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Article: Identification of a 1300 kilobase deletion unit on chromosome 7q31.3 in invasive epithelial ovarian carcinomas

TitleIdentification of a 1300 kilobase deletion unit on chromosome 7q31.3 in invasive epithelial ovarian carcinomas
Authors
KeywordsBorderline
Cancer
Chromosome 7
LOH
Ovary
Issue Date1997
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/onc
Citation
Oncogene, 1997, v. 14 n. 24, p. 2979-2984 How to Cite?
AbstractWe have used polymerase chain reaction (PCR) amplification of tandem repeats to study the pattern of allelic loss on chromosome 7q31 in invasive epithelial ovarian carcinomas and borderline ovarian tumors. Using 13 primer sets spanning loci from 7q31 to 7q32, 16 borderline and 54 invasive ovarian tumor tissue, together with their corresponding normal tissue, were analysed. Invasive epithelial ovarian tumors demonstrated loss of heterozygosity (LOH) at one or more loci on 7q in 32 of 54 cases (59%). The invasive epithelial ovarian tumors demonstrated the highest percentage of LOH at the loci D7S643 (20 of 40 informative cases, 50%) and GATA44F09 (18 of 42 informative cases, 43%). In contrary, only one borderline ovarian tumor showed LOH at one locus (GATA44F09, one of 14 informative cases, 7%). Our results display a sharp contrast in the pattern of LOH between invasive and borderline ovarian tumors suggesting that allelic loss at chromosome 7q31.3 may be involved in the development and progression of invasive epithelial ovarian tumors but not borderline ovarian tumors. Further analysis of the deletion map for the invasive epithelial ovarian tumors showed two regions likely to harbor ovarian tumor suppressor genes including a novel 1300 kilobase common loss region flanked by GATA44F09 and D7S643.
Persistent Identifierhttp://hdl.handle.net/10722/133884
ISSN
2015 Impact Factor: 7.932
2015 SCImago Journal Rankings: 4.047
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorEdelson, MIen_HK
dc.contributor.authorScherer, SWen_HK
dc.contributor.authorTsui, LCen_HK
dc.contributor.authorWelch, WRen_HK
dc.contributor.authorBell, DAen_HK
dc.contributor.authorBerkowitz, RSen_HK
dc.contributor.authorMok, SCen_HK
dc.date.accessioned2011-06-03T04:27:25Z-
dc.date.available2011-06-03T04:27:25Z-
dc.date.issued1997en_HK
dc.identifier.citationOncogene, 1997, v. 14 n. 24, p. 2979-2984en_HK
dc.identifier.issn0950-9232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/133884-
dc.description.abstractWe have used polymerase chain reaction (PCR) amplification of tandem repeats to study the pattern of allelic loss on chromosome 7q31 in invasive epithelial ovarian carcinomas and borderline ovarian tumors. Using 13 primer sets spanning loci from 7q31 to 7q32, 16 borderline and 54 invasive ovarian tumor tissue, together with their corresponding normal tissue, were analysed. Invasive epithelial ovarian tumors demonstrated loss of heterozygosity (LOH) at one or more loci on 7q in 32 of 54 cases (59%). The invasive epithelial ovarian tumors demonstrated the highest percentage of LOH at the loci D7S643 (20 of 40 informative cases, 50%) and GATA44F09 (18 of 42 informative cases, 43%). In contrary, only one borderline ovarian tumor showed LOH at one locus (GATA44F09, one of 14 informative cases, 7%). Our results display a sharp contrast in the pattern of LOH between invasive and borderline ovarian tumors suggesting that allelic loss at chromosome 7q31.3 may be involved in the development and progression of invasive epithelial ovarian tumors but not borderline ovarian tumors. Further analysis of the deletion map for the invasive epithelial ovarian tumors showed two regions likely to harbor ovarian tumor suppressor genes including a novel 1300 kilobase common loss region flanked by GATA44F09 and D7S643.en_HK
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/oncen_HK
dc.relation.ispartofOncogeneen_HK
dc.subjectBorderlineen_HK
dc.subjectCanceren_HK
dc.subjectChromosome 7en_HK
dc.subjectLOHen_HK
dc.subjectOvaryen_HK
dc.subject.meshChromosome Mapping-
dc.subject.meshChromosomes, Human, Pair 7-
dc.subject.meshDNA, Neoplasm - genetics-
dc.subject.meshEpithelium - pathology-
dc.subject.meshOvarian Neoplasms - genetics - pathology-
dc.titleIdentification of a 1300 kilobase deletion unit on chromosome 7q31.3 in invasive epithelial ovarian carcinomasen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0950-9232&volume=14&issue=24&spage=2979&epage=2984&date=1997&atitle=Identification+of+a+1300+kilobase+deletion+unit+on+chromosome+7q31.3+in+invasive+epithelial+ovarian+carcinomas-
dc.identifier.emailTsui, LC: tsuilc@hkucc.hku.hken_HK
dc.identifier.authorityTsui, LC=rp00058en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/sj.onc.1201271en_HK
dc.identifier.pmid9205105-
dc.identifier.scopuseid_2-s2.0-0030792170en_HK
dc.identifier.hkuros121054-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030792170&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue24en_HK
dc.identifier.spage2979en_HK
dc.identifier.epage2984en_HK
dc.identifier.isiWOS:A1997XF55500012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridEdelson, MI=7003756000en_HK
dc.identifier.scopusauthoridScherer, SW=35374654500en_HK
dc.identifier.scopusauthoridTsui, LC=7102754167en_HK
dc.identifier.scopusauthoridWelch, WR=35265514400en_HK
dc.identifier.scopusauthoridBell, DA=7403648185en_HK
dc.identifier.scopusauthoridBerkowitz, RS=7201352221en_HK
dc.identifier.scopusauthoridMok, SC=7006015487en_HK

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