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Article: Smoking is associated with depletion of circulating endothelial progenitor cells and elevated pulmonary artery systolic pressure in patients with coronary artery disease

TitleSmoking is associated with depletion of circulating endothelial progenitor cells and elevated pulmonary artery systolic pressure in patients with coronary artery disease
Authors
KeywordsAdult
Aged
Article
Coronary Artery Disease
Disease Association
Doppler Echocardiography
Endothelial Progenitor Cell
Endothelium Cell
Female
Flow Cytometry
Heart Right Ventricle
Human
Hypertension
Lung Artery Pressure
Lung Vascular Resistance
Major Clinical Study
Male
Priority Journal
Pulmonary Hypertension
Smoking
Stem Cell
Systolic Blood Pressure
Issue Date2010
PublisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/
Citation
American Journal Of Cardiology, 2010, v. 106 n. 9, p. 1248-1254 How to Cite?
AbstractSmoking is associated with depletion of endothelial progenitor cells (EPCs) and may subsequently contribute to the development of vascular dysfunction. The aim of this study was to investigate the relation between circulating EPCs and pulmonary artery systolic pressure (PASP) as determined by flow cytometry and echocardiography in 174 patients (mean age 69 ± 9 years, 95 smokers) with established coronary artery disease. Smokers had significantly lower circulating log CD34/KDR + (0.86 ± 0.03 vs 0.96 ± 0.03 × 10 -3/ml, p = 0.032) and log CD133/KDR + (0.68 ± 0.03 vs 0.82 ± 0.03 × 10 -3/ml, p = 0.002) EPCs and a higher prevalence of elevated PASP >30 mm Hg (52% vs 30%, p = 0.001) than nonsmokers. Smokers with elevated PASP also had significantly lower circulating log CD34/KDR + (0.74 ± 0.04 vs 0.88 ± 0.06 × 10 -3/ml, p <0.001) and log CD133/KDR + (0.61 ± 0.04 vs 0.78 ± 0.05 × 10 -3/ml, p <0.001) EPCs, higher pulmonary vascular resistance, and larger right ventricular dimensions with impaired function (all p values <0.05). Log CD34/KDR + and log CD133/KDR + EPC counts were significantly and negatively correlated with PASP (r = -0.30, p <0.001, and r = -0.34, p <0.001, respectively) and pulmonary vascular resistance (r = -0.29, p = 0.002, and r = -0.18, p = 0.013, respectively). In conclusion, this study demonstrated that in patients with coronary artery disease, smoking was associated with a reduced number of EPCs and elevated PASP. This suggests that in smokers, depletion of circulating EPCs might be linked to the occurrence of pulmonary vascular dysfunction. © 2010 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/134125
ISSN
2015 Impact Factor: 3.154
2015 SCImago Journal Rankings: 2.063
ISI Accession Number ID
Funding AgencyGrant Number
Research Grant Council of Hong KongHKU 7777/07M
HKU 7775/08M
Funding Information:

This study was supported by the General Research Fund of Research Grant Council of Hong Kong (HKU 7777/07M and HKU 7775/08M)

References

 

DC FieldValueLanguage
dc.contributor.authorYue, WSen_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorYan, GHen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorYin, Len_HK
dc.contributor.authorLee, SWLen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2011-06-13T07:19:52Z-
dc.date.available2011-06-13T07:19:52Z-
dc.date.issued2010en_HK
dc.identifier.citationAmerican Journal Of Cardiology, 2010, v. 106 n. 9, p. 1248-1254en_HK
dc.identifier.issn0002-9149en_HK
dc.identifier.urihttp://hdl.handle.net/10722/134125-
dc.description.abstractSmoking is associated with depletion of endothelial progenitor cells (EPCs) and may subsequently contribute to the development of vascular dysfunction. The aim of this study was to investigate the relation between circulating EPCs and pulmonary artery systolic pressure (PASP) as determined by flow cytometry and echocardiography in 174 patients (mean age 69 ± 9 years, 95 smokers) with established coronary artery disease. Smokers had significantly lower circulating log CD34/KDR + (0.86 ± 0.03 vs 0.96 ± 0.03 × 10 -3/ml, p = 0.032) and log CD133/KDR + (0.68 ± 0.03 vs 0.82 ± 0.03 × 10 -3/ml, p = 0.002) EPCs and a higher prevalence of elevated PASP >30 mm Hg (52% vs 30%, p = 0.001) than nonsmokers. Smokers with elevated PASP also had significantly lower circulating log CD34/KDR + (0.74 ± 0.04 vs 0.88 ± 0.06 × 10 -3/ml, p <0.001) and log CD133/KDR + (0.61 ± 0.04 vs 0.78 ± 0.05 × 10 -3/ml, p <0.001) EPCs, higher pulmonary vascular resistance, and larger right ventricular dimensions with impaired function (all p values <0.05). Log CD34/KDR + and log CD133/KDR + EPC counts were significantly and negatively correlated with PASP (r = -0.30, p <0.001, and r = -0.34, p <0.001, respectively) and pulmonary vascular resistance (r = -0.29, p = 0.002, and r = -0.18, p = 0.013, respectively). In conclusion, this study demonstrated that in patients with coronary artery disease, smoking was associated with a reduced number of EPCs and elevated PASP. This suggests that in smokers, depletion of circulating EPCs might be linked to the occurrence of pulmonary vascular dysfunction. © 2010 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/en_HK
dc.relation.ispartofAmerican Journal of Cardiologyen_HK
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectArticleen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectDisease Associationen_US
dc.subjectDoppler Echocardiographyen_US
dc.subjectEndothelial Progenitor Cellen_US
dc.subjectEndothelium Cellen_US
dc.subjectFemaleen_US
dc.subjectFlow Cytometryen_US
dc.subjectHeart Right Ventricleen_US
dc.subjectHumanen_US
dc.subjectHypertensionen_US
dc.subjectLung Artery Pressureen_US
dc.subjectLung Vascular Resistanceen_US
dc.subjectMajor Clinical Studyen_US
dc.subjectMaleen_US
dc.subjectPriority Journalen_US
dc.subjectPulmonary Hypertensionen_US
dc.subjectSmokingen_US
dc.subjectStem Cellen_US
dc.subjectSystolic Blood Pressureen_US
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshBlood Pressureen_HK
dc.subject.meshBody Mass Indexen_HK
dc.subject.meshCoronary Artery Disease - physiopathologyen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshDiabetes Mellitus - physiopathologyen_HK
dc.subject.meshEchocardiography, Doppleren_HK
dc.subject.meshEndothelial Cellsen_HK
dc.subject.meshEndothelium, Vascular - physiopathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFlow Cytometryen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypercholesterolemia - physiopathologyen_HK
dc.subject.meshHypertension, Pulmonary - physiopathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPulmonary Arteryen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSmoking - adverse effectsen_HK
dc.subject.meshStem Cellsen_HK
dc.subject.meshVascular Resistanceen_HK
dc.titleSmoking is associated with depletion of circulating endothelial progenitor cells and elevated pulmonary artery systolic pressure in patients with coronary artery diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailWang, M:meiwang@hkucc.hku.hken_HK
dc.identifier.emailYiu, KH:khkyiu@hku.hken_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityWang, M=rp00281en_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.amjcard.2010.06.045en_HK
dc.identifier.pmid21029820-
dc.identifier.scopuseid_2-s2.0-78049282754en_HK
dc.identifier.hkuros171982-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78049282754&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume106en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1248en_HK
dc.identifier.epage1254en_HK
dc.identifier.isiWOS:000284177200009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYue, WS=36106565300en_HK
dc.identifier.scopusauthoridWang, M=7406690398en_HK
dc.identifier.scopusauthoridYan, GH=36544693600en_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridYin, L=7203060719en_HK
dc.identifier.scopusauthoridLee, SWL=7601396808en_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.citeulike7884706-

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