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Article: Identification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027

TitleIdentification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027
Authors
KeywordsBiosynthesis
Enediynes
Enzyme catalysis
Natural products
Polyketides
Issue Date2010
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
Citation
Angewandte Chemie - International Edition, 2010, v. 49 n. 43, p. 7926-7928 How to Cite?
Abstract
Not octa- but nonaketide: The nine-membered enediyne core polyketide synthase SgcE efficiently synthesizes a nonaketide in the absence of any assisting proteins (see scheme), contrary to the suggestion that an octaketide is the product of the synthase under assistance from a thioesterase. This finding redefines the catalytic functions of the polyketide synthase. CoA=coenzyme A. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/133604
ISSN
2013 Impact Factor: 11.336
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of the HKSAR governmentRPC10SC07
Funding Information:

We thank the Research Grants Council of the HKSAR government for financial support (RPC10SC07).

References

 

Author Affiliations
  1. The University of Hong Kong
  2. Hong Kong University of Science and Technology
DC FieldValueLanguage
dc.contributor.authorChen, Xen_HK
dc.contributor.authorGuo, ZFen_HK
dc.contributor.authorLai, PMen_HK
dc.contributor.authorSze, KHen_HK
dc.contributor.authorGuo, Zen_HK
dc.date.accessioned2011-05-24T02:11:38Z-
dc.date.available2011-05-24T02:11:38Z-
dc.date.issued2010en_HK
dc.identifier.citationAngewandte Chemie - International Edition, 2010, v. 49 n. 43, p. 7926-7928en_HK
dc.identifier.issn1433-7851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/133604-
dc.description.abstractNot octa- but nonaketide: The nine-membered enediyne core polyketide synthase SgcE efficiently synthesizes a nonaketide in the absence of any assisting proteins (see scheme), contrary to the suggestion that an octaketide is the product of the synthase under assistance from a thioesterase. This finding redefines the catalytic functions of the polyketide synthase. CoA=coenzyme A. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_HK
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/homeen_HK
dc.relation.ispartofAngewandte Chemie - International Editionen_HK
dc.subjectBiosynthesisen_HK
dc.subjectEnediynesen_HK
dc.subjectEnzyme catalysisen_HK
dc.subjectNatural productsen_HK
dc.subjectPolyketidesen_HK
dc.subject.meshAminoglycosides - metabolism-
dc.subject.meshAntibiotics, Antineoplastic - metabolism-
dc.subject.meshBacterial Proteins - genetics - metabolism-
dc.subject.meshEnediynes - metabolism-
dc.subject.meshPolyketide Synthases - genetics - metabolism-
dc.titleIdentification of a nonaketide product for the iterative polyketide synthase in biosynthesis of the nine-membered enediyne C-1027en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1433-7851&volume=49&issue=43&spage=7926&epage=7928&date=2010&atitle=Identification+of+a+nonaketide+product+for+the+iterative+polyketide+synthase+in+biosynthesis+of+the+nine-membered+enediyne+C-1027-
dc.identifier.emailSze, KH:khsze@hku.hken_HK
dc.identifier.authoritySze, KH=rp00785en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/anie.201003369en_HK
dc.identifier.pmid20848627en_HK
dc.identifier.scopuseid_2-s2.0-78349264615en_HK
dc.identifier.hkuros185366en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78349264615&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue43en_HK
dc.identifier.spage7926en_HK
dc.identifier.epage7928en_HK
dc.identifier.eissn1521-3773-
dc.identifier.isiWOS:000283818600016-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridChen, X=21933863800en_HK
dc.identifier.scopusauthoridGuo, ZF=8293395500en_HK
dc.identifier.scopusauthoridLai, PM=37034286300en_HK
dc.identifier.scopusauthoridSze, KH=7006735061en_HK
dc.identifier.scopusauthoridGuo, Z=7404658303en_HK

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