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Article: Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development

TitleSpecific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development
Authors
KeywordsGli
Indian hedgehog
Mouse
Skeletal development
Sonic hedgehog
Issue Date1997
PublisherThe Company of Biologists Ltd. The Journal's web site is located at http://dev.biologists.org
Citation
Development, 1997, v. 124 n. 1, p. 113-123 How to Cite?
AbstractThe correct patterning of vertebrate skeletal elements is controlled by inductive interactions. Two vertebrate hedgehog proteins, Sonic hedgehog and Indian hedgehog, have been implicated in skeletal development. During somite differentiation and limb development, Sonic hedgehog functions as an inductive signal from the notochord, floor plate and zone of polarizing activity. Later in skeletogenesis, Indian hedgehog functions as a regulator of chondrogenesis during endochondral ossification. The vertebrate Gli zinc finger proteins are putative transcription factors that respond to Hedgehog signaling. In Drosophila, the Gli homolog cubitus interruptus is required for the activation of hedgehog targets and also functions as a repressor of hedgehog expression. We show here that Gli2 mutant mice exhibit severe skeletal abnormalities including cleft palate, tooth defects, absence of vertebral body and intervertebral discs, and shortened limbs and sternum. Interestingly, Gli2 and Gli3 mutant mice exhibit different subsets of skeletal defects indicating that they implement specific functions in the development of the neural crest, somite and lateral plate mesoderm derivatives. Although Gli2 and Gli3 are not functionally equivalent, double mutant analysis indicates that, in addition to their specific roles, they also serve redundant functions during skeletal development. The role of Gli2 and Gli3 in Hedgehog signaling during skeletal development is discussed.
Persistent Identifierhttp://hdl.handle.net/10722/133919
ISSN
2015 Impact Factor: 6.059
2015 SCImago Journal Rankings: 5.239
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMo, Ren_HK
dc.contributor.authorFreer, AMen_HK
dc.contributor.authorZinyk, DLen_HK
dc.contributor.authorCrackower, MAen_HK
dc.contributor.authorMichaud, Jen_HK
dc.contributor.authorHeng, HHQen_HK
dc.contributor.authorChik, KWen_HK
dc.contributor.authorShi, XMen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorCheng, SHen_HK
dc.contributor.authorJoyner, ALen_HK
dc.contributor.authorHui, CCen_HK
dc.date.accessioned2011-06-07T04:03:25Z-
dc.date.available2011-06-07T04:03:25Z-
dc.date.issued1997en_HK
dc.identifier.citationDevelopment, 1997, v. 124 n. 1, p. 113-123en_HK
dc.identifier.issn0950-1991en_HK
dc.identifier.urihttp://hdl.handle.net/10722/133919-
dc.description.abstractThe correct patterning of vertebrate skeletal elements is controlled by inductive interactions. Two vertebrate hedgehog proteins, Sonic hedgehog and Indian hedgehog, have been implicated in skeletal development. During somite differentiation and limb development, Sonic hedgehog functions as an inductive signal from the notochord, floor plate and zone of polarizing activity. Later in skeletogenesis, Indian hedgehog functions as a regulator of chondrogenesis during endochondral ossification. The vertebrate Gli zinc finger proteins are putative transcription factors that respond to Hedgehog signaling. In Drosophila, the Gli homolog cubitus interruptus is required for the activation of hedgehog targets and also functions as a repressor of hedgehog expression. We show here that Gli2 mutant mice exhibit severe skeletal abnormalities including cleft palate, tooth defects, absence of vertebral body and intervertebral discs, and shortened limbs and sternum. Interestingly, Gli2 and Gli3 mutant mice exhibit different subsets of skeletal defects indicating that they implement specific functions in the development of the neural crest, somite and lateral plate mesoderm derivatives. Although Gli2 and Gli3 are not functionally equivalent, double mutant analysis indicates that, in addition to their specific roles, they also serve redundant functions during skeletal development. The role of Gli2 and Gli3 in Hedgehog signaling during skeletal development is discussed.en_HK
dc.languageeng-
dc.publisherThe Company of Biologists Ltd. The Journal's web site is located at http://dev.biologists.orgen_HK
dc.relation.ispartofDevelopmenten_HK
dc.subjectGlien_HK
dc.subjectIndian hedgehogen_HK
dc.subjectMouseen_HK
dc.subjectSkeletal developmenten_HK
dc.subjectSonic hedgehogen_HK
dc.subject.meshBone and Bones - abnormalities-
dc.subject.meshCraniofacial Abnormalities - genetics-
dc.subject.meshDNA-Binding Proteins - biosynthesis - genetics-
dc.subject.meshEmbryonic and Fetal Development-
dc.subject.meshMuscle, Skeletal - embryology - metabolism-
dc.titleSpecific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and developmenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0950-1991&volume=124&issue=1&spage=113&epage=123&date=1997&atitle=Specific+and+redundant+functions+of+Gli2+and+Gli3+zinc+finger+genes+in+skeletal+patterning+and+development-
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid9006072-
dc.identifier.scopuseid_2-s2.0-0031020221en_HK
dc.identifier.hkuros121048-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031020221&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume124en_HK
dc.identifier.issue1en_HK
dc.identifier.spage113en_HK
dc.identifier.epage123en_HK
dc.identifier.isiWOS:A1997WE50100011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMo, R=7004448804en_HK
dc.identifier.scopusauthoridFreer, AM=36796301800en_HK
dc.identifier.scopusauthoridZinyk, DL=6508166040en_HK
dc.identifier.scopusauthoridCrackower, MA=6701530321en_HK
dc.identifier.scopusauthoridMichaud, J=7101819879en_HK
dc.identifier.scopusauthoridHeng, HHQ=7005338076en_HK
dc.identifier.scopusauthoridChik, KW=35580472400en_HK
dc.identifier.scopusauthoridShi, XM=7402953863en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridCheng, SH=7404684691en_HK
dc.identifier.scopusauthoridJoyner, AL=7006333684en_HK
dc.identifier.scopusauthoridHui, CC=7202876913en_HK

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