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Article: Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation
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TitleIncreased arterial stiffness in patients with psoriasis is associated with active systemic inflammation
 
AuthorsYiu, KH2
Yeung, CK2
Chan, HT2
Wong, RMY2
Tam, S3
Lam, KF2
Yan, GH2
Yue, WS2
Chan, HH2
Tse, HF2 1
 
Issue Date2011
 
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJD
 
CitationBritish Journal Of Dermatology, 2011, v. 164 n. 3, p. 514-520 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2133.2010.10107.x
 
AbstractBackground Psoriasis is associated with premature atherosclerosis although the underlying mechanism remains unclear. Objectives We sought to investigate the relationship between disease activity and systemic inflammation in patients with psoriasis, and macrovascular and microvascular function. Methods Fifty-two patients with psoriasis (mean ± SD age 44 ± 8 years; 38 men) were compared with 50 age- and sex-matched controls. Baseline demographics and high-sensitivity C-reactive protein (hs-CRP) level were recorded for each subject. Psoriatic disease activity was assessed using the Psoriasis Area and Severity Index (PASI). Arterial stiffness and endothelial function were assessed using brachial to ankle pulse wave velocity (baPWV) and digital hyperaemic response measured using the peripheral arterial tonometry (PAT) index. Results Patients with psoriasis had significantly higher hs-CRP (mean ± SD 5·3 ± 5·1 vs. 1·9 ± 1·6 mg L -1, P < 0·01) and baPWV (mean ± SD 14·5 ± 2·5 vs. 13·2 ± 1·6 m s -1, P < 0·01) but not PAT index (mean ± SD 2·06 ± 0·59 vs. 2·10 ± 0·44, P = 0·70) than controls. There was significant correlation of hs-CRP with baPWV (r = 0·51, P < 0·01) and with PASI (r = 0·48, P < 0·01). Multiple linear regression analysis demonstrated that baPWV is independently correlated with age, fasting glucose and hs-CRP (P < 0·05), but does not predict PAT index. Each mg L -1 increase in hs-CRP accounted for an increase in baPWV of +0·12 m s -1 (95% confidence interval 0·01-0·22, P = 0·03). Conclusions Young patients with psoriasis have increased arterial stiffness but not microvascular dysfunction compared with healthy controls. More importantly, hs-CRP positively correlated with, and independently predicted, arterial stiffness. This suggests that systemic inflammation in patients with psoriasis is associated with premature atherosclerosis. © 2011 The Authors. BJD © 2011 British Association of Dermatologists.
 
ISSN0007-0963
2013 Impact Factor: 4.100
 
DOIhttp://dx.doi.org/10.1111/j.1365-2133.2010.10107.x
 
ISI Accession Number IDWOS:000288076200011
Funding AgencyGrant Number
University of Hong Kong200907176060
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was supported by the CRCG Small Project Funding of University of Hong Kong (Project No. 200907176060) and Sun Chieh Yeh Heart Foundation.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYiu, KH
 
dc.contributor.authorYeung, CK
 
dc.contributor.authorChan, HT
 
dc.contributor.authorWong, RMY
 
dc.contributor.authorTam, S
 
dc.contributor.authorLam, KF
 
dc.contributor.authorYan, GH
 
dc.contributor.authorYue, WS
 
dc.contributor.authorChan, HH
 
dc.contributor.authorTse, HF
 
dc.date.accessioned2011-06-13T07:20:23Z
 
dc.date.available2011-06-13T07:20:23Z
 
dc.date.issued2011
 
dc.description.abstractBackground Psoriasis is associated with premature atherosclerosis although the underlying mechanism remains unclear. Objectives We sought to investigate the relationship between disease activity and systemic inflammation in patients with psoriasis, and macrovascular and microvascular function. Methods Fifty-two patients with psoriasis (mean ± SD age 44 ± 8 years; 38 men) were compared with 50 age- and sex-matched controls. Baseline demographics and high-sensitivity C-reactive protein (hs-CRP) level were recorded for each subject. Psoriatic disease activity was assessed using the Psoriasis Area and Severity Index (PASI). Arterial stiffness and endothelial function were assessed using brachial to ankle pulse wave velocity (baPWV) and digital hyperaemic response measured using the peripheral arterial tonometry (PAT) index. Results Patients with psoriasis had significantly higher hs-CRP (mean ± SD 5·3 ± 5·1 vs. 1·9 ± 1·6 mg L -1, P < 0·01) and baPWV (mean ± SD 14·5 ± 2·5 vs. 13·2 ± 1·6 m s -1, P < 0·01) but not PAT index (mean ± SD 2·06 ± 0·59 vs. 2·10 ± 0·44, P = 0·70) than controls. There was significant correlation of hs-CRP with baPWV (r = 0·51, P < 0·01) and with PASI (r = 0·48, P < 0·01). Multiple linear regression analysis demonstrated that baPWV is independently correlated with age, fasting glucose and hs-CRP (P < 0·05), but does not predict PAT index. Each mg L -1 increase in hs-CRP accounted for an increase in baPWV of +0·12 m s -1 (95% confidence interval 0·01-0·22, P = 0·03). Conclusions Young patients with psoriasis have increased arterial stiffness but not microvascular dysfunction compared with healthy controls. More importantly, hs-CRP positively correlated with, and independently predicted, arterial stiffness. This suggests that systemic inflammation in patients with psoriasis is associated with premature atherosclerosis. © 2011 The Authors. BJD © 2011 British Association of Dermatologists.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationBritish Journal Of Dermatology, 2011, v. 164 n. 3, p. 514-520 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2133.2010.10107.x
 
dc.identifier.citeulike8975159
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1365-2133.2010.10107.x
 
dc.identifier.eissn1365-2133
 
dc.identifier.epage520
 
dc.identifier.hkuros187069
 
dc.identifier.hkuros201281
 
dc.identifier.isiWOS:000288076200011
Funding AgencyGrant Number
University of Hong Kong200907176060
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was supported by the CRCG Small Project Funding of University of Hong Kong (Project No. 200907176060) and Sun Chieh Yeh Heart Foundation.

 
dc.identifier.issn0007-0963
2013 Impact Factor: 4.100
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.pmid21039409
 
dc.identifier.scopuseid_2-s2.0-79952404701
 
dc.identifier.spage514
 
dc.identifier.urihttp://hdl.handle.net/10722/134159
 
dc.identifier.volume164
 
dc.languageeng
 
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJD
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofBritish Journal of Dermatology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe definitive version is available at www.blackwell-synergy.com
 
dc.subject.meshArteries - physiopathology
 
dc.subject.meshAtherosclerosis - etiology - physiopathology
 
dc.subject.meshBiological Markers - blood
 
dc.subject.meshPsoriasis - complications - physiopathology
 
dc.subject.meshVascular Resistance
 
dc.titleIncreased arterial stiffness in patients with psoriasis is associated with active systemic inflammation
 
dc.typeArticle
 
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<contributor.author>Yeung, CK</contributor.author>
<contributor.author>Chan, HT</contributor.author>
<contributor.author>Wong, RMY</contributor.author>
<contributor.author>Tam, S</contributor.author>
<contributor.author>Lam, KF</contributor.author>
<contributor.author>Yan, GH</contributor.author>
<contributor.author>Yue, WS</contributor.author>
<contributor.author>Chan, HH</contributor.author>
<contributor.author>Tse, HF</contributor.author>
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<description.abstract>Background Psoriasis is associated with premature atherosclerosis although the underlying mechanism remains unclear. Objectives We sought to investigate the relationship between disease activity and systemic inflammation in patients with psoriasis, and macrovascular and microvascular function. Methods Fifty-two patients with psoriasis (mean &#177; SD age 44 &#177; 8 years; 38 men) were compared with 50 age- and sex-matched controls. Baseline demographics and high-sensitivity C-reactive protein (hs-CRP) level were recorded for each subject. Psoriatic disease activity was assessed using the Psoriasis Area and Severity Index (PASI). Arterial stiffness and endothelial function were assessed using brachial to ankle pulse wave velocity (baPWV) and digital hyperaemic response measured using the peripheral arterial tonometry (PAT) index. Results Patients with psoriasis had significantly higher hs-CRP (mean &#177; SD 5&#183;3 &#177; 5&#183;1 vs. 1&#183;9 &#177; 1&#183;6 mg L -1, P &lt; 0&#183;01) and baPWV (mean &#177; SD 14&#183;5 &#177; 2&#183;5 vs. 13&#183;2 &#177; 1&#183;6 m s -1, P &lt; 0&#183;01) but not PAT index (mean &#177; SD 2&#183;06 &#177; 0&#183;59 vs. 2&#183;10 &#177; 0&#183;44, P = 0&#183;70) than controls. There was significant correlation of hs-CRP with baPWV (r = 0&#183;51, P &lt; 0&#183;01) and with PASI (r = 0&#183;48, P &lt; 0&#183;01). Multiple linear regression analysis demonstrated that baPWV is independently correlated with age, fasting glucose and hs-CRP (P &lt; 0&#183;05), but does not predict PAT index. Each mg L -1 increase in hs-CRP accounted for an increase in baPWV of +0&#183;12 m s -1 (95% confidence interval 0&#183;01-0&#183;22, P = 0&#183;03). Conclusions Young patients with psoriasis have increased arterial stiffness but not microvascular dysfunction compared with healthy controls. More importantly, hs-CRP positively correlated with, and independently predicted, arterial stiffness. This suggests that systemic inflammation in patients with psoriasis is associated with premature atherosclerosis. &#169; 2011 The Authors. BJD &#169; 2011 British Association of Dermatologists.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Queen Mary Hospital Hong Kong