Article: Application of a Nano-antimicrobial film to prevent ventilator-associated pneumonia: A pilot study

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TitleApplication of a Nano-antimicrobial film to prevent ventilator-associated pneumonia: A pilot study
AuthorsLi, W1
Ma, X1
Peng, Y1
Cao, J1
Loo, WTY2 3
Hao, L4
Cheung, MNB3
Chow, LWC3
Jin, LJ2
KeywordsBacterial colonization
Nanotechnology antimicrobial spray
Oral care
Ventilator-associated pneumonia
Issue Date2011
PublisherAcademic Journals. The Journal's web site is located at http://www.academicjournals.org/AJB/index.htm
CitationAfrican Journal Of Biotechnology, 2011, v. 10 n. 10, p. 1926-1931 [How to Cite?]
AbstractVentilator-associated pneumonia (VAP) is one of the most common hospital-associated infections and has accounted for approximately 15% of all hospital-associated infections. In 76% of the VAP cases, the same bacteria colonize the oral cavity and lungs. Oral care interventions may play a role in the prevention of VAP, yet more than half of the hospitals do not have specific policies for the oral care of intubated patients. Oral cavity interlinks with respiratory tracts and digestive tracts. After surgery has been performed in these areas, aerobic and anaerobic bacteria frequently induce operative wound infections in teeth, gingiva and supporting tissues of the teeth and tonsils. This study investigates the effects of a nanotechnology antimicrobial spray (JUC) on the incidence of VAP. 320 patients diagnosed with VAP were randomly divided into treatment and control groups. After using chlorhexidine mouthrinse, the treatment group used a nanotechnology antimicrobial spray to the nose and mouth. The control group was given normal saline. The incidence rate of VAP was significantly lower in the treatment (8.38%) than control group (54.24%) (p<0.01). A physical antimicrobial film is formed on the surface of oral and nasal mucosa after using the JUC spray which effectively reduces the microbial colonization in the sprayed areas, thus reducing and delaying the incidence of VAP. © 2011 Academic Journals.
ISSN1684-5315
2011 SCImago Journal Rankings: 0.038
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLi, W
dc.contributor.authorMa, X
dc.contributor.authorPeng, Y
dc.contributor.authorCao, J
dc.contributor.authorLoo, WTY
dc.contributor.authorHao, L
dc.contributor.authorCheung, MNB
dc.contributor.authorChow, LWC
dc.contributor.authorJin, LJ
dc.date.accessioned2011-05-24T02:10:42Z
dc.date.available2011-05-24T02:10:42Z
dc.date.issued2011
dc.description.abstractVentilator-associated pneumonia (VAP) is one of the most common hospital-associated infections and has accounted for approximately 15% of all hospital-associated infections. In 76% of the VAP cases, the same bacteria colonize the oral cavity and lungs. Oral care interventions may play a role in the prevention of VAP, yet more than half of the hospitals do not have specific policies for the oral care of intubated patients. Oral cavity interlinks with respiratory tracts and digestive tracts. After surgery has been performed in these areas, aerobic and anaerobic bacteria frequently induce operative wound infections in teeth, gingiva and supporting tissues of the teeth and tonsils. This study investigates the effects of a nanotechnology antimicrobial spray (JUC) on the incidence of VAP. 320 patients diagnosed with VAP were randomly divided into treatment and control groups. After using chlorhexidine mouthrinse, the treatment group used a nanotechnology antimicrobial spray to the nose and mouth. The control group was given normal saline. The incidence rate of VAP was significantly lower in the treatment (8.38%) than control group (54.24%) (p<0.01). A physical antimicrobial film is formed on the surface of oral and nasal mucosa after using the JUC spray which effectively reduces the microbial colonization in the sprayed areas, thus reducing and delaying the incidence of VAP. © 2011 Academic Journals.
dc.description.naturepublished_or_final_version
dc.identifier.citationAfrican Journal Of Biotechnology, 2011, v. 10 n. 10, p. 1926-1931 [How to Cite?]
dc.identifier.epage1931
dc.identifier.hkuros185237
dc.identifier.issn1684-5315
2011 SCImago Journal Rankings: 0.038
dc.identifier.issue10
dc.identifier.openurl
dc.identifier.scopuseid_2-s2.0-79952640463
dc.identifier.spage1926
dc.identifier.urihttp://hdl.handle.net/10722/133569
dc.identifier.volume10
dc.languageeng
dc.publisherAcademic Journals. The Journal's web site is located at http://www.academicjournals.org/AJB/index.htm
dc.publisher.placeUnited States
dc.relation.ispartofAfrican Journal of Biotechnology
dc.relation.referencesReferences in Scopus
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subjectBacterial colonization
dc.subjectNanotechnology antimicrobial spray
dc.subjectOral care
dc.subjectVentilator-associated pneumonia
dc.titleApplication of a Nano-antimicrobial film to prevent ventilator-associated pneumonia: A pilot study
dc.typeArticle
Author Affiliations
  1. Jinan University, School of Medicine
  2. The University of Hong Kong
  3. UNIMED Medical Institute and Organisation for Oncology and Translational Research
  4. Sichuan University