File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Lycium barbarum L.: A neuroprotective drug for glaucoma
  • Basic View
  • Metadata View
  • XML View
TitleLycium barbarum L.: A neuroprotective drug for glaucoma
枸杞子-青光眼的神經保護劑
 
AuthorsCkiu, K1
Liang, YX1
Chang, RCC1
So, KF1
 
KeywordsGlaucoma
Lycium barbarum l
Neuroprotective drug
 
Issue Date2011
 
PublisherBeijing Institute of Ophthalmology (北京市眼科硏究所). The Journal's web site is located at http://yk.periodicals.net.cn/
 
CitationOphthalmology In China, 2011, v. 20 n. 1, p. 21-27
眼科, 2011, v. 20 n. 1, p. 21-27 [How to Cite?]
 
AbstractThe active components in L. barbarum (wolfberry) include polysaccharide (LBP), zeaxanthin, beta-carotene, betaine, flavonoids, etc. The biological activities of L. barbarům can be summarized into two aspects. The first one is the intercellular effects on neurons. L. barbarum has immune modulation effects and it can activate microglia to an appropriate state (moderately activated) to protect retinal ganglion cells (RGCs) against ocular hypertension in glaucoma. It also suppresses the up-regulated GFAP immunoreactivity in the ocular hypertension retinas. The second aspect is the intracellular effects on neurons. L. barbarum is able to modulate a number of intracellular signaling pathways to reduce different pathological damages. It modulates both survival and pro-apoptotic pathways to maintain homeostatsis of our body under stress conditions. AU these lines of evidence suggest that L. barbarum utilizes multiple mechanisms for its protective effects on neurons. The ability of L. barbarum to interfere these pathways may explain why it can provide a broad-spectrum of protection, and this is the holistic approach of anti-aging herbs.
枸杞子的活性成份包括杞子多糖(LBP)、玉米黃質、β胡蘿卜素、甜菜堿、類黃酮等。枸杞子的生物效應至少包括兩方面:首先是對神經元的細胞間效應,枸杞子具有免疫調節作用,且可通過適度激活小膠質細胞而保護視網膜神經節細胞免受青光眼高眼壓的損害;它還可抑制高眼壓視網膜的GFAP免疫活性增高。其次是枸杞子對神經元的細胞內效應,它可調節多個細胞內途徑減低不同的病理損害。在應激情況下,它可通過調節細胞存活和凋亡通路來保持機體平衡。因此,枸杞子具有多種不同的神經保護機制,這也正是抗衰老中草藥的整體作用方式。
 
ISSN1004-4469
2013 SCImago Journal Rankings: 0.102
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCkiu, K
 
dc.contributor.authorLiang, YX
 
dc.contributor.authorChang, RCC
 
dc.contributor.authorSo, KF
 
dc.date.accessioned2011-05-24T02:11:03Z
 
dc.date.available2011-05-24T02:11:03Z
 
dc.date.issued2011
 
dc.description.abstractThe active components in L. barbarum (wolfberry) include polysaccharide (LBP), zeaxanthin, beta-carotene, betaine, flavonoids, etc. The biological activities of L. barbarům can be summarized into two aspects. The first one is the intercellular effects on neurons. L. barbarum has immune modulation effects and it can activate microglia to an appropriate state (moderately activated) to protect retinal ganglion cells (RGCs) against ocular hypertension in glaucoma. It also suppresses the up-regulated GFAP immunoreactivity in the ocular hypertension retinas. The second aspect is the intracellular effects on neurons. L. barbarum is able to modulate a number of intracellular signaling pathways to reduce different pathological damages. It modulates both survival and pro-apoptotic pathways to maintain homeostatsis of our body under stress conditions. AU these lines of evidence suggest that L. barbarum utilizes multiple mechanisms for its protective effects on neurons. The ability of L. barbarum to interfere these pathways may explain why it can provide a broad-spectrum of protection, and this is the holistic approach of anti-aging herbs.
 
dc.description.abstract枸杞子的活性成份包括杞子多糖(LBP)、玉米黃質、β胡蘿卜素、甜菜堿、類黃酮等。枸杞子的生物效應至少包括兩方面:首先是對神經元的細胞間效應,枸杞子具有免疫調節作用,且可通過適度激活小膠質細胞而保護視網膜神經節細胞免受青光眼高眼壓的損害;它還可抑制高眼壓視網膜的GFAP免疫活性增高。其次是枸杞子對神經元的細胞內效應,它可調節多個細胞內途徑減低不同的病理損害。在應激情況下,它可通過調節細胞存活和凋亡通路來保持機體平衡。因此,枸杞子具有多種不同的神經保護機制,這也正是抗衰老中草藥的整體作用方式。
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationOphthalmology In China, 2011, v. 20 n. 1, p. 21-27
 
dc.identifier.citation眼科, 2011, v. 20 n. 1, p. 21-27 [How to Cite?]
 
dc.identifier.epage27
 
dc.identifier.hkuros185091
 
dc.identifier.issn1004-4469
2013 SCImago Journal Rankings: 0.102
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.scopuseid_2-s2.0-79955786583
 
dc.identifier.spage21
 
dc.identifier.urihttp://hdl.handle.net/10722/133576
 
dc.identifier.volume20
 
dc.languagechi
 
dc.publisherBeijing Institute of Ophthalmology (北京市眼科硏究所). The Journal's web site is located at http://yk.periodicals.net.cn/
 
dc.publisher.placeBeijing (北京)
 
dc.relation.ispartofOphthalmology in China
 
dc.relation.ispartof眼科
 
dc.relation.referencesReferences in Scopus
 
dc.subjectGlaucoma
 
dc.subjectLycium barbarum l
 
dc.subjectNeuroprotective drug
 
dc.titleLycium barbarum L.: A neuroprotective drug for glaucoma
 
dc.title枸杞子-青光眼的神經保護劑
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Ckiu, K</contributor.author>
<contributor.author>Liang, YX</contributor.author>
<contributor.author>Chang, RCC</contributor.author>
<contributor.author>So, KF</contributor.author>
<date.accessioned>2011-05-24T02:11:03Z</date.accessioned>
<date.available>2011-05-24T02:11:03Z</date.available>
<date.issued>2011</date.issued>
<identifier.citation>Ophthalmology In China, 2011, v. 20 n. 1, p. 21-27</identifier.citation>
<identifier.citation>&#30524;&#31185;, 2011, v. 20 n. 1, p. 21-27</identifier.citation>
<identifier.issn>1004-4469</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/133576</identifier.uri>
<description.abstract>The active components in L. barbarum (wolfberry) include polysaccharide (LBP), zeaxanthin, beta-carotene, betaine, flavonoids, etc. The biological activities of L. barbar&#367;m can be summarized into two aspects. The first one is the intercellular effects on neurons. L. barbarum has immune modulation effects and it can activate microglia to an appropriate state (moderately activated) to protect retinal ganglion cells (RGCs) against ocular hypertension in glaucoma. It also suppresses the up-regulated GFAP immunoreactivity in the ocular hypertension retinas. The second aspect is the intracellular effects on neurons. L. barbarum is able to modulate a number of intracellular signaling pathways to reduce different pathological damages. It modulates both survival and pro-apoptotic pathways to maintain homeostatsis of our body under stress conditions. AU these lines of evidence suggest that L. barbarum utilizes multiple mechanisms for its protective effects on neurons. The ability of L. barbarum to interfere these pathways may explain why it can provide a broad-spectrum of protection, and this is the holistic approach of anti-aging herbs.</description.abstract>
<description.abstract>&#26552;&#26462;&#23376;&#30340;&#27963;&#24615;&#25104;&#20221;&#21253;&#25324;&#26462;&#23376;&#22810;&#31958;(LBP)&#12289;&#29577;&#31859;&#40643;&#36074;&#12289;&#946;&#32993;&#34367;&#21340;&#32032;&#12289;&#29980;&#33756;&#22591;&#12289;&#39006;&#40643;&#37230;&#31561;&#12290;&#26552;&#26462;&#23376;&#30340;&#29983;&#29289;&#25928;&#25033;&#33267;&#23569;&#21253;&#25324;&#20841;&#26041;&#38754;:&#39318;&#20808;&#26159;&#23565;&#31070;&#32147;&#20803;&#30340;&#32048;&#32990;&#38291;&#25928;&#25033;,&#26552;&#26462;&#23376;&#20855;&#26377;&#20813;&#30123;&#35519;&#31680;&#20316;&#29992;,&#19988;&#21487;&#36890;&#36942;&#36969;&#24230;&#28608;&#27963;&#23567;&#33184;&#36074;&#32048;&#32990;&#32780;&#20445;&#35703;&#35222;&#32178;&#33180;&#31070;&#32147;&#31680;&#32048;&#32990;&#20813;&#21463;&#38738;&#20809;&#30524;&#39640;&#30524;&#22739;&#30340;&#25613;&#23475;;&#23427;&#36996;&#21487;&#25233;&#21046;&#39640;&#30524;&#22739;&#35222;&#32178;&#33180;&#30340;GFAP&#20813;&#30123;&#27963;&#24615;&#22686;&#39640;&#12290;&#20854;&#27425;&#26159;&#26552;&#26462;&#23376;&#23565;&#31070;&#32147;&#20803;&#30340;&#32048;&#32990;&#20839;&#25928;&#25033;,&#23427;&#21487;&#35519;&#31680;&#22810;&#20491;&#32048;&#32990;&#20839;&#36884;&#24465;&#28187;&#20302;&#19981;&#21516;&#30340;&#30149;&#29702;&#25613;&#23475;&#12290;&#22312;&#25033;&#28608;&#24773;&#27841;&#19979;,&#23427;&#21487;&#36890;&#36942;&#35519;&#31680;&#32048;&#32990;&#23384;&#27963;&#21644;&#20939;&#20129;&#36890;&#36335;&#20358;&#20445;&#25345;&#27231;&#39636;&#24179;&#34913;&#12290;&#22240;&#27492;,&#26552;&#26462;&#23376;&#20855;&#26377;&#22810;&#31278;&#19981;&#21516;&#30340;&#31070;&#32147;&#20445;&#35703;&#27231;&#21046;,&#36889;&#20063;&#27491;&#26159;&#25239;&#34928;&#32769;&#20013;&#33609;&#34277;&#30340;&#25972;&#39636;&#20316;&#29992;&#26041;&#24335;&#12290;</description.abstract>
<language>chi</language>
<publisher>Beijing Institute of Ophthalmology (&#21271;&#20140;&#24066;&#30524;&#31185;&#30799;&#31350;&#25152;). The Journal&apos;s web site is located at http://yk.periodicals.net.cn/</publisher>
<relation.ispartof>Ophthalmology in China</relation.ispartof>
<relation.ispartof>&#30524;&#31185;</relation.ispartof>
<subject>Glaucoma</subject>
<subject>Lycium barbarum l</subject>
<subject>Neuroprotective drug</subject>
<title>Lycium barbarum L.: A neuroprotective drug for glaucoma</title>
<title>&#26552;&#26462;&#23376;-&#38738;&#20809;&#30524;&#30340;&#31070;&#32147;&#20445;&#35703;&#21137;</title>
<type>Article</type>
<identifier.openurl>http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=1004-4469&amp;volume=20&amp;issue=1&amp;spage=21&amp;epage=27&amp;date=2011&amp;atitle=Lycium+barbarum+L.:+a+neuroprotective+drug+for+glaucoma</identifier.openurl>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.scopus>eid_2-s2.0-79955786583</identifier.scopus>
<identifier.hkuros>185091</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-79955786583&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>20</identifier.volume>
<identifier.issue>1</identifier.issue>
<identifier.spage>21</identifier.spage>
<identifier.epage>27</identifier.epage>
<publisher.place>Beijing (&#21271;&#20140;)</publisher.place>
</item>
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine