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Article: Lycium barbarum L.: A neuroprotective drug for glaucoma

TitleLycium barbarum L.: A neuroprotective drug for glaucoma
枸杞子-青光眼的神經保護劑
Authors
KeywordsGlaucoma
Lycium barbarum l
Neuroprotective drug
Issue Date2011
PublisherBeijing Institute of Ophthalmology (北京市眼科硏究所). The Journal's web site is located at http://yk.periodicals.net.cn/
Citation
Ophthalmology In China, 2011, v. 20 n. 1, p. 21-27 How to Cite?
眼科, 2011, v. 20 n. 1, p. 21-27 How to Cite?
AbstractThe active components in L. barbarum (wolfberry) include polysaccharide (LBP), zeaxanthin, beta-carotene, betaine, flavonoids, etc. The biological activities of L. barbarům can be summarized into two aspects. The first one is the intercellular effects on neurons. L. barbarum has immune modulation effects and it can activate microglia to an appropriate state (moderately activated) to protect retinal ganglion cells (RGCs) against ocular hypertension in glaucoma. It also suppresses the up-regulated GFAP immunoreactivity in the ocular hypertension retinas. The second aspect is the intracellular effects on neurons. L. barbarum is able to modulate a number of intracellular signaling pathways to reduce different pathological damages. It modulates both survival and pro-apoptotic pathways to maintain homeostatsis of our body under stress conditions. AU these lines of evidence suggest that L. barbarum utilizes multiple mechanisms for its protective effects on neurons. The ability of L. barbarum to interfere these pathways may explain why it can provide a broad-spectrum of protection, and this is the holistic approach of anti-aging herbs.
枸杞子的活性成份包括杞子多糖(LBP)、玉米黃質、β胡蘿卜素、甜菜堿、類黃酮等。枸杞子的生物效應至少包括兩方面:首先是對神經元的細胞間效應,枸杞子具有免疫調節作用,且可通過適度激活小膠質細胞而保護視網膜神經節細胞免受青光眼高眼壓的損害;它還可抑制高眼壓視網膜的GFAP免疫活性增高。其次是枸杞子對神經元的細胞內效應,它可調節多個細胞內途徑減低不同的病理損害。在應激情況下,它可通過調節細胞存活和凋亡通路來保持機體平衡。因此,枸杞子具有多種不同的神經保護機制,這也正是抗衰老中草藥的整體作用方式。
Persistent Identifierhttp://hdl.handle.net/10722/133576
ISSN
2014 SCImago Journal Rankings: 0.100
References

 

DC FieldValueLanguage
dc.contributor.authorCkiu, Ken_HK
dc.contributor.authorLiang, YXen_HK
dc.contributor.authorChang, RCCen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2011-05-24T02:11:03Z-
dc.date.available2011-05-24T02:11:03Z-
dc.date.issued2011en_HK
dc.identifier.citationOphthalmology In China, 2011, v. 20 n. 1, p. 21-27en_HK
dc.identifier.citation眼科, 2011, v. 20 n. 1, p. 21-27-
dc.identifier.issn1004-4469en_HK
dc.identifier.urihttp://hdl.handle.net/10722/133576-
dc.description.abstractThe active components in L. barbarum (wolfberry) include polysaccharide (LBP), zeaxanthin, beta-carotene, betaine, flavonoids, etc. The biological activities of L. barbarům can be summarized into two aspects. The first one is the intercellular effects on neurons. L. barbarum has immune modulation effects and it can activate microglia to an appropriate state (moderately activated) to protect retinal ganglion cells (RGCs) against ocular hypertension in glaucoma. It also suppresses the up-regulated GFAP immunoreactivity in the ocular hypertension retinas. The second aspect is the intracellular effects on neurons. L. barbarum is able to modulate a number of intracellular signaling pathways to reduce different pathological damages. It modulates both survival and pro-apoptotic pathways to maintain homeostatsis of our body under stress conditions. AU these lines of evidence suggest that L. barbarum utilizes multiple mechanisms for its protective effects on neurons. The ability of L. barbarum to interfere these pathways may explain why it can provide a broad-spectrum of protection, and this is the holistic approach of anti-aging herbs.en_HK
dc.description.abstract枸杞子的活性成份包括杞子多糖(LBP)、玉米黃質、β胡蘿卜素、甜菜堿、類黃酮等。枸杞子的生物效應至少包括兩方面:首先是對神經元的細胞間效應,枸杞子具有免疫調節作用,且可通過適度激活小膠質細胞而保護視網膜神經節細胞免受青光眼高眼壓的損害;它還可抑制高眼壓視網膜的GFAP免疫活性增高。其次是枸杞子對神經元的細胞內效應,它可調節多個細胞內途徑減低不同的病理損害。在應激情況下,它可通過調節細胞存活和凋亡通路來保持機體平衡。因此,枸杞子具有多種不同的神經保護機制,這也正是抗衰老中草藥的整體作用方式。-
dc.languagechien_US
dc.publisherBeijing Institute of Ophthalmology (北京市眼科硏究所). The Journal's web site is located at http://yk.periodicals.net.cn/en_HK
dc.relation.ispartofOphthalmology in Chinaen_HK
dc.relation.ispartof眼科-
dc.subjectGlaucomaen_HK
dc.subjectLycium barbarum len_HK
dc.subjectNeuroprotective drugen_HK
dc.titleLycium barbarum L.: A neuroprotective drug for glaucomaen_HK
dc.title枸杞子-青光眼的神經保護劑-
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1004-4469&volume=20&issue=1&spage=21&epage=27&date=2011&atitle=Lycium+barbarum+L.:+a+neuroprotective+drug+for+glaucoma-
dc.identifier.emailLiang, YX: yxliang@hkucc.hku.hken_HK
dc.identifier.emailChang, RCC: rccchang@hku.hken_HK
dc.identifier.emailSo, KF: hrmaskf@hku.hken_HK
dc.identifier.authorityLiang, YX=rp00510en_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-79955786583en_HK
dc.identifier.hkuros185091en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955786583&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue1en_HK
dc.identifier.spage21en_HK
dc.identifier.epage27en_HK
dc.publisher.placeBeijing (北京)en_HK
dc.identifier.scopusauthoridCkiu, K=37121819300en_HK
dc.identifier.scopusauthoridLiang, YX=55479398500en_HK
dc.identifier.scopusauthoridChang, RCC=7403713410en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.customcontrol.immutablecsl 140618-

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