Article: Identification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027

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TitleIdentification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027
AuthorsChen, X2
Guo, ZF2
Lai, PM1
Sze, KH1
Guo, Z2
KeywordsBiosynthesis
Enediynes
Enzyme catalysis
Natural products
Polyketides
Issue Date2010
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
CitationAngewandte Chemie - International Edition, 2010, v. 49 n. 43, p. 7926-7928 [How to Cite?]
DOI: http://dx.doi.org/10.1002/anie.201003369
AbstractNot octa- but nonaketide: The nine-membered enediyne core polyketide synthase SgcE efficiently synthesizes a nonaketide in the absence of any assisting proteins (see scheme), contrary to the suggestion that an octaketide is the product of the synthase under assistance from a thioesterase. This finding redefines the catalytic functions of the polyketide synthase. CoA=coenzyme A. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISSN1433-7851
2011 Impact Factor: 13.455
DOIhttp://dx.doi.org/10.1002/anie.201003369
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChen, X
dc.contributor.authorGuo, ZF
dc.contributor.authorLai, PM
dc.contributor.authorSze, KH
dc.contributor.authorGuo, Z
dc.date.accessioned2011-05-24T02:11:38Z
dc.date.available2011-05-24T02:11:38Z
dc.date.issued2010
dc.description.abstractNot octa- but nonaketide: The nine-membered enediyne core polyketide synthase SgcE efficiently synthesizes a nonaketide in the absence of any assisting proteins (see scheme), contrary to the suggestion that an octaketide is the product of the synthase under assistance from a thioesterase. This finding redefines the catalytic functions of the polyketide synthase. CoA=coenzyme A. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAngewandte Chemie - International Edition, 2010, v. 49 n. 43, p. 7926-7928 [How to Cite?]
DOI: http://dx.doi.org/10.1002/anie.201003369
dc.identifier.doihttp://dx.doi.org/10.1002/anie.201003369
dc.identifier.epage7928
dc.identifier.hkuros185366
dc.identifier.isiWOS:000283818600016
Funding AgencyGrant Number
Research Grants Council of the HKSAR governmentRPC10SC07
Funding Information:

We thank the Research Grants Council of the HKSAR government for financial support (RPC10SC07).

dc.identifier.issn1433-7851
2011 Impact Factor: 13.455
dc.identifier.issue43
dc.identifier.openurl
dc.identifier.pmid20848627
dc.identifier.scopuseid_2-s2.0-78349264615
dc.identifier.spage7926
dc.identifier.urihttp://hdl.handle.net/10722/133604
dc.identifier.volume49
dc.languageeng
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
dc.publisher.placeGermany
dc.relation.ispartofAngewandte Chemie - International Edition
dc.relation.referencesReferences in Scopus
dc.subject.meshAminoglycosides - metabolism
dc.subject.meshAntibiotics, Antineoplastic - metabolism
dc.subject.meshBacterial Proteins - genetics - metabolism
dc.subject.meshEnediynes - metabolism
dc.subject.meshPolyketide Synthases - genetics - metabolism
dc.subjectBiosynthesis
dc.subjectEnediynes
dc.subjectEnzyme catalysis
dc.subjectNatural products
dc.subjectPolyketides
dc.titleIdentification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Hong Kong University of Science and Technology