File Download
  Links for fulltext
     (May Require Subscription)

Article: Voxel-based analysis of postnatal white matter microstructure in mice exposed to immune challenge in early or late pregnancy

TitleVoxel-based analysis of postnatal white matter microstructure in mice exposed to immune challenge in early or late pregnancy
Authors
KeywordsCNPase
DTI
FA
PolyIC
Prefrontal-striatal-limbic circuits
VBM
Issue Date2010
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2010, v. 52 n. 1, p. 1-8 How to Cite?
AbstractMaternal infection during prenatal life is a risk factor for neurodevelopmental disorders, including schizophrenia and autism, in the offspring. We and others have reported white mater microstructure abnormalities in prefrontal-striato-temporal networks in these disorders. In addition we have shown that early rather than late maternal immune challenge in the mouse model precipitates ventricular volume change and impairs sensorimotor gating similar to that found in schizophrenia. However, it is not known whether the timing of maternal infection has a differential impact upon white matter microstructural indices. Therefore this study directly tested the effect of early or late gestation maternal immune activation on post-natal white matter microstructure in the mouse. The viral mimic PolyI:C was administered on day 9 or day 17 of gestation. In-vivo diffusion tensor imaging (DTI) was carried out when the offspring reached adulthood. We describe a novel application of voxel-based analysis to evaluate fractional anisotrophy (FA). In addition we conducted a preliminary immunohistochemical exploration of the oligodendrocyte marker, 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), to determine whether differences in myelination might contribute to any changes in FA observed. Our results provide experimental evidence that prenatal exposure to inflammation elicits widespread differences in FA throughout fronto-striatal-limbic circuits compared to control saline exposure. Moreover, FA changes were more extensive in the group exposed earliest in gestation. © 2010 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/133534
ISSN
2015 Impact Factor: 5.463
2015 SCImago Journal Rankings: 4.464
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Qen_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorWei, Ren_HK
dc.contributor.authorCheung, Ven_HK
dc.contributor.authorHui, ESen_HK
dc.contributor.authorYou, Yen_HK
dc.contributor.authorWong, Pen_HK
dc.contributor.authorChua, SEen_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2011-05-18T03:47:55Z-
dc.date.available2011-05-18T03:47:55Z-
dc.date.issued2010en_HK
dc.identifier.citationNeuroimage, 2010, v. 52 n. 1, p. 1-8en_HK
dc.identifier.issn1053-8119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/133534-
dc.description.abstractMaternal infection during prenatal life is a risk factor for neurodevelopmental disorders, including schizophrenia and autism, in the offspring. We and others have reported white mater microstructure abnormalities in prefrontal-striato-temporal networks in these disorders. In addition we have shown that early rather than late maternal immune challenge in the mouse model precipitates ventricular volume change and impairs sensorimotor gating similar to that found in schizophrenia. However, it is not known whether the timing of maternal infection has a differential impact upon white matter microstructural indices. Therefore this study directly tested the effect of early or late gestation maternal immune activation on post-natal white matter microstructure in the mouse. The viral mimic PolyI:C was administered on day 9 or day 17 of gestation. In-vivo diffusion tensor imaging (DTI) was carried out when the offspring reached adulthood. We describe a novel application of voxel-based analysis to evaluate fractional anisotrophy (FA). In addition we conducted a preliminary immunohistochemical exploration of the oligodendrocyte marker, 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), to determine whether differences in myelination might contribute to any changes in FA observed. Our results provide experimental evidence that prenatal exposure to inflammation elicits widespread differences in FA throughout fronto-striatal-limbic circuits compared to control saline exposure. Moreover, FA changes were more extensive in the group exposed earliest in gestation. © 2010 Elsevier Inc.en_HK
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_HK
dc.relation.ispartofNeuroImageen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in NeuroImage. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in NeuroImage, 2010, v. 52 n. 1, p. 1-8. DOI: 10.1016/j.neuroimage.2010.04.015-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectCNPaseen_HK
dc.subjectDTIen_HK
dc.subjectFAen_HK
dc.subjectPolyICen_HK
dc.subjectPrefrontal-striatal-limbic circuitsen_HK
dc.subjectVBMen_HK
dc.subject.meshBrain - enzymology - pathology-
dc.subject.meshDiffusion Tensor Imaging - methods-
dc.subject.meshImage Processing, Computer-Assisted - methods-
dc.subject.meshPregnancy Complications, Infectious - immunology-
dc.subject.meshPrenatal Exposure Delayed Effects-
dc.titleVoxel-based analysis of postnatal white matter microstructure in mice exposed to immune challenge in early or late pregnancyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1053-8119&volume=52&issue=1&spage=1&epage=8&date=2010&atitle=Voxel-based+analysis+of+postnatal+white+matter+microstructure+in+mice+exposed+to+immune+challenge+in+early+or+late+pregnancy-
dc.identifier.emailCheung, C: charlton@hkucc.hku.hken_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_HK
dc.identifier.authorityCheung, C=rp01574en_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.neuroimage.2010.04.015en_HK
dc.identifier.pmid20399275-
dc.identifier.scopuseid_2-s2.0-77953290244en_HK
dc.identifier.hkuros171081-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953290244&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue1en_HK
dc.identifier.spage1en_HK
dc.identifier.epage8en_HK
dc.identifier.eissn1095-9572-
dc.identifier.isiWOS:000278637700001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, Q=22034705700en_HK
dc.identifier.scopusauthoridCheung, C=7202061845en_HK
dc.identifier.scopusauthoridWei, R=34769199800en_HK
dc.identifier.scopusauthoridCheung, V=7005439024en_HK
dc.identifier.scopusauthoridHui, ES=16175117100en_HK
dc.identifier.scopusauthoridYou, Y=36555164300en_HK
dc.identifier.scopusauthoridWong, P=36555059700en_HK
dc.identifier.scopusauthoridChua, SE=7201550427en_HK
dc.identifier.scopusauthoridMcAlonan, GM=6603123011en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.citeulike7068673-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats