animals may play an important role in connecting disparate ecosystems, including the introduction of various pathogens. The incidence of these pathogens may vary over time and space, such that events along the entire migratory flyway are likely to be important in the interaction between pathogens and their migratory hosts. On this premise, the annual cycle of a naturally occurring host-pathogen system was reconstructed by examining infection with and antibodies to avian influenza virus along the flyway of a long-distance Arctic migrant, the Svalbard-breeding pink-footed goose Anser brachyrhynchus. A highly-localized transmission period was identified in winter, in contrast to the north-south decline expected from dabbling ducks, indicating the dynamics of infection may differ among host species. In spring, 63% (95% CI: 57.1, 68.9) of adults had detectable antibodies to the nucleoprotein of avian influenza virus, compared to just 15% (95% CI: 8.7, 23.4) of juveniles, suggesting inter-annual antibody maintenance. Nevertheless, adult seroprevalence declined by approximately 30% from spring to late summer, indicating significant seroreversion in the population. Integrating these findings in an epidemiological model, detectable antibodies to nucleoprotein were estimated to persist for just 343 days (95% CI: 221, 607); considerably shorter than for other wildlife diseases in long-lived bird species. The investigation of wildlife diseases in migratory populations is an inherently complex task, yet, by integrating disease incidence and seroprevalence along a migratory flyway, our findings suggest that the ecological interactions and life history of the host, as well as the life-history of the pathogen, can influence the dynamics of infection and host immune response. © 2011 The Authors.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ECOen_HK
dc.relation.ispartofOikosen_HK
dc.titleReconstructing an annual cycle of interaction: Natural infection and antibody dynamics to avian influenza along a migratory flywayen_HK
dc.typeArticleen_HK
dc.identifier.emailNishiura, H:nishiura@hku.hken_HK
dc.identifier.authorityNishiura, H=rp01488en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1600-0706.2010.18961.xen_HK
dc.identifier.scopuseid_2-s2.0-79955034772en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955034772&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume120en_HK
dc.identifier.issue5en_HK
dc.identifier.spage748en_HK
dc.identifier.epage755en_HK
dc.identifier.eissn1600-0706-
dc.identifier.isiWOS:000289740200012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHoye, BJ=26632061000en_HK
dc.identifier.scopusauthoridMunster, VJ=9332531900en_HK
dc.identifier.scopusauthoridNishiura, H=7005501836en_HK
dc.identifier.scopusauthoridFouchier, RAM=7006060466en_HK
dc.identifier.scopusauthoridMadsen, J=7201696125en_HK
dc.identifier.scopusauthoridKlaassen, M=7004383496en_HK
dc.identifier.citeulike9203824-

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