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Article: Virtual histology by intravascular ultrasound study on degenerative aortocoronary saphenous vein grafts

TitleVirtual histology by intravascular ultrasound study on degenerative aortocoronary saphenous vein grafts
Authors
Issue Date2010
PublisherSpringer Japan. The Journal's web site is located at www.springerlink.com/openurl.asp?genre=journal&issn=0910-8327
Citation
Heart And Vessels, 2010, v. 25 n. 3, p. 175-181 How to Cite?
AbstractData of virtual histology (VH) acquired by intravascular ultrasound (IVUS) on saphenous vein graft (SVG) lesions is lacking. This study sought to report the VH IVUS findings in degenerative aortocoronary SVG lesions and correlate various types of plaque compositions (fibrous, fibro-fatty, dense calcium, and necrotic core) with different clinical and lesion characteristics. Virtual histology IVUS was performed on SVG in 38 symptomatic patients with a history of coronary artery bypass grafting, who underwent percutaneous coronary intervention on either native vessels or SVG. Measurements were made at the image slice with the smallest lumen. A total of 54 SVG lesions were analyzed; the mean graft age was 13.7 ± 4.0 years. The mean vessel size was 5.0 ± 1.0 mm; plaque area was 13.4 ± 7.3 mm2, and plaque burden was 63.0% ± 15.0%. Fibrous tissue represented the major plaque component (62.1% ± 17.1%). Lesions with a plaque burden of ≥70% were associated with positive remodeling, larger vessel size, higher percentage of fibro-fatty tissue, but lower percentage of dense calcium. Plaque burden was found to be positively correlated with remodeling index (r = 0.37, P = 0.01) and % fibro-fatty tissue (r = 0.49, P < 0.001) but negatively correlated with % dense calcium (r =-0.31, P = 0.03). The severity of SVG atherosclerosis paralleled with a proportional increase in fibro-fatty tissue. Unstable plaques in SVG were associated with positive remodeling, lipid-rich atheroma, and less calcium deposition, similar to the VH IVUS findings in native coronary arteries. © Springer 2010.
Persistent Identifierhttp://hdl.handle.net/10722/134134
ISSN
2015 Impact Factor: 2.293
2015 SCImago Journal Rankings: 0.709
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJim, MHen_HK
dc.contributor.authorHau, WKTen_HK
dc.contributor.authorKo, RLYen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorHo, HHen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorChow, WHen_HK
dc.date.accessioned2011-06-13T07:20:00Z-
dc.date.available2011-06-13T07:20:00Z-
dc.date.issued2010en_HK
dc.identifier.citationHeart And Vessels, 2010, v. 25 n. 3, p. 175-181en_HK
dc.identifier.issn0910-8327en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134134-
dc.description.abstractData of virtual histology (VH) acquired by intravascular ultrasound (IVUS) on saphenous vein graft (SVG) lesions is lacking. This study sought to report the VH IVUS findings in degenerative aortocoronary SVG lesions and correlate various types of plaque compositions (fibrous, fibro-fatty, dense calcium, and necrotic core) with different clinical and lesion characteristics. Virtual histology IVUS was performed on SVG in 38 symptomatic patients with a history of coronary artery bypass grafting, who underwent percutaneous coronary intervention on either native vessels or SVG. Measurements were made at the image slice with the smallest lumen. A total of 54 SVG lesions were analyzed; the mean graft age was 13.7 ± 4.0 years. The mean vessel size was 5.0 ± 1.0 mm; plaque area was 13.4 ± 7.3 mm2, and plaque burden was 63.0% ± 15.0%. Fibrous tissue represented the major plaque component (62.1% ± 17.1%). Lesions with a plaque burden of ≥70% were associated with positive remodeling, larger vessel size, higher percentage of fibro-fatty tissue, but lower percentage of dense calcium. Plaque burden was found to be positively correlated with remodeling index (r = 0.37, P = 0.01) and % fibro-fatty tissue (r = 0.49, P < 0.001) but negatively correlated with % dense calcium (r =-0.31, P = 0.03). The severity of SVG atherosclerosis paralleled with a proportional increase in fibro-fatty tissue. Unstable plaques in SVG were associated with positive remodeling, lipid-rich atheroma, and less calcium deposition, similar to the VH IVUS findings in native coronary arteries. © Springer 2010.en_HK
dc.languageengen_US
dc.publisherSpringer Japan. The Journal's web site is located at www.springerlink.com/openurl.asp?genre=journal&issn=0910-8327en_HK
dc.relation.ispartofHeart and Vesselsen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAngioplasty, Balloon, Coronaryen_HK
dc.subject.meshAtherosclerosis - etiology - metabolism - therapy - ultrasonographyen_HK
dc.subject.meshCalcium - analysisen_HK
dc.subject.meshChi-Square Distributionen_HK
dc.subject.meshCoronary Artery Bypass - adverse effectsen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFibrosisen_HK
dc.subject.meshGraft Occlusion, Vascular - etiology - metabolism - therapy - ultrasonographyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLinear Modelsen_HK
dc.subject.meshLipids - analysisen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNecrosisen_HK
dc.subject.meshPredictive Value of Testsen_HK
dc.subject.meshRisk Assessmenten_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSaphenous Vein - chemistry - transplantation - ultrasonographyen_HK
dc.subject.meshSeverity of Illness Indexen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.subject.meshUltrasonography, Interventionalen_HK
dc.titleVirtual histology by intravascular ultrasound study on degenerative aortocoronary saphenous vein graftsen_HK
dc.typeArticleen_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailYiu, KH:khkyiu@hku.hken_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00380-009-1185-7en_HK
dc.identifier.pmid20512443-
dc.identifier.scopuseid_2-s2.0-77956142188en_HK
dc.identifier.hkuros158988-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77956142188&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue3en_HK
dc.identifier.spage175en_HK
dc.identifier.epage181en_HK
dc.identifier.isiWOS:000278153500001-
dc.publisher.placeJapanen_HK
dc.identifier.scopusauthoridJim, MH=6603860344en_HK
dc.identifier.scopusauthoridHau, WKT=36499586100en_HK
dc.identifier.scopusauthoridKo, RLY=15020468300en_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridHo, HH=7401465369en_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridLau, CP=35275317200en_HK
dc.identifier.scopusauthoridChow, WH=7402281062en_HK
dc.identifier.citeulike7374364-

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