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Article: Adverse systemic arterial function in patients with selenium deficiency
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TitleAdverse systemic arterial function in patients with selenium deficiency
 
AuthorsChan, YH1
Siu, CW1 1
Yiu, KH1
Chan, HT1
Li, SW3
Tam, S2
Cheung, BM1
Lau, CP1
Lam, TH1
Tse, HF1 1
 
Keywordsarterial stiffness
nutrition
secondary prevention
Selenium deficiency
vascular function
 
Issue Date2012
 
PublisherEditions S E R D I. The Journal's web site is located at http://www.springer.com/medicine/family/journal/12603
 
CitationJournal Of Nutrition, Health And Aging, 2012, v. 16 n. 1, p. 85-88 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s12603-011-0086-5
 
AbstractBackground: Experimental studies have shown that selenium is involved in the synthesis of selenoproteins which might contribute to cardiovascular protection. However, the relationship between selenium deficiency and vascular function in clinical context remains unknown. Objective: To investigate for any relationship between selenium deficiency and systemic arterial function in patients with high risk of vascular events. Design: Cross-sectional study. Setting and Participants: 306 consecutive patients with high risk for cardiovascular events (coronary artery disease 35%, acute/recurrent ischemic stroke 40%, diabetes mellitus 54%) followed up at internal medicine outpatient clinics. Measurements: Non-invasive brachial-ankle pulse wave velocity (PWV) was determined using vascular profiling system (VP-2000). Long-term intake of selenium was determined by a validated food frequency questionnaire. Results: Mean daily selenium intake was 59.5 ± 52.1 mcg/day, and mean PWV was 1782.4 ± 418.4 cm/s. Patients with selenium intake <10th percentile had significantly higher PWV as compared to patients with intake 10th percentile (1968.2 ± 648.9 cm/s versus 1762.2 ± 381.6 cm/s, P=0.010). After adjusting for potential confounders including age, gender, history of hypertension, hyperlipidemia, diabetes and cardiovascular disease, smoking status, use of cardiovascular medications, waist-hip ratio, education/financial status, physical activity, calorie intake and intake of antioxidant vitamins, deficient selenium intake <10th percentile remained independently predictive of increased PWV by +363.4 cm/s [95% CI: 68.1 to 658.6, P=0.016, relative increase 21%]. Conclusions: Selenium deficiency is associated with adverse arterial function in patients with high risk for vascular events. © 2012 The Journal of Nutrition, Health & Aging.
 
ISSN1279-7707
2012 Impact Factor: 2.394
2012 SCImago Journal Rankings: 0.747
 
DOIhttp://dx.doi.org/10.1007/s12603-011-0086-5
 
ISI Accession Number IDWOS:000300523500013
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChan, YH
 
dc.contributor.authorSiu, CW
 
dc.contributor.authorYiu, KH
 
dc.contributor.authorChan, HT
 
dc.contributor.authorLi, SW
 
dc.contributor.authorTam, S
 
dc.contributor.authorCheung, BM
 
dc.contributor.authorLau, CP
 
dc.contributor.authorLam, TH
 
dc.contributor.authorTse, HF
 
dc.date.accessioned2011-06-13T07:19:50Z
 
dc.date.available2011-06-13T07:19:50Z
 
dc.date.issued2012
 
dc.description.abstractBackground: Experimental studies have shown that selenium is involved in the synthesis of selenoproteins which might contribute to cardiovascular protection. However, the relationship between selenium deficiency and vascular function in clinical context remains unknown. Objective: To investigate for any relationship between selenium deficiency and systemic arterial function in patients with high risk of vascular events. Design: Cross-sectional study. Setting and Participants: 306 consecutive patients with high risk for cardiovascular events (coronary artery disease 35%, acute/recurrent ischemic stroke 40%, diabetes mellitus 54%) followed up at internal medicine outpatient clinics. Measurements: Non-invasive brachial-ankle pulse wave velocity (PWV) was determined using vascular profiling system (VP-2000). Long-term intake of selenium was determined by a validated food frequency questionnaire. Results: Mean daily selenium intake was 59.5 ± 52.1 mcg/day, and mean PWV was 1782.4 ± 418.4 cm/s. Patients with selenium intake <10th percentile had significantly higher PWV as compared to patients with intake 10th percentile (1968.2 ± 648.9 cm/s versus 1762.2 ± 381.6 cm/s, P=0.010). After adjusting for potential confounders including age, gender, history of hypertension, hyperlipidemia, diabetes and cardiovascular disease, smoking status, use of cardiovascular medications, waist-hip ratio, education/financial status, physical activity, calorie intake and intake of antioxidant vitamins, deficient selenium intake <10th percentile remained independently predictive of increased PWV by +363.4 cm/s [95% CI: 68.1 to 658.6, P=0.016, relative increase 21%]. Conclusions: Selenium deficiency is associated with adverse arterial function in patients with high risk for vascular events. © 2012 The Journal of Nutrition, Health & Aging.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Nutrition, Health And Aging, 2012, v. 16 n. 1, p. 85-88 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s12603-011-0086-5
 
dc.identifier.doihttp://dx.doi.org/10.1007/s12603-011-0086-5
 
dc.identifier.epage88
 
dc.identifier.hkuros194717
 
dc.identifier.isiWOS:000300523500013
 
dc.identifier.issn1279-7707
2012 Impact Factor: 2.394
2012 SCImago Journal Rankings: 0.747
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid22238006
 
dc.identifier.scopuseid_2-s2.0-84856361555
 
dc.identifier.spage85
 
dc.identifier.urihttp://hdl.handle.net/10722/134124
 
dc.identifier.volume16
 
dc.languageeng
 
dc.publisherEditions S E R D I. The Journal's web site is located at http://www.springer.com/medicine/family/journal/12603
 
dc.publisher.placeFrance
 
dc.relation.ispartofJournal of Nutrition, Health and Aging
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe original publication is available at www.springerlink.com
 
dc.subject.meshAged
 
dc.subject.meshAnkle Brachial Index
 
dc.subject.meshBlood Flow Velocity
 
dc.subject.meshBrachial Artery - physiopathology
 
dc.subject.meshCardiovascular Diseases - etiology
 
dc.subject.meshConfounding Factors (Epidemiology)
 
dc.subject.meshCross-Sectional Studies
 
dc.subject.meshDeficiency Diseases - complications - physiopathology
 
dc.subject.meshDiet Records
 
dc.subject.meshEnergy Intake
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNutrition Assessment
 
dc.subject.meshQuestionnaires
 
dc.subject.meshSelenium - administration & dosage - deficiency
 
dc.subject.meshTrace Elements - deficiency
 
dc.subject.meshVascular Diseases - etiology - physiopathology
 
dc.subjectarterial stiffness
 
dc.subjectnutrition
 
dc.subjectsecondary prevention
 
dc.subjectSelenium deficiency
 
dc.subjectvascular function
 
dc.titleAdverse systemic arterial function in patients with selenium deficiency
 
dc.typeArticle
 
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<contributor.author>Siu, CW</contributor.author>
<contributor.author>Yiu, KH</contributor.author>
<contributor.author>Chan, HT</contributor.author>
<contributor.author>Li, SW</contributor.author>
<contributor.author>Tam, S</contributor.author>
<contributor.author>Cheung, BM</contributor.author>
<contributor.author>Lau, CP</contributor.author>
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<description.abstract>Background: Experimental studies have shown that selenium is involved in the synthesis of selenoproteins which might contribute to cardiovascular protection. However, the relationship between selenium deficiency and vascular function in clinical context remains unknown. Objective: To investigate for any relationship between selenium deficiency and systemic arterial function in patients with high risk of vascular events. Design: Cross-sectional study. Setting and Participants: 306 consecutive patients with high risk for cardiovascular events (coronary artery disease 35%, acute/recurrent ischemic stroke 40%, diabetes mellitus 54%) followed up at internal medicine outpatient clinics. Measurements: Non-invasive brachial-ankle pulse wave velocity (PWV) was determined using vascular profiling system (VP-2000). Long-term intake of selenium was determined by a validated food frequency questionnaire. Results: Mean daily selenium intake was 59.5 &#177; 52.1 mcg/day, and mean PWV was 1782.4 &#177; 418.4 cm/s. Patients with selenium intake &lt;10th percentile had significantly higher PWV as compared to patients with intake 10th percentile (1968.2 &#177; 648.9 cm/s versus 1762.2 &#177; 381.6 cm/s, P=0.010). After adjusting for potential confounders including age, gender, history of hypertension, hyperlipidemia, diabetes and cardiovascular disease, smoking status, use of cardiovascular medications, waist-hip ratio, education/financial status, physical activity, calorie intake and intake of antioxidant vitamins, deficient selenium intake &lt;10th percentile remained independently predictive of increased PWV by +363.4 cm/s [95% CI: 68.1 to 658.6, P=0.016, relative increase 21%]. Conclusions: Selenium deficiency is associated with adverse arterial function in patients with high risk for vascular events. &#169; 2012 The Journal of Nutrition, Health &amp; Aging.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong
  3. Tung Wah Hospital