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Article: Activity levels in the left hemisphere caudate-fusiform circuit predict how well a second language will be learned

TitleActivity levels in the left hemisphere caudate-fusiform circuit predict how well a second language will be learned
Authors
KeywordsBasal ganglia
Biomarker
Extrastriate cortex
Visual system
Issue Date2011
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2011, v. 108 n. 6, p. 2540-2544 How to Cite?
AbstractHow second language (L2) learning is achieved in the human brain remains one of the fundamental questions of neuroscience and linguistics. Previous neuroimaging studies with bilinguals have consistently shown overlapping cortical organization of the native language (L1) and L2, leading to a prediction that a common neurobiological marker may be responsible for the development of the two languages. Here, by using functional MRI, we show that later skills to read in L2 are predicted by the activity level of the fusiform-caudate circuit in the left hemisphere, which nonetheless is not predictive of the ability to read in the native language. We scanned 10-y-old children while they performed a lexical decision task on L2 (and L1) stimuli. The subjects' written language (reading) skills were behaviorally assessed twice, the first time just before we performed the fMRI scan (time 1 reading) and the second time 1 y later (time 2 reading). A whole-brain based analysis revealed that activity levels in left caudate and left fusiform gyrus correlated with L2 literacy skills at time 1. After controlling for the effects of time 1 reading and nonverbal IQ, or the effect of in-scanner lexical performance, the development in L2 literacy skills (time 2 reading) was also predicted by activity in left caudate and fusiform regions that are thought to mediate language control functions and resolve competition arising from L1 during L2 learning. Our findings suggest that the activity level of left caudate and fusiform regions serves as an important neurobiological marker for predicting accomplishment in reading skills in a new language.
Persistent Identifierhttp://hdl.handle.net/10722/133746
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Ministry of Science and Technology of China2005CB522802
National Natural Science Foundation of China30621004
Research Grants Council of the Hong Kong Government775709M
University of Hong Kong
Funding Information:

We thank Stephen Matthews, John Spinks, and Paul Tam for constructive comments and Yan Cao, Daojing Dong, Ming Gao, Yan Ha, Junping Yang, Ke Zhou, and Yan Zhuo for help with the experiments. This research was supported by grants from the national strategic basic research program of the Ministry of Science and Technology of China ("973" project 2005CB522802), the National Natural Science Foundation of China (Grant 30621004), the Research Grants Council of the Hong Kong Government (775709M), and the University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorTan, LHen_HK
dc.contributor.authorChen, Len_HK
dc.contributor.authorYip, Ven_HK
dc.contributor.authorChan, AHDen_HK
dc.contributor.authorYang, Jen_HK
dc.contributor.authorGao, JHen_HK
dc.contributor.authorSiok, WTen_HK
dc.date.accessioned2011-05-24T02:17:50Z-
dc.date.available2011-05-24T02:17:50Z-
dc.date.issued2011en_HK
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2011, v. 108 n. 6, p. 2540-2544en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/133746-
dc.description.abstractHow second language (L2) learning is achieved in the human brain remains one of the fundamental questions of neuroscience and linguistics. Previous neuroimaging studies with bilinguals have consistently shown overlapping cortical organization of the native language (L1) and L2, leading to a prediction that a common neurobiological marker may be responsible for the development of the two languages. Here, by using functional MRI, we show that later skills to read in L2 are predicted by the activity level of the fusiform-caudate circuit in the left hemisphere, which nonetheless is not predictive of the ability to read in the native language. We scanned 10-y-old children while they performed a lexical decision task on L2 (and L1) stimuli. The subjects' written language (reading) skills were behaviorally assessed twice, the first time just before we performed the fMRI scan (time 1 reading) and the second time 1 y later (time 2 reading). A whole-brain based analysis revealed that activity levels in left caudate and left fusiform gyrus correlated with L2 literacy skills at time 1. After controlling for the effects of time 1 reading and nonverbal IQ, or the effect of in-scanner lexical performance, the development in L2 literacy skills (time 2 reading) was also predicted by activity in left caudate and fusiform regions that are thought to mediate language control functions and resolve competition arising from L1 during L2 learning. Our findings suggest that the activity level of left caudate and fusiform regions serves as an important neurobiological marker for predicting accomplishment in reading skills in a new language.en_HK
dc.languageengen_US
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_HK
dc.subjectBasal gangliaen_HK
dc.subjectBiomarkeren_HK
dc.subjectExtrastriate cortexen_HK
dc.subjectVisual systemen_HK
dc.subject.meshBrain Mapping-
dc.subject.meshCerebral Cortex - physiology-
dc.subject.meshMultilingualism-
dc.subject.meshReading-
dc.subject.meshVerbal Learning - physiology-
dc.titleActivity levels in the left hemisphere caudate-fusiform circuit predict how well a second language will be learneden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0027-8424&volume=108&issue=6&spage=2540–2544&epage=&date=2011&atitle=Activity+levels+in+the+left+hemisphere+caudate-fusiform+circuit+predict+how+well+a+second+language+will+be+learned-
dc.identifier.emailTan, LH: tanlh@hku.hken_HK
dc.identifier.emailSiok, WT: siok@hkucc.hku.hken_HK
dc.identifier.authorityTan, LH=rp01202en_HK
dc.identifier.authoritySiok, WT=rp01208en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1073/pnas.0909623108en_HK
dc.identifier.pmid21262807-
dc.identifier.pmcidPMC3038767-
dc.identifier.scopuseid_2-s2.0-79952287687en_HK
dc.identifier.hkuros185157en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952287687&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume108en_HK
dc.identifier.issue6en_HK
dc.identifier.spage2540en_HK
dc.identifier.epage2544en_HK
dc.identifier.isiWOS:000287084500067-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTan, LH=7402233462en_HK
dc.identifier.scopusauthoridChen, L=35279358200en_HK
dc.identifier.scopusauthoridYip, V=16246810500en_HK
dc.identifier.scopusauthoridChan, AHD=23766960600en_HK
dc.identifier.scopusauthoridYang, J=41862756700en_HK
dc.identifier.scopusauthoridGao, JH=7404475674en_HK
dc.identifier.scopusauthoridSiok, WT=6602471035en_HK
dc.identifier.citeulike8815598-

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