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Article: Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation

TitleIncreased arterial stiffness in patients with psoriasis is associated with active systemic inflammation
Authors
Issue Date2011
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJD
Citation
British Journal Of Dermatology, 2011, v. 164 n. 3, p. 514-520 How to Cite?
Abstract
Background Psoriasis is associated with premature atherosclerosis although the underlying mechanism remains unclear. Objectives We sought to investigate the relationship between disease activity and systemic inflammation in patients with psoriasis, and macrovascular and microvascular function. Methods Fifty-two patients with psoriasis (mean ± SD age 44 ± 8 years; 38 men) were compared with 50 age- and sex-matched controls. Baseline demographics and high-sensitivity C-reactive protein (hs-CRP) level were recorded for each subject. Psoriatic disease activity was assessed using the Psoriasis Area and Severity Index (PASI). Arterial stiffness and endothelial function were assessed using brachial to ankle pulse wave velocity (baPWV) and digital hyperaemic response measured using the peripheral arterial tonometry (PAT) index. Results Patients with psoriasis had significantly higher hs-CRP (mean ± SD 5·3 ± 5·1 vs. 1·9 ± 1·6 mg L -1, P < 0·01) and baPWV (mean ± SD 14·5 ± 2·5 vs. 13·2 ± 1·6 m s -1, P < 0·01) but not PAT index (mean ± SD 2·06 ± 0·59 vs. 2·10 ± 0·44, P = 0·70) than controls. There was significant correlation of hs-CRP with baPWV (r = 0·51, P < 0·01) and with PASI (r = 0·48, P < 0·01). Multiple linear regression analysis demonstrated that baPWV is independently correlated with age, fasting glucose and hs-CRP (P < 0·05), but does not predict PAT index. Each mg L -1 increase in hs-CRP accounted for an increase in baPWV of +0·12 m s -1 (95% confidence interval 0·01-0·22, P = 0·03). Conclusions Young patients with psoriasis have increased arterial stiffness but not microvascular dysfunction compared with healthy controls. More importantly, hs-CRP positively correlated with, and independently predicted, arterial stiffness. This suggests that systemic inflammation in patients with psoriasis is associated with premature atherosclerosis. © 2011 The Authors. BJD © 2011 British Association of Dermatologists.
Persistent Identifierhttp://hdl.handle.net/10722/134159
ISSN
2013 Impact Factor: 4.100
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong200907176060
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was supported by the CRCG Small Project Funding of University of Hong Kong (Project No. 200907176060) and Sun Chieh Yeh Heart Foundation.

References

 

Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Queen Mary Hospital Hong Kong
DC FieldValueLanguage
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorYeung, CKen_HK
dc.contributor.authorChan, HTen_HK
dc.contributor.authorWong, RMYen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorLam, KFen_HK
dc.contributor.authorYan, GHen_HK
dc.contributor.authorYue, WSen_HK
dc.contributor.authorChan, HHen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2011-06-13T07:20:23Z-
dc.date.available2011-06-13T07:20:23Z-
dc.date.issued2011en_HK
dc.identifier.citationBritish Journal Of Dermatology, 2011, v. 164 n. 3, p. 514-520en_HK
dc.identifier.issn0007-0963en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134159-
dc.description.abstractBackground Psoriasis is associated with premature atherosclerosis although the underlying mechanism remains unclear. Objectives We sought to investigate the relationship between disease activity and systemic inflammation in patients with psoriasis, and macrovascular and microvascular function. Methods Fifty-two patients with psoriasis (mean ± SD age 44 ± 8 years; 38 men) were compared with 50 age- and sex-matched controls. Baseline demographics and high-sensitivity C-reactive protein (hs-CRP) level were recorded for each subject. Psoriatic disease activity was assessed using the Psoriasis Area and Severity Index (PASI). Arterial stiffness and endothelial function were assessed using brachial to ankle pulse wave velocity (baPWV) and digital hyperaemic response measured using the peripheral arterial tonometry (PAT) index. Results Patients with psoriasis had significantly higher hs-CRP (mean ± SD 5·3 ± 5·1 vs. 1·9 ± 1·6 mg L -1, P < 0·01) and baPWV (mean ± SD 14·5 ± 2·5 vs. 13·2 ± 1·6 m s -1, P < 0·01) but not PAT index (mean ± SD 2·06 ± 0·59 vs. 2·10 ± 0·44, P = 0·70) than controls. There was significant correlation of hs-CRP with baPWV (r = 0·51, P < 0·01) and with PASI (r = 0·48, P < 0·01). Multiple linear regression analysis demonstrated that baPWV is independently correlated with age, fasting glucose and hs-CRP (P < 0·05), but does not predict PAT index. Each mg L -1 increase in hs-CRP accounted for an increase in baPWV of +0·12 m s -1 (95% confidence interval 0·01-0·22, P = 0·03). Conclusions Young patients with psoriasis have increased arterial stiffness but not microvascular dysfunction compared with healthy controls. More importantly, hs-CRP positively correlated with, and independently predicted, arterial stiffness. This suggests that systemic inflammation in patients with psoriasis is associated with premature atherosclerosis. © 2011 The Authors. BJD © 2011 British Association of Dermatologists.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJDen_HK
dc.relation.ispartofBritish Journal of Dermatologyen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subject.meshArteries - physiopathology-
dc.subject.meshAtherosclerosis - etiology - physiopathology-
dc.subject.meshBiological Markers - blood-
dc.subject.meshPsoriasis - complications - physiopathology-
dc.subject.meshVascular Resistance-
dc.titleIncreased arterial stiffness in patients with psoriasis is associated with active systemic inflammationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-0963&volume=164&issue=3&spage=514&epage=520&date=2011&atitle=Increased+arterial+stiffness+in+patients+with+psoriasis+is+associated+with+active+systemic+inflammation-
dc.identifier.emailYiu, KH:khkyiu@hku.hken_HK
dc.identifier.emailLam, KF:hrntlkf@hkucc.hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authorityLam, KF=rp00718en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2133.2010.10107.xen_HK
dc.identifier.pmid21039409en_HK
dc.identifier.scopuseid_2-s2.0-79952404701en_HK
dc.identifier.hkuros187069-
dc.identifier.hkuros201281-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952404701&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume164en_HK
dc.identifier.issue3en_HK
dc.identifier.spage514en_HK
dc.identifier.epage520en_HK
dc.identifier.eissn1365-2133-
dc.identifier.isiWOS:000288076200011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridYeung, CK=7201354123en_HK
dc.identifier.scopusauthoridChan, HT=22633582100en_HK
dc.identifier.scopusauthoridWong, RMY=38663775700en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridLam, KF=8948421200en_HK
dc.identifier.scopusauthoridYan, GH=36544693600en_HK
dc.identifier.scopusauthoridYue, WS=36106565300en_HK
dc.identifier.scopusauthoridChan, HH=24555248900en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.citeulike8975159-

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