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Article: Household transmission of influenza (H1N1-2009) in Japan: Age-specificity and reduction of household transmission risk by Zanamivir treatment

TitleHousehold transmission of influenza (H1N1-2009) in Japan: Age-specificity and reduction of household transmission risk by Zanamivir treatment
Authors
KeywordsAntiviral Drugs
Epidemiology
H1n1-2009
Influenza
Neuraminidase Inhibitors
Oseltamivir
Pandemic
Prophylaxis
Zanamivir
Issue Date2011
PublisherCambridge Medical Publications. The Journal's web site is located at http://www.jimronline.net
Citation
Journal Of International Medical Research, 2011, v. 39 n. 2, p. 619-628 How to Cite?
AbstractThis study investigated household transmission data for influenza (H1N1-2009) in Japan in order to quantify the age-specific risk of infection and estimate the impact of antiviral treatment on the risk of household transmission. Among a total of 1547 households, involving 4609 household contacts, the secondary attack ratio (SAR) was estimated to be 11.4%. School children aged 5 - 18 years dominated the index cases. Age-specific infectiousness and susceptibility were highest among 0 - 4-year olds, with SAR estimated at 19.4% and 29.6%, respectively. Zanamivir treatment within 24 and 24 - 48 h of illness onset in index cases, respectively, reduced the risk of household transmission to 0.57 (95% CI 0.44, 0.73) and 0.58 (95% CI 0.38, 0.86) times that among those receiving the same treatment at > 48 h and those not receiving treatment. The preventive performance of antiviral treatment and prophylaxis should be further examined in randomized controlled trials. © 2011 Field House Publishing LLP.
Persistent Identifierhttp://hdl.handle.net/10722/134177
ISSN
2015 Impact Factor: 1.431
2015 SCImago Journal Rankings: 0.577
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNishiura, Hen_HK
dc.contributor.authorOshitani, Hen_HK
dc.date.accessioned2011-06-13T07:20:40Z-
dc.date.available2011-06-13T07:20:40Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of International Medical Research, 2011, v. 39 n. 2, p. 619-628en_HK
dc.identifier.issn0300-0605en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134177-
dc.description.abstractThis study investigated household transmission data for influenza (H1N1-2009) in Japan in order to quantify the age-specific risk of infection and estimate the impact of antiviral treatment on the risk of household transmission. Among a total of 1547 households, involving 4609 household contacts, the secondary attack ratio (SAR) was estimated to be 11.4%. School children aged 5 - 18 years dominated the index cases. Age-specific infectiousness and susceptibility were highest among 0 - 4-year olds, with SAR estimated at 19.4% and 29.6%, respectively. Zanamivir treatment within 24 and 24 - 48 h of illness onset in index cases, respectively, reduced the risk of household transmission to 0.57 (95% CI 0.44, 0.73) and 0.58 (95% CI 0.38, 0.86) times that among those receiving the same treatment at > 48 h and those not receiving treatment. The preventive performance of antiviral treatment and prophylaxis should be further examined in randomized controlled trials. © 2011 Field House Publishing LLP.en_HK
dc.languageengen_US
dc.publisherCambridge Medical Publications. The Journal's web site is located at http://www.jimronline.neten_HK
dc.relation.ispartofJournal of International Medical Researchen_HK
dc.subjectAntiviral Drugsen_US
dc.subjectEpidemiologyen_US
dc.subjectH1n1-2009en_US
dc.subjectInfluenzaen_US
dc.subjectNeuraminidase Inhibitorsen_US
dc.subjectOseltamiviren_US
dc.subjectPandemicen_US
dc.subjectProphylaxisen_US
dc.subjectZanamiviren_US
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAge Distributionen_HK
dc.subject.meshAntiviral Agents - pharmacology - therapeutic useen_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshFamily Characteristicsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfanten_HK
dc.subject.meshInfant, Newbornen_HK
dc.subject.meshInfluenza A Virus, H1N1 Subtype - drug effects - physiologyen_HK
dc.subject.meshInfluenza, Human - drug therapy - prevention & control - transmission - virologyen_HK
dc.subject.meshJapanen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMultivariate Analysisen_HK
dc.subject.meshOdds Ratioen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshYoung Adulten_HK
dc.subject.meshZanamivir - pharmacology - therapeutic useen_HK
dc.titleHousehold transmission of influenza (H1N1-2009) in Japan: Age-specificity and reduction of household transmission risk by Zanamivir treatmenten_HK
dc.typeArticleen_HK
dc.identifier.emailNishiura, H:nishiura@hku.hken_HK
dc.identifier.authorityNishiura, H=rp01488en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid21672367en_HK
dc.identifier.scopuseid_2-s2.0-79955673057en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955673057&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue2en_HK
dc.identifier.spage619en_HK
dc.identifier.epage628en_HK
dc.identifier.isiWOS:000291142200031-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridNishiura, H=7005501836en_HK
dc.identifier.scopusauthoridOshitani, H=35243518200en_HK

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