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Article: Variation in the AU(AT)-rich element within the 3'-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians
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TitleVariation in the AU(AT)-rich element within the 3'-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians
 
AuthorsHegele, RA3 2
Harris, SB3 1
Zinman, B4
Wang, J3
Cao, H3
Hanley, AJG4
Tsui, LC5
Scherer, SW5
 
Issue Date1998
 
PublisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
 
CitationJournal Of Clinical Endocrinology And Metabolism, 1998, v. 83 n. 11, p. 3980-3983 [How to Cite?]
 
AbstractWe are investigating associations between variations in candidate genes on chromosome 7q and diabetes-related phenotypes in Canadian Oji-Cree. One of these genes encodes the skeletal muscle regulatory G subunit of the glycogen- associated form of protein phosphatase 1 (PPPIR3), which may play a key role in muscle glycogen metabolism. There is a common 5-bp insertion-deletion polymorphism in a messenger ribonucleic acid-stabilizing AU(AT)-rich element within the 3'-untranslated region (UTR) of PPPIR3. The D allele had a frequency of 0.30 in the Oji-Cree. We found that this 3'-UTR variation of PPP1R3 was significantly associated with variation in 2-h postprandial glucose in adult Oji-Cree with type 2 diabetes or impaired glucose tolerance (IGT). Specifically, Oji-Cree with diabetes or IGT who were D/D homozygotes had significantly lower 2-h postprandial plasma glucose than subjects with the other genotypes. There was no association of the PPPIR3 genotype either with the presence of type 2 diabetes or IGT or with other quantitative traits in this sample. These findings suggest that common PPPIR3 3'-UTR variation that potentially affects messenger ribonucleic acid stability is associated with variation in glycemia in Oji-Cree subjects with type 2 diabetes.
 
ISSN0021-972X
2012 Impact Factor: 6.43
2012 SCImago Journal Rankings: 2.555
 
ISI Accession Number IDWOS:000076938500037
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHegele, RA
 
dc.contributor.authorHarris, SB
 
dc.contributor.authorZinman, B
 
dc.contributor.authorWang, J
 
dc.contributor.authorCao, H
 
dc.contributor.authorHanley, AJG
 
dc.contributor.authorTsui, LC
 
dc.contributor.authorScherer, SW
 
dc.date.accessioned2011-06-07T04:41:35Z
 
dc.date.available2011-06-07T04:41:35Z
 
dc.date.issued1998
 
dc.description.abstractWe are investigating associations between variations in candidate genes on chromosome 7q and diabetes-related phenotypes in Canadian Oji-Cree. One of these genes encodes the skeletal muscle regulatory G subunit of the glycogen- associated form of protein phosphatase 1 (PPPIR3), which may play a key role in muscle glycogen metabolism. There is a common 5-bp insertion-deletion polymorphism in a messenger ribonucleic acid-stabilizing AU(AT)-rich element within the 3'-untranslated region (UTR) of PPPIR3. The D allele had a frequency of 0.30 in the Oji-Cree. We found that this 3'-UTR variation of PPP1R3 was significantly associated with variation in 2-h postprandial glucose in adult Oji-Cree with type 2 diabetes or impaired glucose tolerance (IGT). Specifically, Oji-Cree with diabetes or IGT who were D/D homozygotes had significantly lower 2-h postprandial plasma glucose than subjects with the other genotypes. There was no association of the PPPIR3 genotype either with the presence of type 2 diabetes or IGT or with other quantitative traits in this sample. These findings suggest that common PPPIR3 3'-UTR variation that potentially affects messenger ribonucleic acid stability is associated with variation in glycemia in Oji-Cree subjects with type 2 diabetes.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationJournal Of Clinical Endocrinology And Metabolism, 1998, v. 83 n. 11, p. 3980-3983 [How to Cite?]
 
dc.identifier.epage3983
 
dc.identifier.hkuros121093
 
dc.identifier.isiWOS:000076938500037
 
dc.identifier.issn0021-972X
2012 Impact Factor: 6.43
2012 SCImago Journal Rankings: 2.555
 
dc.identifier.issue11
 
dc.identifier.openurl
 
dc.identifier.pmid9814479
 
dc.identifier.scopuseid_2-s2.0-0031763878
 
dc.identifier.spage3980
 
dc.identifier.urihttp://hdl.handle.net/10722/133921
 
dc.identifier.volume83
 
dc.languageeng
 
dc.publisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolism
 
dc.relation.referencesReferences in Scopus
 
dc.subject.mesh3' Untranslated Regions
 
dc.subject.meshAmerican Native Continental Ancestry Group - genetics
 
dc.subject.meshBase Pairing
 
dc.subject.meshBlood Glucose - metabolism
 
dc.subject.meshPhosphoprotein Phosphatases - genetics
 
dc.titleVariation in the AU(AT)-rich element within the 3'-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians
 
dc.typeArticle
 
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Author Affiliations
  1. null
  2. Robarts Research Institute
  3. Western University
  4. Samuel Lunenfeld Research Institute
  5. Hospital for Sick Children University of Toronto