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Article: Identification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027
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TitleIdentification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027
 
AuthorsChen, X2
Guo, ZF2
Lai, PM1
Sze, KH1
Guo, Z2
 
KeywordsBiosynthesis
Enediynes
Enzyme catalysis
Natural products
Polyketides
 
Issue Date2010
 
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
 
CitationAngewandte Chemie - International Edition, 2010, v. 49 n. 43, p. 7926-7928 [How to Cite?]
DOI: http://dx.doi.org/10.1002/anie.201003369
 
AbstractNot octa- but nonaketide: The nine-membered enediyne core polyketide synthase SgcE efficiently synthesizes a nonaketide in the absence of any assisting proteins (see scheme), contrary to the suggestion that an octaketide is the product of the synthase under assistance from a thioesterase. This finding redefines the catalytic functions of the polyketide synthase. CoA=coenzyme A. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
 
ISSN1433-7851
2013 Impact Factor: 11.336
 
DOIhttp://dx.doi.org/10.1002/anie.201003369
 
ISI Accession Number IDWOS:000283818600016
Funding AgencyGrant Number
Research Grants Council of the HKSAR governmentRPC10SC07
Funding Information:

We thank the Research Grants Council of the HKSAR government for financial support (RPC10SC07).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChen, X
 
dc.contributor.authorGuo, ZF
 
dc.contributor.authorLai, PM
 
dc.contributor.authorSze, KH
 
dc.contributor.authorGuo, Z
 
dc.date.accessioned2011-05-24T02:11:38Z
 
dc.date.available2011-05-24T02:11:38Z
 
dc.date.issued2010
 
dc.description.abstractNot octa- but nonaketide: The nine-membered enediyne core polyketide synthase SgcE efficiently synthesizes a nonaketide in the absence of any assisting proteins (see scheme), contrary to the suggestion that an octaketide is the product of the synthase under assistance from a thioesterase. This finding redefines the catalytic functions of the polyketide synthase. CoA=coenzyme A. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationAngewandte Chemie - International Edition, 2010, v. 49 n. 43, p. 7926-7928 [How to Cite?]
DOI: http://dx.doi.org/10.1002/anie.201003369
 
dc.identifier.doihttp://dx.doi.org/10.1002/anie.201003369
 
dc.identifier.eissn1521-3773
 
dc.identifier.epage7928
 
dc.identifier.hkuros185366
 
dc.identifier.isiWOS:000283818600016
Funding AgencyGrant Number
Research Grants Council of the HKSAR governmentRPC10SC07
Funding Information:

We thank the Research Grants Council of the HKSAR government for financial support (RPC10SC07).

 
dc.identifier.issn1433-7851
2013 Impact Factor: 11.336
 
dc.identifier.issue43
 
dc.identifier.openurl
 
dc.identifier.pmid20848627
 
dc.identifier.scopuseid_2-s2.0-78349264615
 
dc.identifier.spage7926
 
dc.identifier.urihttp://hdl.handle.net/10722/133604
 
dc.identifier.volume49
 
dc.languageeng
 
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
 
dc.publisher.placeGermany
 
dc.relation.ispartofAngewandte Chemie - International Edition
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAminoglycosides - metabolism
 
dc.subject.meshAntibiotics, Antineoplastic - metabolism
 
dc.subject.meshBacterial Proteins - genetics - metabolism
 
dc.subject.meshEnediynes - metabolism
 
dc.subject.meshPolyketide Synthases - genetics - metabolism
 
dc.subjectBiosynthesis
 
dc.subjectEnediynes
 
dc.subjectEnzyme catalysis
 
dc.subjectNatural products
 
dc.subjectPolyketides
 
dc.titleIdentification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Hong Kong University of Science and Technology