File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Elevated pulmonary artery systolic pressure in patients with coronary artery disease and left ventricular dyssynchrony

TitleElevated pulmonary artery systolic pressure in patients with coronary artery disease and left ventricular dyssynchrony
Authors
KeywordsCoronary artery disease
Pulmonary artery systolic pressure
Ventricular dyssynchrony
Issue Date2010
PublisherOxford University Press. The Journal's web site is located at http://eurjhf.oxfordjournals.org
Citation
European Journal Of Heart Failure, 2010, v. 12 n. 10, p. 1067-1075 How to Cite?
AbstractAimsWe sought to determine whether inter-or intra-ventricular systolic dyssynchrony contributes to the occurrence of elevated pulmonary artery systolic pressure (PASP) in patients with coronary artery disease (CAD).Methods and resultsOne hundred and fifty-three consecutive CAD patients with preserved left ventricular ejection fraction (LVEF >40) were enrolled. Detailed echocardiography was performed to measure PASP, inter-ventricular dyssynchrony (Ts-RL: time difference between lateral and right free wall), and intra-ventricular dyssynchrony (Ts-SD, standard deviation of time to peak systolic velocity of 12 LV segments; Ts-12, maximal difference in Ts between any 2 of 12 LV segments; Ts-6-basal, maximal difference in Ts between any 2 of 6 basal LV segments). Elevated PASP (>35 mmHg) was confirmed in 46 patients who had significantly prolonged intra-ventricular dyssynchrony (Ts-SD: 49.9 ± 19.6 vs.37.9 ± 19.8 ms; Ts-12: 147.9 ± 56.4 vs.110.9 ± 53.9 ms; Ts-6-basal: 114.2 ± 51.9 vs. 85.7 ± 48.5 ms, all P < 0.01) and inter-ventricular dyssynchrony (Ts-RL: 78.7 ± 46.4 vs. 62.7 ± 34.3 ms, P = 0.019) compared with those without elevated PASP. Indexes of intra-and inter-ventricular dyssynchrony and LV filling pressure (E/e′) were significantly correlated with PASP. Multivariate analysis showed that left atrial dimension [odds ratio (OR) 4.23, 95 confidence interval (CI) 1.64-10.90], E/e′ septal (OR 1.15, 95 CI 1.04-1.27), pulmonary vascular resistance (OR 5.38, 95 CI 1.55-18.74), and Ts-RL (OR 1.02, 95 CI 1.01-1.03) were independent predictors for the occurrence of elevated PASP (all P < 0.05).ConclusionElevated PASP is common in CAD patients with preserved LVEF and is associated with LV diastolic dysfunction and LV mechanical dyssynchrony. © 2010 The Author.
Persistent Identifierhttp://hdl.handle.net/10722/134127
ISSN
2015 Impact Factor: 5.135
2015 SCImago Journal Rankings: 3.638
ISI Accession Number ID
Funding AgencyGrant Number
Research Grant Council of Hong KongHKU 7777/07M
HKU 7775/08M
Funding Information:

This study was supported by General Research Fund of Research Grant Council of Hong Kong (HKU 7777/07M and HKU 7775/08M).

References

 

DC FieldValueLanguage
dc.contributor.authorYan, GHen_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorYue, WSen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorLee, SWLen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2011-06-13T07:19:54Z-
dc.date.available2011-06-13T07:19:54Z-
dc.date.issued2010en_HK
dc.identifier.citationEuropean Journal Of Heart Failure, 2010, v. 12 n. 10, p. 1067-1075en_HK
dc.identifier.issn1388-9842en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134127-
dc.description.abstractAimsWe sought to determine whether inter-or intra-ventricular systolic dyssynchrony contributes to the occurrence of elevated pulmonary artery systolic pressure (PASP) in patients with coronary artery disease (CAD).Methods and resultsOne hundred and fifty-three consecutive CAD patients with preserved left ventricular ejection fraction (LVEF >40) were enrolled. Detailed echocardiography was performed to measure PASP, inter-ventricular dyssynchrony (Ts-RL: time difference between lateral and right free wall), and intra-ventricular dyssynchrony (Ts-SD, standard deviation of time to peak systolic velocity of 12 LV segments; Ts-12, maximal difference in Ts between any 2 of 12 LV segments; Ts-6-basal, maximal difference in Ts between any 2 of 6 basal LV segments). Elevated PASP (>35 mmHg) was confirmed in 46 patients who had significantly prolonged intra-ventricular dyssynchrony (Ts-SD: 49.9 ± 19.6 vs.37.9 ± 19.8 ms; Ts-12: 147.9 ± 56.4 vs.110.9 ± 53.9 ms; Ts-6-basal: 114.2 ± 51.9 vs. 85.7 ± 48.5 ms, all P < 0.01) and inter-ventricular dyssynchrony (Ts-RL: 78.7 ± 46.4 vs. 62.7 ± 34.3 ms, P = 0.019) compared with those without elevated PASP. Indexes of intra-and inter-ventricular dyssynchrony and LV filling pressure (E/e′) were significantly correlated with PASP. Multivariate analysis showed that left atrial dimension [odds ratio (OR) 4.23, 95 confidence interval (CI) 1.64-10.90], E/e′ septal (OR 1.15, 95 CI 1.04-1.27), pulmonary vascular resistance (OR 5.38, 95 CI 1.55-18.74), and Ts-RL (OR 1.02, 95 CI 1.01-1.03) were independent predictors for the occurrence of elevated PASP (all P < 0.05).ConclusionElevated PASP is common in CAD patients with preserved LVEF and is associated with LV diastolic dysfunction and LV mechanical dyssynchrony. © 2010 The Author.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://eurjhf.oxfordjournals.orgen_HK
dc.relation.ispartofEuropean Journal of Heart Failureen_HK
dc.subjectCoronary artery diseaseen_HK
dc.subjectPulmonary artery systolic pressureen_HK
dc.subjectVentricular dyssynchronyen_HK
dc.subject.meshBlood Pressure-
dc.subject.meshCoronary Artery Disease - ultrasonography-
dc.subject.meshHeart Ventricles - ultrasonography-
dc.subject.meshHypertension - ultrasonography-
dc.subject.meshPulmonary Artery - ultrasonography-
dc.titleElevated pulmonary artery systolic pressure in patients with coronary artery disease and left ventricular dyssynchronyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1388-9842&volume=12&issue=10&spage=1067&epage=1075&date=2010&atitle=Elevated+pulmonary+artery+systolic+pressure+in+patients+with+coronary+artery+disease+and+left+ventricular+dyssynchrony-
dc.identifier.emailWang, M:meiwang@hkucc.hku.hken_HK
dc.identifier.emailYiu, KH:khkyiu@hku.hken_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityWang, M=rp00281en_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/eurjhf/hfq125en_HK
dc.identifier.pmid20675663-
dc.identifier.scopuseid_2-s2.0-77957221507en_HK
dc.identifier.hkuros169689-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77957221507&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1067en_HK
dc.identifier.epage1075en_HK
dc.identifier.isiWOS:000282172000012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYan, GH=36544693600en_HK
dc.identifier.scopusauthoridWang, M=7406690398en_HK
dc.identifier.scopusauthoridYue, WS=36106565300en_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridLee, SWL=7601396808en_HK
dc.identifier.scopusauthoridLau, CP=35275317200en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats