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Article: Associations of diabetes mellitus with site-specific cancer mortality in the Asia-Pacific region

TitleAssociations of diabetes mellitus with site-specific cancer mortality in the Asia-Pacific region
Authors
KeywordsAsia-Pacific
Cancer mortality
Diabetes mellitus
Epidemiology
Issue Date2011
PublisherOxford University Press. The Journal's web site is located at http://annonc.oxfordjournals.org/
Citation
Annals Of Oncology, 2011, v. 22 n. 3, p. 730-738 How to Cite?
AbstractBackground: Owing to the increasing prevalence of obesity and diabetes in Asia, and the paucity of studies, we examined the influence of raised blood glucose and diabetes on cancer mortality risk. Materials and methods: Thirty-six cohort Asian and Australasian studies provided 367 361 participants (74% from Asia); 6% had diabetes at baseline. Associations between diabetes and site-specific cancer mortality were estimated using time-dependent Cox models, stratified by study and sex, and adjusted for age. Results: During a median follow-up of 4.0 years, there were 5992 deaths due to cancer (74% Asian; 41% female). Participants with diabetes had 23% greater risk of mortality from all-cause cancer compared with those without: hazard ratio (HR) 1.23 [95% confidence interval (CI) 1.12, 1.35]. Diabetes was associated with mortality due to cancer of the liver (HR 1.51; 95% CI 1.19, 1.91), pancreas (HR 1.78; 95% CI 1.20, 2.65), and, less strongly, colorectum (HR 1.32; 95% CI 0.98, 1.78). There was no evidence of sex- or region-specific differences in these associations. The population attributable fractions for cancer mortality due to diabetes were generally higher for Asia compared with non-Asian populations. Conclusion: Diabetes is associated with increased mortality from selected cancers in Asian and non-Asian populations. © The Author 2010. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/133342
ISSN
2015 Impact Factor: 9.269
2015 SCImago Journal Rankings: 4.362
ISI Accession Number ID
Funding AgencyGrant Number
Heart Foundation of Australia
Canadian Institutes of Health Research
Queen's University
UK MRC
Chief Scientist Office at the Scottish Government Health Directorates
AstraZeneca
GlaxoSmithKline
Funding Information:

Heart Foundation of Australia Career Development Award to RRH; Canadian Institutes of Health Research Fellowship to ALCM; Queen's University Community Medicine and Family Medicine Post-Graduate Medical Residency Program to EL. GDB is a Wellcome Trust Career Development Fellow. The Medical Research Council (MRC) Social and Public Health Sciences Unit receives funding from the UK MRC and the Chief Scientist Office at the Scottish Government Health Directorates.

References

 

DC FieldValueLanguage
dc.contributor.authorLam, EKKen_HK
dc.contributor.authorBatty, GDen_HK
dc.contributor.authorHuxley, RRen_HK
dc.contributor.authorMartiniuk, ALCen_HK
dc.contributor.authorBarzi, Fen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLawes, CMMen_HK
dc.contributor.authorGiles, GGen_HK
dc.contributor.authorWelborn, Ten_HK
dc.contributor.authorUeshima, Hen_HK
dc.contributor.authorTamakoshi, Aen_HK
dc.contributor.authorWoo, Jen_HK
dc.contributor.authorKim, HCen_HK
dc.contributor.authorFang, Xen_HK
dc.contributor.authorCzernichow, Sen_HK
dc.contributor.authorWoodward, Men_HK
dc.date.accessioned2011-05-11T08:32:23Z-
dc.date.available2011-05-11T08:32:23Z-
dc.date.issued2011en_HK
dc.identifier.citationAnnals Of Oncology, 2011, v. 22 n. 3, p. 730-738en_HK
dc.identifier.issn0923-7534en_HK
dc.identifier.urihttp://hdl.handle.net/10722/133342-
dc.description.abstractBackground: Owing to the increasing prevalence of obesity and diabetes in Asia, and the paucity of studies, we examined the influence of raised blood glucose and diabetes on cancer mortality risk. Materials and methods: Thirty-six cohort Asian and Australasian studies provided 367 361 participants (74% from Asia); 6% had diabetes at baseline. Associations between diabetes and site-specific cancer mortality were estimated using time-dependent Cox models, stratified by study and sex, and adjusted for age. Results: During a median follow-up of 4.0 years, there were 5992 deaths due to cancer (74% Asian; 41% female). Participants with diabetes had 23% greater risk of mortality from all-cause cancer compared with those without: hazard ratio (HR) 1.23 [95% confidence interval (CI) 1.12, 1.35]. Diabetes was associated with mortality due to cancer of the liver (HR 1.51; 95% CI 1.19, 1.91), pancreas (HR 1.78; 95% CI 1.20, 2.65), and, less strongly, colorectum (HR 1.32; 95% CI 0.98, 1.78). There was no evidence of sex- or region-specific differences in these associations. The population attributable fractions for cancer mortality due to diabetes were generally higher for Asia compared with non-Asian populations. Conclusion: Diabetes is associated with increased mortality from selected cancers in Asian and non-Asian populations. © The Author 2010. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://annonc.oxfordjournals.org/en_HK
dc.relation.ispartofAnnals of Oncologyen_HK
dc.subjectAsia-Pacificen_HK
dc.subjectCancer mortalityen_HK
dc.subjectDiabetes mellitusen_HK
dc.subjectEpidemiologyen_HK
dc.subject.meshBlood Glucose-
dc.subject.meshDiabetes Complications - complications - mortality-
dc.subject.meshAdult-
dc.subject.meshNeoplasms - complications - mortality-
dc.subject.meshAged, 80 and over-
dc.titleAssociations of diabetes mellitus with site-specific cancer mortality in the Asia-Pacific regionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0923-7534&volume=22&issue=3&spage=730&epage=738&date=2011&atitle=Associations+of+diabetes+mellitus+with+site-specific+cancer+mortality+in+the+Asia-Pacific+region-
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/annonc/mdq405en_HK
dc.identifier.pmid20705912-
dc.identifier.scopuseid_2-s2.0-79952034197en_HK
dc.identifier.hkuros184994en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952034197&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue3en_HK
dc.identifier.spage730en_HK
dc.identifier.epage738en_HK
dc.identifier.isiWOS:000287750700032-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, EKK=36787211300en_HK
dc.identifier.scopusauthoridBatty, GD=7003988354en_HK
dc.identifier.scopusauthoridHuxley, RR=6701828350en_HK
dc.identifier.scopusauthoridMartiniuk, ALC=15835035500en_HK
dc.identifier.scopusauthoridBarzi, F=7003545543en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridLawes, CMM=6602516713en_HK
dc.identifier.scopusauthoridGiles, GG=7103091133en_HK
dc.identifier.scopusauthoridWelborn, T=7005408607en_HK
dc.identifier.scopusauthoridUeshima, H=7005129002en_HK
dc.identifier.scopusauthoridTamakoshi, A=7006797376en_HK
dc.identifier.scopusauthoridWoo, J=36040369400en_HK
dc.identifier.scopusauthoridKim, HC=17137062600en_HK
dc.identifier.scopusauthoridFang, X=15834725000en_HK
dc.identifier.scopusauthoridCzernichow, S=35229348600en_HK
dc.identifier.scopusauthoridWoodward, M=7102510958en_HK
dc.identifier.citeulike8948973-

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