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Article: Lectins: production and practical applications

TitleLectins: production and practical applications
Authors
Issue Date2011
PublisherSpringer. The Journal's web site is located at http://link.springer.de/link/service/journals/00253/index.htm
Citation
Applied microbiology and biotechnology, 2011, v. 89 n. 1, p. 45-55 How to Cite?
AbstractLectins are proteins found in a diversity of organisms. They possess the ability to agglutinate erythrocytes with known carbohydrate specificity since they have at least one non-catalytic domain that binds reversibly to specific monosaccharides or oligosaccharides. This articles aims to review the production and practical applications of lectins. Lectins are isolated from their natural sources by chromatographic procedures or produced by recombinant DNA technology. The yields of animal lectins are usually low compared with the yields of plant lectins such as legume lectins. Lectins manifest a diversity of activities including antitumor, immunomodulatory, antifungal, HIV-1 reverse transcriptase inhibitory, and anti-insect activities, which may find practical applications. A small number of lectins demonstrate antibacterial and anti-nematode activities.
Persistent Identifierhttp://hdl.handle.net/10722/133818
ISSN
2015 Impact Factor: 3.376
2015 SCImago Journal Rankings: 1.262
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Medicine Panel, CUHK Research Committee
Funding Information:

The award of a direct grant by the Medicine Panel, CUHK Research Committee is gratefully acknowledged.

 

DC FieldValueLanguage
dc.contributor.authorLam, SKen_US
dc.contributor.authorNg, TBen_US
dc.date.accessioned2011-05-31T07:09:44Z-
dc.date.available2011-05-31T07:09:44Z-
dc.date.issued2011en_US
dc.identifier.citationApplied microbiology and biotechnology, 2011, v. 89 n. 1, p. 45-55-
dc.identifier.issn0175-7598en_US
dc.identifier.urihttp://hdl.handle.net/10722/133818-
dc.description.abstractLectins are proteins found in a diversity of organisms. They possess the ability to agglutinate erythrocytes with known carbohydrate specificity since they have at least one non-catalytic domain that binds reversibly to specific monosaccharides or oligosaccharides. This articles aims to review the production and practical applications of lectins. Lectins are isolated from their natural sources by chromatographic procedures or produced by recombinant DNA technology. The yields of animal lectins are usually low compared with the yields of plant lectins such as legume lectins. Lectins manifest a diversity of activities including antitumor, immunomodulatory, antifungal, HIV-1 reverse transcriptase inhibitory, and anti-insect activities, which may find practical applications. A small number of lectins demonstrate antibacterial and anti-nematode activities.en_US
dc.languageengen_US
dc.publisherSpringer. The Journal's web site is located at http://link.springer.de/link/service/journals/00253/index.htmen_US
dc.relation.ispartofApplied microbiology and biotechnologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThe original publication is available at www.springerlink.comen_US
dc.subject.meshAnimals-
dc.subject.meshAquatic Organisms - genetics - metabolism-
dc.subject.meshLectins - genetics - isolation and purification - metabolism - pharmacology-
dc.subject.meshPlants - genetics - metabolism-
dc.subject.meshRecombinant Proteins - genetics - isolation and purification - metabolism - pharmacology-
dc.titleLectins: production and practical applicationsen_US
dc.typeArticleen_US
dc.identifier.emailLam, SK: sklam77@hku.hk; lamszekwan@yahoo.com.hk-
dc.identifier.emailNg, TB: b021770@mailserv.cuhk.edu.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1007/s00253-010-2892-9en_US
dc.identifier.pmid20890754-
dc.identifier.pmcidPMC3016214-
dc.identifier.scopuseid_2-s2.0-78651077844en_US
dc.identifier.hkuros188449en_US
dc.identifier.volume89en_US
dc.identifier.issue1en_US
dc.identifier.spage45en_US
dc.identifier.epage55en_US
dc.identifier.eissn1432-0614en_US
dc.identifier.isiWOS:000285884200005-
dc.publisher.placeGermany-
dc.description.otherSpringer Open Choice, 31 May 2011en_US
dc.identifier.citeulike7970135-

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