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Article: Identification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027

TitleIdentification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027
Authors
KeywordsBiosynthesis
Enediynes
Enzyme catalysis
Natural products
Polyketides
Issue Date2010
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
Citation
Angewandte Chemie - International Edition, 2010, v. 49 n. 43, p. 7926-7928 How to Cite?
AbstractNot octa- but nonaketide: The nine-membered enediyne core polyketide synthase SgcE efficiently synthesizes a nonaketide in the absence of any assisting proteins (see scheme), contrary to the suggestion that an octaketide is the product of the synthase under assistance from a thioesterase. This finding redefines the catalytic functions of the polyketide synthase. CoA=coenzyme A. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/133604
ISSN
2014 Impact Factor: 11.261
2014 SCImago Journal Rankings: 5.149
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of the HKSAR governmentRPC10SC07
Funding Information:

We thank the Research Grants Council of the HKSAR government for financial support (RPC10SC07).

References

 

DC FieldValueLanguage
dc.contributor.authorChen, Xen_HK
dc.contributor.authorGuo, ZFen_HK
dc.contributor.authorLai, PMen_HK
dc.contributor.authorSze, KHen_HK
dc.contributor.authorGuo, Zen_HK
dc.date.accessioned2011-05-24T02:11:38Z-
dc.date.available2011-05-24T02:11:38Z-
dc.date.issued2010en_HK
dc.identifier.citationAngewandte Chemie - International Edition, 2010, v. 49 n. 43, p. 7926-7928en_HK
dc.identifier.issn1433-7851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/133604-
dc.description.abstractNot octa- but nonaketide: The nine-membered enediyne core polyketide synthase SgcE efficiently synthesizes a nonaketide in the absence of any assisting proteins (see scheme), contrary to the suggestion that an octaketide is the product of the synthase under assistance from a thioesterase. This finding redefines the catalytic functions of the polyketide synthase. CoA=coenzyme A. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_HK
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/homeen_HK
dc.relation.ispartofAngewandte Chemie - International Editionen_HK
dc.subjectBiosynthesisen_HK
dc.subjectEnediynesen_HK
dc.subjectEnzyme catalysisen_HK
dc.subjectNatural productsen_HK
dc.subjectPolyketidesen_HK
dc.subject.meshAminoglycosides - metabolism-
dc.subject.meshAntibiotics, Antineoplastic - metabolism-
dc.subject.meshBacterial Proteins - genetics - metabolism-
dc.subject.meshEnediynes - metabolism-
dc.subject.meshPolyketide Synthases - genetics - metabolism-
dc.titleIdentification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1433-7851&volume=49&issue=43&spage=7926&epage=7928&date=2010&atitle=Identification+of+a+nonaketide+product+for+the+iterative+polyketide+synthase+in+biosynthesis+of+the+nine-membered+enediyne+C-1027-
dc.identifier.emailSze, KH:khsze@hku.hken_HK
dc.identifier.authoritySze, KH=rp00785en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/anie.201003369en_HK
dc.identifier.pmid20848627-
dc.identifier.scopuseid_2-s2.0-78349264615en_HK
dc.identifier.hkuros185366en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78349264615&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue43en_HK
dc.identifier.spage7926en_HK
dc.identifier.epage7928en_HK
dc.identifier.eissn1521-3773-
dc.identifier.isiWOS:000283818600016-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridChen, X=21933863800en_HK
dc.identifier.scopusauthoridGuo, ZF=8293395500en_HK
dc.identifier.scopusauthoridLai, PM=37034286300en_HK
dc.identifier.scopusauthoridSze, KH=7006735061en_HK
dc.identifier.scopusauthoridGuo, Z=7404658303en_HK

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