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Article: Enteral feeding in utero induces marked intestinal structural and functional proteome changes in pig fetuses

TitleEnteral feeding in utero induces marked intestinal structural and functional proteome changes in pig fetuses
Authors
Issue Date2011
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pedresearch.org/
Citation
Pediatric Research, 2011, v. 69 n. 2, p. 123-128 How to Cite?
AbstractIntestinal adaptation from parenteral to enteral nutrition is crucial for survival and growth of newborns. Rapid feedinginduced gut maturation occurs immediately after birth in both preterm and term neonates, but it remains unclear whether the responses depend on factors related to birth transition (e.g. bacterial colonization, endocrine, and metabolic changes). We hypothesized that enteral feeding matures the immature intestine, even in fetuses before birth. Hence, control pig fetuses were compared with fetuses fed with milk formula for 24 h in utero. Gel-based proteomics showed that feeding-induced changes in 38 proteins, along with marked increases in intestinal mass and changes in activities of brush border enzymes. Physiological functions of the identified proteins were related to enterocyte apoptosis (e.g. caspase 1) and nutrient metabolism (e.g. citric acid cycle proteins). Many of the differentiated proteins were similar to those identified previously in preterm pigs fed with the same formula after birth, except that effects on proteins related to inflammatory lesions (e.g. heat shock proteins) were absent. Our results show that enteral feeding, independently of the birth transition, induces marked gut maturation and proteome change in the immature intestine. Hence, immediate postnatal feeding-induced gut changes are largely independent of factors related to the birth transition. Copyright © 2011 International Pediatric Research Foundation, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/133413
ISSN
2015 Impact Factor: 2.761
2015 SCImago Journal Rankings: 1.290
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJiang, Pen_HK
dc.contributor.authorWan, JMFen_HK
dc.contributor.authorSit, WHen_HK
dc.contributor.authorLee, CLen_HK
dc.contributor.authorSchmidt, Men_HK
dc.contributor.authorSangild, PTen_HK
dc.date.accessioned2011-05-11T08:35:44Z-
dc.date.available2011-05-11T08:35:44Z-
dc.date.issued2011en_HK
dc.identifier.citationPediatric Research, 2011, v. 69 n. 2, p. 123-128en_HK
dc.identifier.issn0031-3998en_HK
dc.identifier.urihttp://hdl.handle.net/10722/133413-
dc.description.abstractIntestinal adaptation from parenteral to enteral nutrition is crucial for survival and growth of newborns. Rapid feedinginduced gut maturation occurs immediately after birth in both preterm and term neonates, but it remains unclear whether the responses depend on factors related to birth transition (e.g. bacterial colonization, endocrine, and metabolic changes). We hypothesized that enteral feeding matures the immature intestine, even in fetuses before birth. Hence, control pig fetuses were compared with fetuses fed with milk formula for 24 h in utero. Gel-based proteomics showed that feeding-induced changes in 38 proteins, along with marked increases in intestinal mass and changes in activities of brush border enzymes. Physiological functions of the identified proteins were related to enterocyte apoptosis (e.g. caspase 1) and nutrient metabolism (e.g. citric acid cycle proteins). Many of the differentiated proteins were similar to those identified previously in preterm pigs fed with the same formula after birth, except that effects on proteins related to inflammatory lesions (e.g. heat shock proteins) were absent. Our results show that enteral feeding, independently of the birth transition, induces marked gut maturation and proteome change in the immature intestine. Hence, immediate postnatal feeding-induced gut changes are largely independent of factors related to the birth transition. Copyright © 2011 International Pediatric Research Foundation, Inc.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pedresearch.org/en_HK
dc.relation.ispartofPediatric Researchen_HK
dc.rightsThis is a non-final version of an article published in final form in (provide complete journal citation)en_US
dc.titleEnteral feeding in utero induces marked intestinal structural and functional proteome changes in pig fetusesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0031-3998&volume=69&issue=2&spage=123&epage=128&date=2011&atitle=Enteral+feeding+in+utero+induces+marked+intestinal+structural+and+functional+proteome+changes+in+pig+fetusesen_US
dc.identifier.emailWan, JMF: jmfwan@hku.hken_HK
dc.identifier.authorityWan, JMF=rp00798en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1203/PDR.0b013e3182042874en_HK
dc.identifier.pmid21045752-
dc.identifier.scopuseid_2-s2.0-79951641821en_HK
dc.identifier.hkuros184820en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79951641821&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume69en_HK
dc.identifier.issue2en_HK
dc.identifier.spage123en_HK
dc.identifier.epage128en_HK
dc.identifier.eissn1530-0447-
dc.identifier.isiWOS:000286555200006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridJiang, P=36147603700en_HK
dc.identifier.scopusauthoridWan, JMF=8930305000en_HK
dc.identifier.scopusauthoridSit, WH=8528923000en_HK
dc.identifier.scopusauthoridLee, CL=9277221100en_HK
dc.identifier.scopusauthoridSchmidt, M=7404398647en_HK
dc.identifier.scopusauthoridSangild, PT=7004115316en_HK

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