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Article: Variation in the AU(AT)-rich element within the 3'-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians

TitleVariation in the AU(AT)-rich element within the 3'-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians
Authors
Issue Date1998
PublisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
Citation
Journal Of Clinical Endocrinology And Metabolism, 1998, v. 83 n. 11, p. 3980-3983 How to Cite?
AbstractWe are investigating associations between variations in candidate genes on chromosome 7q and diabetes-related phenotypes in Canadian Oji-Cree. One of these genes encodes the skeletal muscle regulatory G subunit of the glycogen- associated form of protein phosphatase 1 (PPPIR3), which may play a key role in muscle glycogen metabolism. There is a common 5-bp insertion-deletion polymorphism in a messenger ribonucleic acid-stabilizing AU(AT)-rich element within the 3'-untranslated region (UTR) of PPPIR3. The D allele had a frequency of 0.30 in the Oji-Cree. We found that this 3'-UTR variation of PPP1R3 was significantly associated with variation in 2-h postprandial glucose in adult Oji-Cree with type 2 diabetes or impaired glucose tolerance (IGT). Specifically, Oji-Cree with diabetes or IGT who were D/D homozygotes had significantly lower 2-h postprandial plasma glucose than subjects with the other genotypes. There was no association of the PPPIR3 genotype either with the presence of type 2 diabetes or IGT or with other quantitative traits in this sample. These findings suggest that common PPPIR3 3'-UTR variation that potentially affects messenger ribonucleic acid stability is associated with variation in glycemia in Oji-Cree subjects with type 2 diabetes.
Persistent Identifierhttp://hdl.handle.net/10722/133921
ISSN
2014 Impact Factor: 6.209
2014 SCImago Journal Rankings: 2.625
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHegele, RAen_HK
dc.contributor.authorHarris, SBen_HK
dc.contributor.authorZinman, Ben_HK
dc.contributor.authorWang, Jen_HK
dc.contributor.authorCao, Hen_HK
dc.contributor.authorHanley, AJGen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorScherer, SWen_HK
dc.date.accessioned2011-06-07T04:41:35Z-
dc.date.available2011-06-07T04:41:35Z-
dc.date.issued1998en_HK
dc.identifier.citationJournal Of Clinical Endocrinology And Metabolism, 1998, v. 83 n. 11, p. 3980-3983en_HK
dc.identifier.issn0021-972Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/133921-
dc.description.abstractWe are investigating associations between variations in candidate genes on chromosome 7q and diabetes-related phenotypes in Canadian Oji-Cree. One of these genes encodes the skeletal muscle regulatory G subunit of the glycogen- associated form of protein phosphatase 1 (PPPIR3), which may play a key role in muscle glycogen metabolism. There is a common 5-bp insertion-deletion polymorphism in a messenger ribonucleic acid-stabilizing AU(AT)-rich element within the 3'-untranslated region (UTR) of PPPIR3. The D allele had a frequency of 0.30 in the Oji-Cree. We found that this 3'-UTR variation of PPP1R3 was significantly associated with variation in 2-h postprandial glucose in adult Oji-Cree with type 2 diabetes or impaired glucose tolerance (IGT). Specifically, Oji-Cree with diabetes or IGT who were D/D homozygotes had significantly lower 2-h postprandial plasma glucose than subjects with the other genotypes. There was no association of the PPPIR3 genotype either with the presence of type 2 diabetes or IGT or with other quantitative traits in this sample. These findings suggest that common PPPIR3 3'-UTR variation that potentially affects messenger ribonucleic acid stability is associated with variation in glycemia in Oji-Cree subjects with type 2 diabetes.en_HK
dc.languageeng-
dc.publisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.orgen_HK
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolismen_HK
dc.subject.mesh3' Untranslated Regions-
dc.subject.meshAmerican Native Continental Ancestry Group - genetics-
dc.subject.meshBase Pairing-
dc.subject.meshBlood Glucose - metabolism-
dc.subject.meshPhosphoprotein Phosphatases - genetics-
dc.titleVariation in the AU(AT)-rich element within the 3'-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadiansen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-972X&volume=83&issue=11&spage=3980&epage=3983&date=1998&atitle=Variation+in+the+AU(AT)-rich+element+within+the+3%27-untranslated+region+of+PPP1R3+is+associated+with+variation+in+plasma+glucose+in+aboriginal+Canadians-
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid9814479en_HK
dc.identifier.scopuseid_2-s2.0-0031763878en_HK
dc.identifier.hkuros121093-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031763878&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume83en_HK
dc.identifier.issue11en_HK
dc.identifier.spage3980en_HK
dc.identifier.epage3983en_HK
dc.identifier.isiWOS:000076938500037-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHegele, RA=35399481100en_HK
dc.identifier.scopusauthoridHarris, SB=35500171900en_HK
dc.identifier.scopusauthoridZinman, B=7102090193en_HK
dc.identifier.scopusauthoridWang, J=36078145500en_HK
dc.identifier.scopusauthoridCao, H=7403346385en_HK
dc.identifier.scopusauthoridHanley, AJG=7005599486en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridScherer, SW=35374654500en_HK

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