File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Renal function and renotropic effects of secretin in cystic fibrosis.

TitleRenal function and renotropic effects of secretin in cystic fibrosis.
Authors
Issue Date1997
PublisherHolzapfel Verlag GmbH.
Citation
European Journal Of Medical Research, 1997, v. 2 n. 10, p. 431-436 How to Cite?
AbstractIn ten cystic fibrosis patients and nine age-matched controls, renal function was determined before and after infusion of secretin. Under baseline conditions creatinine excretion and clearance were significantly elevated, exclusively due to those patients who were homozygous for the DF508 mutation (153 vs 132 ml/min*1.73m2), whereas the glomerular filtration rate, measured by inulin clearance showed no difference. Renal plasma flow and the fractional reabsorption rates of electrolytes were similar in patients and controls. During secretin infusion renal plasma flow increased and the fractional reabsorption rates of electrolytes decreased in both groups. The patients had a increased metabolic clearance (2900 vs 1660 ml/min*m2) and endogenous production rate (9,9 vs 2,5 pmol/min*m2) of of secretin. In conclusion global renal function and electrolyte handling, in particular chloride permeability, are unchanged in cystic fibrosis. Individuals expressing the DF508 genotype showed a selective elevation of creatinine excretion and clearance. The secretion and metabolic clearance of secretin are increased in cystic fibrosis.
Persistent Identifierhttp://hdl.handle.net/10722/133917
ISSN
2015 Impact Factor: 1.684
2015 SCImago Journal Rankings: 0.592

 

DC FieldValueLanguage
dc.contributor.authorWindstetter, Den_HK
dc.contributor.authorSchaefer, Fen_HK
dc.contributor.authorSchärer, Ken_HK
dc.contributor.authorReiter, Ken_HK
dc.contributor.authorEife, Ren_HK
dc.contributor.authorHarms, HKen_HK
dc.contributor.authorBerteleHarms, Ren_HK
dc.contributor.authorFiedler, Fen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorReitmeir, Pen_HK
dc.contributor.authorHorster, Men_HK
dc.contributor.authorHadorn, HBen_HK
dc.date.accessioned2011-06-07T03:25:38Z-
dc.date.available2011-06-07T03:25:38Z-
dc.date.issued1997en_HK
dc.identifier.citationEuropean Journal Of Medical Research, 1997, v. 2 n. 10, p. 431-436en_HK
dc.identifier.issn0949-2321en_HK
dc.identifier.urihttp://hdl.handle.net/10722/133917-
dc.description.abstractIn ten cystic fibrosis patients and nine age-matched controls, renal function was determined before and after infusion of secretin. Under baseline conditions creatinine excretion and clearance were significantly elevated, exclusively due to those patients who were homozygous for the DF508 mutation (153 vs 132 ml/min*1.73m2), whereas the glomerular filtration rate, measured by inulin clearance showed no difference. Renal plasma flow and the fractional reabsorption rates of electrolytes were similar in patients and controls. During secretin infusion renal plasma flow increased and the fractional reabsorption rates of electrolytes decreased in both groups. The patients had a increased metabolic clearance (2900 vs 1660 ml/min*m2) and endogenous production rate (9,9 vs 2,5 pmol/min*m2) of of secretin. In conclusion global renal function and electrolyte handling, in particular chloride permeability, are unchanged in cystic fibrosis. Individuals expressing the DF508 genotype showed a selective elevation of creatinine excretion and clearance. The secretion and metabolic clearance of secretin are increased in cystic fibrosis.en_HK
dc.languageeng-
dc.publisherHolzapfel Verlag GmbH.-
dc.relation.ispartofEuropean journal of medical researchen_HK
dc.subject.meshCystic Fibrosis - genetics - physiopathology-
dc.subject.meshElectrolytes - metabolism-
dc.subject.meshKidney - drug effects - physiopathology-
dc.subject.meshRenal Plasma Flow - drug effects-
dc.subject.meshSecretin - administration and dosage - diagnostic use - physiology-
dc.titleRenal function and renotropic effects of secretin in cystic fibrosis.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0949-2321&volume=2&issue=10&spage=431&epage=436&date=1997&atitle=Renal+function+and+renotropic+effects+of+secretin+in+cystic+fibrosis-
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9348270-
dc.identifier.scopuseid_2-s2.0-0031591940en_HK
dc.identifier.hkuros121070-
dc.identifier.volume2en_HK
dc.identifier.issue10en_HK
dc.identifier.spage431en_HK
dc.identifier.epage436en_HK
dc.identifier.scopusauthoridWindstetter, D=36839397000en_HK
dc.identifier.scopusauthoridSchaefer, F=7103383884en_HK
dc.identifier.scopusauthoridSchärer, K=7101998734en_HK
dc.identifier.scopusauthoridReiter, K=7006735445en_HK
dc.identifier.scopusauthoridEife, R=7004137708en_HK
dc.identifier.scopusauthoridHarms, HK=7103319049en_HK
dc.identifier.scopusauthoridBerteleHarms, R=6602823539en_HK
dc.identifier.scopusauthoridFiedler, F=7103026114en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridReitmeir, P=6701599480en_HK
dc.identifier.scopusauthoridHorster, M=7006948694en_HK
dc.identifier.scopusauthoridHadorn, HB=6701786387en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats