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Article: Lower lung cancer mortality in obesity

TitleLower lung cancer mortality in obesity
Authors
KeywordsBody mass index
Lung cancer
Mortality
Issue Date2011
PublisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/
Citation
International Journal Of Epidemiology, 2011, v. 40 n. 1, p. 174-182 How to Cite?
AbstractBackground: Malignancy is the leading cause of death in Hong Kong, and lung cancer tops the list of all cancer deaths. Methods: A cohort of clients aged ≥65 years, enrolled at 18 elderly health centres in Hong Kong from 2000 to 2003, was followed up prospectively through linkage with the territory-wide death registry for causes of death until 31 December 2008, using the identity card number as unique identifier. All subjects with suspected cancer, significant weight loss of>5% within past 6 months or obstructive lung disease at the baseline were excluded. Results: After a total of 423 061 person-years of follow-up, 932, 690 and 1433 deaths were caused by lung cancer, other tobacco-related malignancies and non-tobacco-related malignancies, respectively. Body mass index (BMI) was independently (and negatively) associated with death from lung cancer after adjustment for other baseline variables, whereas there was only a minor or no effect for other smoking-related malignancies and non-tobacco-related malignancies. Obesity with BMI≥30 [adjusted hazard ratio (HR), 0.55, 95% confidence interval (CI) 0.38-0.80] was associated with reduced lung cancer mortality, which was more prominent than the opposing effect of underweight (adjusted HR, 1.38, 95% CI 1.05-1.79). Consistent effects of BMI were observed after stratification into never-smokers and ever-smokers and in sensitivity analysis after excluding deaths within the first 3 years. Conclusion: Obesity was associated with lower lung cancer mortality in this prospective cohort analysis. As the effect was rather specific for lung cancer, further studies are indicated to explore the underlying mechanism. © The Author 2010. Published by Oxford University Press on behalf of the International Epidemiological Association. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/133341
ISSN
2014 Impact Factor: 9.176
2013 SCImago Journal Rankings: 4.074
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, CCen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorYew, WWen_HK
dc.contributor.authorChan, WMen_HK
dc.contributor.authorLaw, WSen_HK
dc.contributor.authorTam, CMen_HK
dc.date.accessioned2011-05-11T08:32:22Z-
dc.date.available2011-05-11T08:32:22Z-
dc.date.issued2011en_HK
dc.identifier.citationInternational Journal Of Epidemiology, 2011, v. 40 n. 1, p. 174-182en_HK
dc.identifier.issn0300-5771en_HK
dc.identifier.urihttp://hdl.handle.net/10722/133341-
dc.description.abstractBackground: Malignancy is the leading cause of death in Hong Kong, and lung cancer tops the list of all cancer deaths. Methods: A cohort of clients aged ≥65 years, enrolled at 18 elderly health centres in Hong Kong from 2000 to 2003, was followed up prospectively through linkage with the territory-wide death registry for causes of death until 31 December 2008, using the identity card number as unique identifier. All subjects with suspected cancer, significant weight loss of>5% within past 6 months or obstructive lung disease at the baseline were excluded. Results: After a total of 423 061 person-years of follow-up, 932, 690 and 1433 deaths were caused by lung cancer, other tobacco-related malignancies and non-tobacco-related malignancies, respectively. Body mass index (BMI) was independently (and negatively) associated with death from lung cancer after adjustment for other baseline variables, whereas there was only a minor or no effect for other smoking-related malignancies and non-tobacco-related malignancies. Obesity with BMI≥30 [adjusted hazard ratio (HR), 0.55, 95% confidence interval (CI) 0.38-0.80] was associated with reduced lung cancer mortality, which was more prominent than the opposing effect of underweight (adjusted HR, 1.38, 95% CI 1.05-1.79). Consistent effects of BMI were observed after stratification into never-smokers and ever-smokers and in sensitivity analysis after excluding deaths within the first 3 years. Conclusion: Obesity was associated with lower lung cancer mortality in this prospective cohort analysis. As the effect was rather specific for lung cancer, further studies are indicated to explore the underlying mechanism. © The Author 2010. Published by Oxford University Press on behalf of the International Epidemiological Association. All rights reserved.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/en_HK
dc.relation.ispartofInternational Journal of Epidemiologyen_HK
dc.subjectBody mass indexen_HK
dc.subjectLung canceren_HK
dc.subjectMortalityen_HK
dc.titleLower lung cancer mortality in obesityen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-5771&volume=40&issue=1&spage=174&epage=182&date=2011&atitle=Lower+lung+cancer+mortality+in+obesity-
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/ije/dyq134en_HK
dc.identifier.pmid20709687en_HK
dc.identifier.scopuseid_2-s2.0-79952049461en_HK
dc.identifier.hkuros184993en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952049461&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume40en_HK
dc.identifier.issue1en_HK
dc.identifier.spage174en_HK
dc.identifier.epage182en_HK
dc.identifier.isiWOS:000288720900021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLeung, CC=7402612644en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridYew, WW=7005934631en_HK
dc.identifier.scopusauthoridChan, WM=7403914485en_HK
dc.identifier.scopusauthoridLaw, WS=7103147875en_HK
dc.identifier.scopusauthoridTam, CM=7201442997en_HK

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