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Article: Plasminogen activator inhibitor-1 and HbA1c defined prediabetes: The Guangzhou Biobank Cohort Study-CVD

TitlePlasminogen activator inhibitor-1 and HbA1c defined prediabetes: The Guangzhou Biobank Cohort Study-CVD
Authors
Issue Date2011
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664
Citation
Clinical Endocrinology, 2011, v. 74 n. 4, p. 528-531 How to Cite?
AbstractObjective To examine the association between plasminogen activator inhibitor-1 (PAI-1) and diabetes status. Research Design and Methods One thousand three hundred and ninety-three older Chinese were randomly selected from the Guangzhou Biobank Cohort Study. Diabetes status was classified as impaired HbA1c (IA1c) level of 5·7-6·4%, impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or diabetes using the American Diabetes Association diagnosis criteria in 2010. Results Compared to the normoglycemic (NG) group, 421 subjects with IA1c, but without diabetes, IFG or IGT, had adverse levels of vascular risk factors, including PAI-1, lipid profile, blood pressure and anthropometry. After adjusting for multiple potential confounders, compared to the NG group, the level of plasma PAI-1 was independently and significantly increased in the IA1c and the IFG/IGT group (mean difference: 32·0 (95% confidence interval: 5·5-58·6) ng/ml and 33·3 (6·3-60·3) ng/ml, respectively; P < 0·01). Conclusions Plasma PAI-1 level was increased in people with haemoglobin A1c (HbA1c) of 5·7-6·4% but without IFG or IGT, and in people with IFG/IGT, suggesting an increased risk for future diabetes and cardiovascular diseases in these groups. © 2011 Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/133339
ISSN
2014 Impact Factor: 3.457
2014 SCImago Journal Rankings: 1.136
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China/Research Grants Council30518001
HKU720/05
University of Hong Kong Foundation for Education and Science, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, UK
Funding Information:

The study is funded by the National Natural Science Foundation of China/Research Grants Council (No. 30518001; HKU720/05) grant. The main cohort study was funded by The University of Hong Kong Foundation for Education and Science, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and The University of Birmingham, UK.

References

 

DC FieldValueLanguage
dc.contributor.authorXu, Len_HK
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorBao, Ben_HK
dc.contributor.authorCheng, KKen_HK
dc.contributor.authorThomas, GNen_HK
dc.date.accessioned2011-05-11T08:32:21Z-
dc.date.available2011-05-11T08:32:21Z-
dc.date.issued2011en_HK
dc.identifier.citationClinical Endocrinology, 2011, v. 74 n. 4, p. 528-531en_HK
dc.identifier.issn0300-0664en_HK
dc.identifier.urihttp://hdl.handle.net/10722/133339-
dc.description.abstractObjective To examine the association between plasminogen activator inhibitor-1 (PAI-1) and diabetes status. Research Design and Methods One thousand three hundred and ninety-three older Chinese were randomly selected from the Guangzhou Biobank Cohort Study. Diabetes status was classified as impaired HbA1c (IA1c) level of 5·7-6·4%, impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or diabetes using the American Diabetes Association diagnosis criteria in 2010. Results Compared to the normoglycemic (NG) group, 421 subjects with IA1c, but without diabetes, IFG or IGT, had adverse levels of vascular risk factors, including PAI-1, lipid profile, blood pressure and anthropometry. After adjusting for multiple potential confounders, compared to the NG group, the level of plasma PAI-1 was independently and significantly increased in the IA1c and the IFG/IGT group (mean difference: 32·0 (95% confidence interval: 5·5-58·6) ng/ml and 33·3 (6·3-60·3) ng/ml, respectively; P < 0·01). Conclusions Plasma PAI-1 level was increased in people with haemoglobin A1c (HbA1c) of 5·7-6·4% but without IFG or IGT, and in people with IFG/IGT, suggesting an increased risk for future diabetes and cardiovascular diseases in these groups. © 2011 Blackwell Publishing Ltd.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0300-0664en_HK
dc.relation.ispartofClinical Endocrinologyen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.titlePlasminogen activator inhibitor-1 and HbA1c defined prediabetes: The Guangzhou Biobank Cohort Study-CVDen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-0664&volume=74&issue=4&spage=528&epage=531&date=2011&atitle=Plasminogen+activator+inhibitor-1+and+HbA1c+defined+prediabetes:+The+Guangzhou+Biobank+Cohort+Study-CVD-
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2265.2010.03948.xen_HK
dc.identifier.pmid21128994-
dc.identifier.scopuseid_2-s2.0-79952437473en_HK
dc.identifier.hkuros184991en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952437473&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume74en_HK
dc.identifier.issue4en_HK
dc.identifier.spage528en_HK
dc.identifier.epage531en_HK
dc.identifier.isiWOS:000288073300018-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridXu, L=35180837300en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridBao, B=47461002600en_HK
dc.identifier.scopusauthoridCheng, KK=7402997800en_HK
dc.identifier.scopusauthoridThomas, GN=35465269900en_HK
dc.identifier.citeulike9000220-

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