Article: Variation in the AU(AT)-rich element within the 3'-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians

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TitleVariation in the AU(AT)-rich element within the 3'-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians
AuthorsHegele, RA2 3
Harris, SB1 3
Zinman, B4
Wang, J3
Cao, H3
Hanley, AJG4
Tsui, LC5
Scherer, SW5
Issue Date1998
PublisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
CitationJournal Of Clinical Endocrinology And Metabolism, 1998, v. 83 n. 11, p. 3980-3983 [How to Cite?]
AbstractWe are investigating associations between variations in candidate genes on chromosome 7q and diabetes-related phenotypes in Canadian Oji-Cree. One of these genes encodes the skeletal muscle regulatory G subunit of the glycogen- associated form of protein phosphatase 1 (PPPIR3), which may play a key role in muscle glycogen metabolism. There is a common 5-bp insertion-deletion polymorphism in a messenger ribonucleic acid-stabilizing AU(AT)-rich element within the 3'-untranslated region (UTR) of PPPIR3. The D allele had a frequency of 0.30 in the Oji-Cree. We found that this 3'-UTR variation of PPP1R3 was significantly associated with variation in 2-h postprandial glucose in adult Oji-Cree with type 2 diabetes or impaired glucose tolerance (IGT). Specifically, Oji-Cree with diabetes or IGT who were D/D homozygotes had significantly lower 2-h postprandial plasma glucose than subjects with the other genotypes. There was no association of the PPPIR3 genotype either with the presence of type 2 diabetes or IGT or with other quantitative traits in this sample. These findings suggest that common PPPIR3 3'-UTR variation that potentially affects messenger ribonucleic acid stability is associated with variation in glycemia in Oji-Cree subjects with type 2 diabetes.
ISSN0021-972X
2011 Impact Factor: 5.967
2011 SCImago Journal Rankings: 0.579
ISI Accession Number IDWOS:000076938500037
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorHegele, RA
dc.contributor.authorHarris, SB
dc.contributor.authorZinman, B
dc.contributor.authorWang, J
dc.contributor.authorCao, H
dc.contributor.authorHanley, AJG
dc.contributor.authorTsui, LC
dc.contributor.authorScherer, SW
dc.date.accessioned2011-06-07T04:41:35Z
dc.date.available2011-06-07T04:41:35Z
dc.date.issued1998
dc.description.abstractWe are investigating associations between variations in candidate genes on chromosome 7q and diabetes-related phenotypes in Canadian Oji-Cree. One of these genes encodes the skeletal muscle regulatory G subunit of the glycogen- associated form of protein phosphatase 1 (PPPIR3), which may play a key role in muscle glycogen metabolism. There is a common 5-bp insertion-deletion polymorphism in a messenger ribonucleic acid-stabilizing AU(AT)-rich element within the 3'-untranslated region (UTR) of PPPIR3. The D allele had a frequency of 0.30 in the Oji-Cree. We found that this 3'-UTR variation of PPP1R3 was significantly associated with variation in 2-h postprandial glucose in adult Oji-Cree with type 2 diabetes or impaired glucose tolerance (IGT). Specifically, Oji-Cree with diabetes or IGT who were D/D homozygotes had significantly lower 2-h postprandial plasma glucose than subjects with the other genotypes. There was no association of the PPPIR3 genotype either with the presence of type 2 diabetes or IGT or with other quantitative traits in this sample. These findings suggest that common PPPIR3 3'-UTR variation that potentially affects messenger ribonucleic acid stability is associated with variation in glycemia in Oji-Cree subjects with type 2 diabetes.
dc.description.naturelink_to_OA_fulltext
dc.identifier.citationJournal Of Clinical Endocrinology And Metabolism, 1998, v. 83 n. 11, p. 3980-3983 [How to Cite?]
dc.identifier.epage3983
dc.identifier.hkuros121093
dc.identifier.isiWOS:000076938500037
dc.identifier.issn0021-972X
2011 Impact Factor: 5.967
2011 SCImago Journal Rankings: 0.579
dc.identifier.issue11
dc.identifier.openurl
dc.identifier.pmid9814479
dc.identifier.scopuseid_2-s2.0-0031763878
dc.identifier.spage3980
dc.identifier.urihttp://hdl.handle.net/10722/133921
dc.identifier.volume83
dc.languageeng
dc.publisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolism
dc.relation.referencesReferences in Scopus
dc.subject.mesh3' Untranslated Regions
dc.subject.meshAmerican Native Continental Ancestry Group - genetics
dc.subject.meshBase Pairing
dc.subject.meshBlood Glucose - metabolism
dc.subject.meshPhosphoprotein Phosphatases - genetics
dc.titleVariation in the AU(AT)-rich element within the 3'-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians
dc.typeArticle
Author Affiliations
  1. null
  2. Robarts Research Institute
  3. Western University
  4. Samuel Lunenfeld Research Institute
  5. Hospital for Sick Children, Toronto