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Article: Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques

TitleEpithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques
Authors
Issue Date2011
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2011, v. 85 n. 8, p. 4025-4030 How to Cite?
AbstractThe shedding of severe acute respiratory syndrome coronavirus (SARS-CoV) into saliva droplets plays a critical role in viral transmission. The source of high viral loads in saliva, however, remains elusive. Here we investigate the early target cells of infection in the entire array of respiratory tissues in Chinese macaques after intranasal inoculations with a single-cycle pseudotyped virus and a pathogenic SARS-CoV. We found that angiotensin-converting enzyme 2-positive (ACE2 +) cells were widely distributed in the upper respiratory tract, and ACE2 + epithelial cells lining salivary gland ducts were the early target cells productively infected. Our findings also have implications for SARS-CoV early diagnosis and prevention. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/133663
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
U.S. National Heart, Lung and Blood InstituteRO1 HL080211-02
TNPRCRR00164
University of Hong Kong
Funding Information:

We also thank the U.S. National Heart, Lung and Blood Institute (RO1 HL080211-02 to Z.C.), the TNPRC base grant RR00164, and the UDF/LKS grants of the University of Hong Kong to its AIDS Institute for financial support.

References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Len_HK
dc.contributor.authorWei, Qen_HK
dc.contributor.authorAlvarez, Xen_HK
dc.contributor.authorWang, Hen_HK
dc.contributor.authorDu, Yen_HK
dc.contributor.authorZhu, Hen_HK
dc.contributor.authorJiang, Hen_HK
dc.contributor.authorZhou, Jen_HK
dc.contributor.authorLam, Pen_HK
dc.contributor.authorZhang, Len_HK
dc.contributor.authorLackner, Aen_HK
dc.contributor.authorQin, Cen_HK
dc.contributor.authorChen, Zen_HK
dc.date.accessioned2011-05-24T02:14:05Z-
dc.date.available2011-05-24T02:14:05Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Virology, 2011, v. 85 n. 8, p. 4025-4030en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/133663-
dc.description.abstractThe shedding of severe acute respiratory syndrome coronavirus (SARS-CoV) into saliva droplets plays a critical role in viral transmission. The source of high viral loads in saliva, however, remains elusive. Here we investigate the early target cells of infection in the entire array of respiratory tissues in Chinese macaques after intranasal inoculations with a single-cycle pseudotyped virus and a pathogenic SARS-CoV. We found that angiotensin-converting enzyme 2-positive (ACE2 +) cells were widely distributed in the upper respiratory tract, and ACE2 + epithelial cells lining salivary gland ducts were the early target cells productively infected. Our findings also have implications for SARS-CoV early diagnosis and prevention. Copyright © 2011, American Society for Microbiology. All Rights Reserved.en_HK
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.-
dc.rightsCopyright © American Society for Microbiology,Journal of Virology, 2011, v. 85 n. 8, p. 4025-4030-
dc.subject.meshEpithelial Cells - virology-
dc.subject.meshImmunohistochemistry-
dc.subject.meshSARS Virus - isolation and purification - pathogenicity-
dc.subject.meshSalivary Ducts - virology-
dc.subject.meshSevere Acute Respiratory Syndrome - veterinary - virology-
dc.titleEpithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaquesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=85&issue=8&spage=4025&epage=4030&date=2011&atitle=Epithelial+cells+lining+salivary+gland+ducts+are+early+target+cells+of+severe+acute+respiratory+syndrome+coronavirus+infection+in+the+upper+respiratory+tract+of+rhesus+macaques-
dc.identifier.emailLiu, L: liuli71@hkucc.hku.hken_HK
dc.identifier.emailWang, H: haibo@hku.hken_HK
dc.identifier.emailChen, Z: zchenai@hku.hken_HK
dc.identifier.authorityLiu, L=rp00268en_HK
dc.identifier.authorityWang, H=rp00279en_HK
dc.identifier.authorityChen, Z=rp00243en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1128/JVI.02292-10en_HK
dc.identifier.pmid21289121-
dc.identifier.pmcidPMC3126125-
dc.identifier.scopuseid_2-s2.0-79952831478en_HK
dc.identifier.hkuros185273en_US
dc.identifier.hkuros206297en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952831478&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume85en_HK
dc.identifier.issue8en_HK
dc.identifier.spage4025en_HK
dc.identifier.epage4030en_HK
dc.identifier.eissn1098-5514-
dc.identifier.isiWOS:000288536100031-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, L=35784425200en_HK
dc.identifier.scopusauthoridWei, Q=7201692917en_HK
dc.identifier.scopusauthoridAlvarez, X=7005973195en_HK
dc.identifier.scopusauthoridWang, H=36143443600en_HK
dc.identifier.scopusauthoridDu, Y=37033670700en_HK
dc.identifier.scopusauthoridZhu, H=35070757700en_HK
dc.identifier.scopusauthoridJiang, H=36077295400en_HK
dc.identifier.scopusauthoridZhou, J=36143448600en_HK
dc.identifier.scopusauthoridLam, P=44761265800en_HK
dc.identifier.scopusauthoridZhang, L=35274165900en_HK
dc.identifier.scopusauthoridLackner, A=7004326651en_HK
dc.identifier.scopusauthoridQin, C=7102688076en_HK
dc.identifier.scopusauthoridChen, Z=35271180800en_HK

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