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Article: Selective And Differential Binding Of Interleukin (Il)-1Α, Il-1Β, Il-2 And Il-6 To Glycosaminoglycans

TitleSelective And Differential Binding Of Interleukin (Il)-1Α, Il-1Β, Il-2 And Il-6 To Glycosaminoglycans
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1992
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.eji.de
Citation
European Journal Of Immunology, 1992, v. 22 n. 11, p. 3027-3031 How to Cite?
AbstractThe Binding Of Interleukin (Il)-1Α, Il-1Β, Il-2 And Il-6 To Acidic Polysaccharides Was Investigated By Affinity Chromatography Of The Recombinant, Radioiodinated Interleukins On Columns Of Immobilized Polysaccharide. Each Interleukin Showed Selective Binding Retention. Overall Heparin Bound All Four Interleukins Significantly, Whereas Chondroitin Sulfate Provided Little Retention. Il-1Α And Il-1Β Showed Differential Binding, With Only The Latter Binding To Hyaluronic Acid. Il-2 Was Virtually Completely Retained On Fucoidan. Noniodinated Recombinant Il-2 Bound Similarly To Fucoidan, And Fucoidan Was Found To Sequester Il-2 Activity In A Bioassay Employing Il-2-Dependent Ctll Cells. In All Other Cases Tested, Interleukin Retention Was Partial, Implying That Interleukin Binding Sites Are Sparsely Distributed Along The Polysaccharide Chains. These Findings Suggest That During The Immune Response, Interleukins Will Tend To Be Retained At Sites Of Secretion By Interaction With Glycosaminoglycans In The Extracellular Matrix And On Cell Surfaces.
Persistent Identifierhttp://hdl.handle.net/10722/133523
ISSN
2015 Impact Factor: 4.179
2015 SCImago Journal Rankings: 2.568
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRamsden, Len_US
dc.contributor.authorRider, CCen_US
dc.date.accessioned2011-05-18T02:38:45Z-
dc.date.available2011-05-18T02:38:45Z-
dc.date.issued1992en_US
dc.identifier.citationEuropean Journal Of Immunology, 1992, v. 22 n. 11, p. 3027-3031en_US
dc.identifier.issn0014-2980en_US
dc.identifier.urihttp://hdl.handle.net/10722/133523-
dc.description.abstractThe Binding Of Interleukin (Il)-1Α, Il-1Β, Il-2 And Il-6 To Acidic Polysaccharides Was Investigated By Affinity Chromatography Of The Recombinant, Radioiodinated Interleukins On Columns Of Immobilized Polysaccharide. Each Interleukin Showed Selective Binding Retention. Overall Heparin Bound All Four Interleukins Significantly, Whereas Chondroitin Sulfate Provided Little Retention. Il-1Α And Il-1Β Showed Differential Binding, With Only The Latter Binding To Hyaluronic Acid. Il-2 Was Virtually Completely Retained On Fucoidan. Noniodinated Recombinant Il-2 Bound Similarly To Fucoidan, And Fucoidan Was Found To Sequester Il-2 Activity In A Bioassay Employing Il-2-Dependent Ctll Cells. In All Other Cases Tested, Interleukin Retention Was Partial, Implying That Interleukin Binding Sites Are Sparsely Distributed Along The Polysaccharide Chains. These Findings Suggest That During The Immune Response, Interleukins Will Tend To Be Retained At Sites Of Secretion By Interaction With Glycosaminoglycans In The Extracellular Matrix And On Cell Surfaces.en_US
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.eji.deen_US
dc.relation.ispartofEuropean Journal Of Immunologyen_US
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleSelective And Differential Binding Of Interleukin (Il)-1Α, Il-1Β, Il-2 And Il-6 To Glycosaminoglycansen_US
dc.typeArticleen_US
dc.identifier.emailRamsden, L:lramsden@hkucc.hku.hken_US
dc.identifier.authorityRamsden, L=rp01484en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/eji.1830221139en_US
dc.identifier.pmid1425926-
dc.identifier.scopuseid_2-s2.0-0026475049en_US
dc.identifier.volume22en_US
dc.identifier.issue11en_US
dc.identifier.spage3027en_US
dc.identifier.epage3031en_US
dc.identifier.isiWOS:A1992JX91800038-

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