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Article: Alpha-2 agonists in acute pain management

TitleAlpha-2 agonists in acute pain management
Authors
KeywordsAcute pain
Alpha-2 agonist
Analgesia
Clonidine
Dexmedetomidine
Fadolmidine
Issue Date2010
PublisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/eop
Citation
Expert Opinion On Pharmacotherapy, 2010, v. 11 n. 17, p. 2849-2868 How to Cite?
AbstractImportance of the field: This review explores the significance of alpha-2 agonists used clinically in acute pain management. Areas covered in this review: Although alpha-2 agonists have been reported to have an analgesic effect, they are not commonly used clinically for acute pain management. Clinical studies on use of alpha-2 agonists for acute pain management are reviewed and discussed. A literature search was done using Medline with the keywords 'alpha-2 agonist', 'clonidine', 'dexmedetomidine', 'fadolmidine', 'pharmacokinetics', 'pharmacodynamics', 'postoperative analgesia', 'epidural', 'intrathecal', 'peripheral nerve block' and various combinations with these keywords. The years 1977 2009 have been included, with particular focus on clinical studies from between 1990 and 2009. What the reader will gain: This article helps to clarify the clinical use of alpha-2 agonists in acute pain management according to current, up-to-date evidence. Clinically, available alpha-2 agonists, including clonidine and dexmedetomidine, are discussed in detail. Take home message: Alpha-2 agonists, especially clonidine, seem to be promising with regard to acute postoperative pain management. However, more clinical evidence on dexmedetomidine is necessary to confirm its definite role in acute postoperative pain control. © 2010 Informa UK, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/133494
ISSN
2015 Impact Factor: 3.543
2015 SCImago Journal Rankings: 0.884
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, AKMen_HK
dc.contributor.authorCheung, CWen_HK
dc.contributor.authorChong, YKen_HK
dc.date.accessioned2011-05-16T07:30:43Z-
dc.date.available2011-05-16T07:30:43Z-
dc.date.issued2010en_HK
dc.identifier.citationExpert Opinion On Pharmacotherapy, 2010, v. 11 n. 17, p. 2849-2868en_HK
dc.identifier.issn1465-6566en_HK
dc.identifier.urihttp://hdl.handle.net/10722/133494-
dc.description.abstractImportance of the field: This review explores the significance of alpha-2 agonists used clinically in acute pain management. Areas covered in this review: Although alpha-2 agonists have been reported to have an analgesic effect, they are not commonly used clinically for acute pain management. Clinical studies on use of alpha-2 agonists for acute pain management are reviewed and discussed. A literature search was done using Medline with the keywords 'alpha-2 agonist', 'clonidine', 'dexmedetomidine', 'fadolmidine', 'pharmacokinetics', 'pharmacodynamics', 'postoperative analgesia', 'epidural', 'intrathecal', 'peripheral nerve block' and various combinations with these keywords. The years 1977 2009 have been included, with particular focus on clinical studies from between 1990 and 2009. What the reader will gain: This article helps to clarify the clinical use of alpha-2 agonists in acute pain management according to current, up-to-date evidence. Clinically, available alpha-2 agonists, including clonidine and dexmedetomidine, are discussed in detail. Take home message: Alpha-2 agonists, especially clonidine, seem to be promising with regard to acute postoperative pain management. However, more clinical evidence on dexmedetomidine is necessary to confirm its definite role in acute postoperative pain control. © 2010 Informa UK, Ltd.en_HK
dc.languageeng-
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/eopen_HK
dc.relation.ispartofExpert Opinion on Pharmacotherapyen_HK
dc.rightsExpert Opinion on Pharmacotherapy. Copyright © Informa Healthcare.-
dc.subjectAcute painen_HK
dc.subjectAlpha-2 agonisten_HK
dc.subjectAnalgesiaen_HK
dc.subjectClonidineen_HK
dc.subjectDexmedetomidineen_HK
dc.subjectFadolmidineen_HK
dc.subject.meshAcute Disease-
dc.subject.meshAdrenergic alpha-2 Receptor Agonists - pharmacology - therapeutic use-
dc.subject.meshAnalgesics - pharmacology - therapeutic use-
dc.subject.meshHumans-
dc.subject.meshPain - drug therapy-
dc.titleAlpha-2 agonists in acute pain managementen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1465-6566&volume=11&issue=17&spage=2849&epage=2868&date=2010&atitle=Alpha-2+agonists+in+acute+pain+management-
dc.identifier.emailCheung, CW:cheucw@hku.hken_HK
dc.identifier.authorityCheung, CW=rp00244en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1517/14656566.2010.511613en_HK
dc.identifier.pmid20707597-
dc.identifier.scopuseid_2-s2.0-78149421069en_HK
dc.identifier.hkuros183245-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78149421069&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue17en_HK
dc.identifier.spage2849en_HK
dc.identifier.epage2868en_HK
dc.identifier.isiWOS:000283871600008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.citeulike8239534-

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