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Article: Long-term clinical outcomes of drug-eluting stents vs bare-metal stents in Chinese patients

TitleLong-term clinical outcomes of drug-eluting stents vs bare-metal stents in Chinese patients
Authors
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.clinicalcardiology.org
Citation
Clinical Cardiology, 2010, v. 33 n. 6, p. E22-E29 How to Cite?
AbstractBackground: There is limited data on the magnitude of the problem of drug-eluting stent (DES) thrombosis in the Asian population. Hypothesis: We evaluated the long-term clinical outcomes of DES vs bare metal stents (BMS) in Chinese patients. Methods: From January 2002 to October 2005, 1236 consecutive patients underwent percutaneous coronary intervention with DES or BMS coronary stent implantation at our institution. We analyzed major clinical end points like all-cause mortality, cardiovascular death, myocardial infarction, target lesion revascularization (TLR), and stent thrombosis. Results: The 3-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction were significantly lower in the DES group (3.4%, 0.9%, 3.6%) when compared with the BMS group (7.5%, 4.4%, 6.2%; P < .05). No significant differences were found in the 3-year cumulative rates for TLR or stent thrombosis when comparing the DES group (8.3%, 1.63%) vs the BMS group (9.6%, 1.6%; P > .05). However, after 1 year, there were 8 episodes of stent thrombosis in the DES group vs 1 episode of stent thrombosis in the BMS group (P = .04). Conclusion: Drug-eluting stents are associated with a significant reduction in the 3-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction when compared to BMS. However, there were no significant differences in the cumulative rates of TLR or stent thrombosis at 3 years. Stent thrombosis after 1 year was more common in the DES group, but this did not translate to increased mortality. The suggestion that DES might confer amortality benefit should be interpreted with caution as there could be several confounding factors that were not identified in our study. © 2010 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/134131
ISSN
2015 Impact Factor: 2.431
2015 SCImago Journal Rankings: 1.309
References

 

DC FieldValueLanguage
dc.contributor.authorHo, HHen_HK
dc.contributor.authorPong, Ven_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorJim, MHen_HK
dc.contributor.authorMiu, Ren_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorKo, Ren_HK
dc.contributor.authorTse, HFen_HK
dc.contributor.authorKwok, OHen_HK
dc.contributor.authorChow, WHen_HK
dc.date.accessioned2011-06-13T07:19:57Z-
dc.date.available2011-06-13T07:19:57Z-
dc.date.issued2010en_HK
dc.identifier.citationClinical Cardiology, 2010, v. 33 n. 6, p. E22-E29en_HK
dc.identifier.issn0160-9289en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134131-
dc.description.abstractBackground: There is limited data on the magnitude of the problem of drug-eluting stent (DES) thrombosis in the Asian population. Hypothesis: We evaluated the long-term clinical outcomes of DES vs bare metal stents (BMS) in Chinese patients. Methods: From January 2002 to October 2005, 1236 consecutive patients underwent percutaneous coronary intervention with DES or BMS coronary stent implantation at our institution. We analyzed major clinical end points like all-cause mortality, cardiovascular death, myocardial infarction, target lesion revascularization (TLR), and stent thrombosis. Results: The 3-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction were significantly lower in the DES group (3.4%, 0.9%, 3.6%) when compared with the BMS group (7.5%, 4.4%, 6.2%; P < .05). No significant differences were found in the 3-year cumulative rates for TLR or stent thrombosis when comparing the DES group (8.3%, 1.63%) vs the BMS group (9.6%, 1.6%; P > .05). However, after 1 year, there were 8 episodes of stent thrombosis in the DES group vs 1 episode of stent thrombosis in the BMS group (P = .04). Conclusion: Drug-eluting stents are associated with a significant reduction in the 3-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction when compared to BMS. However, there were no significant differences in the cumulative rates of TLR or stent thrombosis at 3 years. Stent thrombosis after 1 year was more common in the DES group, but this did not translate to increased mortality. The suggestion that DES might confer amortality benefit should be interpreted with caution as there could be several confounding factors that were not identified in our study. © 2010 Wiley Periodicals, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.clinicalcardiology.orgen_HK
dc.relation.ispartofClinical Cardiologyen_HK
dc.subject.meshAngioplasty, Balloon, Coronary - adverse effects - instrumentation - mortality-
dc.subject.meshAsian Continental Ancestry Group - statistics and numerical data-
dc.subject.meshCoronary Artery Disease - ethnology - mortality - radiography - therapy-
dc.subject.meshDrug-Eluting Stents-
dc.subject.meshMetals-
dc.titleLong-term clinical outcomes of drug-eluting stents vs bare-metal stents in Chinese patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0160-9289&volume=&spage=&epage=&date=2009&atitle=Long-term+outcomes+of+drug-eluting+stents+versus+bare-metal+stents+in+Chinese.+en_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailYiu, KH:khkyiu@hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/clc.20655en_HK
dc.identifier.pmid20556818-
dc.identifier.scopuseid_2-s2.0-77953836397en_HK
dc.identifier.hkuros187300-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953836397&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue6en_HK
dc.identifier.spageE22en_HK
dc.identifier.epageE29en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHo, HH=7401465369en_HK
dc.identifier.scopusauthoridPong, V=26025247300en_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridJim, MH=6603860344en_HK
dc.identifier.scopusauthoridMiu, R=7801613455en_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridKo, R=15020468300en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridKwok, OH=7004955826en_HK
dc.identifier.scopusauthoridChow, WH=7402281062en_HK

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