Article: Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation
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- Publisher Website: 10.1111/j.1365-2133.2010.10107.x
- Scopus: eid_2-s2.0-79952404701
- PMID: 21039409
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| Title | Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Yiu, KH2 Yeung, CK2 Chan, HT2 Wong, RMY2 Tam, S3 Lam, KF2 Yan, GH2 Yue, WS2 Chan, HH2 Tse, HF1 2 | ||||||
| Issue Date | 2011 | ||||||
| Publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJD | ||||||
| Citation | British Journal Of Dermatology, 2011, v. 164 n. 3, p. 514-520 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1365-2133.2010.10107.x | ||||||
| Abstract | Background Psoriasis is associated with premature atherosclerosis although the underlying mechanism remains unclear. Objectives We sought to investigate the relationship between disease activity and systemic inflammation in patients with psoriasis, and macrovascular and microvascular function. Methods Fifty-two patients with psoriasis (mean ± SD age 44 ± 8 years; 38 men) were compared with 50 age- and sex-matched controls. Baseline demographics and high-sensitivity C-reactive protein (hs-CRP) level were recorded for each subject. Psoriatic disease activity was assessed using the Psoriasis Area and Severity Index (PASI). Arterial stiffness and endothelial function were assessed using brachial to ankle pulse wave velocity (baPWV) and digital hyperaemic response measured using the peripheral arterial tonometry (PAT) index. Results Patients with psoriasis had significantly higher hs-CRP (mean ± SD 5·3 ± 5·1 vs. 1·9 ± 1·6 mg L -1, P < 0·01) and baPWV (mean ± SD 14·5 ± 2·5 vs. 13·2 ± 1·6 m s -1, P < 0·01) but not PAT index (mean ± SD 2·06 ± 0·59 vs. 2·10 ± 0·44, P = 0·70) than controls. There was significant correlation of hs-CRP with baPWV (r = 0·51, P < 0·01) and with PASI (r = 0·48, P < 0·01). Multiple linear regression analysis demonstrated that baPWV is independently correlated with age, fasting glucose and hs-CRP (P < 0·05), but does not predict PAT index. Each mg L -1 increase in hs-CRP accounted for an increase in baPWV of +0·12 m s -1 (95% confidence interval 0·01-0·22, P = 0·03). Conclusions Young patients with psoriasis have increased arterial stiffness but not microvascular dysfunction compared with healthy controls. More importantly, hs-CRP positively correlated with, and independently predicted, arterial stiffness. This suggests that systemic inflammation in patients with psoriasis is associated with premature atherosclerosis. © 2011 The Authors. BJD © 2011 British Association of Dermatologists. | ||||||
| ISSN | 0007-0963 2011 Impact Factor: 3.666 2011 SCImago Journal Rankings: 0.342 | ||||||
| DOI | http://dx.doi.org/10.1111/j.1365-2133.2010.10107.x | ||||||
| ISI Accession Number ID | WOS:000288076200011
Funding Information: This study was supported by the CRCG Small Project Funding of University of Hong Kong (Project No. 200907176060) and Sun Chieh Yeh Heart Foundation. | ||||||
| References | References in Scopus | ||||||
| Grants | Clinical evaluation of single versus multiple visit endodontic therapy |
| dc.contributor.author | Yiu, KH | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Yeung, CK | ||||||
| dc.contributor.author | Chan, HT | ||||||
| dc.contributor.author | Wong, RMY | ||||||
| dc.contributor.author | Tam, S | ||||||
| dc.contributor.author | Lam, KF | ||||||
| dc.contributor.author | Yan, GH | ||||||
| dc.contributor.author | Yue, WS | ||||||
| dc.contributor.author | Chan, HH | ||||||
| dc.contributor.author | Tse, HF | ||||||
| dc.date.accessioned | 2011-06-13T07:20:23Z | ||||||
| dc.date.available | 2011-06-13T07:20:23Z | ||||||
| dc.date.issued | 2011 | ||||||
| dc.description.abstract | Background Psoriasis is associated with premature atherosclerosis although the underlying mechanism remains unclear. Objectives We sought to investigate the relationship between disease activity and systemic inflammation in patients with psoriasis, and macrovascular and microvascular function. Methods Fifty-two patients with psoriasis (mean ± SD age 44 ± 8 years; 38 men) were compared with 50 age- and sex-matched controls. Baseline demographics and high-sensitivity C-reactive protein (hs-CRP) level were recorded for each subject. Psoriatic disease activity was assessed using the Psoriasis Area and Severity Index (PASI). Arterial stiffness and endothelial function were assessed using brachial to ankle pulse wave velocity (baPWV) and digital hyperaemic response measured using the peripheral arterial tonometry (PAT) index. Results Patients with psoriasis had significantly higher hs-CRP (mean ± SD 5·3 ± 5·1 vs. 1·9 ± 1·6 mg L -1, P < 0·01) and baPWV (mean ± SD 14·5 ± 2·5 vs. 13·2 ± 1·6 m s -1, P < 0·01) but not PAT index (mean ± SD 2·06 ± 0·59 vs. 2·10 ± 0·44, P = 0·70) than controls. There was significant correlation of hs-CRP with baPWV (r = 0·51, P < 0·01) and with PASI (r = 0·48, P < 0·01). Multiple linear regression analysis demonstrated that baPWV is independently correlated with age, fasting glucose and hs-CRP (P < 0·05), but does not predict PAT index. Each mg L -1 increase in hs-CRP accounted for an increase in baPWV of +0·12 m s -1 (95% confidence interval 0·01-0·22, P = 0·03). Conclusions Young patients with psoriasis have increased arterial stiffness but not microvascular dysfunction compared with healthy controls. More importantly, hs-CRP positively correlated with, and independently predicted, arterial stiffness. This suggests that systemic inflammation in patients with psoriasis is associated with premature atherosclerosis. © 2011 The Authors. BJD © 2011 British Association of Dermatologists. | ||||||
| dc.description.grant | Clinical evaluation of single versus multiple visit endodontic therapy | ||||||
| dc.description.grantcode | 101321 | ||||||
| dc.description.nature | link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | British Journal Of Dermatology, 2011, v. 164 n. 3, p. 514-520 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1365-2133.2010.10107.x | ||||||
| dc.identifier.citeulike | 8975159 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1111/j.1365-2133.2010.10107.x | ||||||
| dc.identifier.epage | 520 | ||||||
| dc.identifier.hkuros | 187069 | ||||||
| dc.identifier.hkuros | 201281 | ||||||
| dc.identifier.isi | WOS:000288076200011
Funding Information: This study was supported by the CRCG Small Project Funding of University of Hong Kong (Project No. 200907176060) and Sun Chieh Yeh Heart Foundation. | ||||||
| dc.identifier.issn | 0007-0963 2011 Impact Factor: 3.666 2011 SCImago Journal Rankings: 0.342 | ||||||
| dc.identifier.issue | 3 | ||||||
| dc.identifier.openurl | | ||||||
| dc.identifier.pmid | 21039409 | ||||||
| dc.identifier.scopus | eid_2-s2.0-79952404701 | ||||||
| dc.identifier.spage | 514 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/134159 | ||||||
| dc.identifier.volume | 164 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJD | ||||||
| dc.publisher.place | United Kingdom | ||||||
| dc.relation.ispartof | British Journal of Dermatology | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.rights | The definitive version is available at www.blackwell-synergy.com | ||||||
| dc.subject.mesh | Arteries - physiopathology | ||||||
| dc.subject.mesh | Atherosclerosis - etiology - physiopathology | ||||||
| dc.subject.mesh | Biological Markers - blood | ||||||
| dc.subject.mesh | Psoriasis - complications - physiopathology | ||||||
| dc.subject.mesh | Vascular Resistance | ||||||
| dc.title | Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong Li Ka Shing Faculty of Medicine
- The University of Hong Kong
- Queen Mary Hospital Hong Kong