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Article: Atrial fibrillation and obesity among older Chinese: The Guangzhou Biobank Cohort Study
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TitleAtrial fibrillation and obesity among older Chinese: The Guangzhou Biobank Cohort Study
 
AuthorsLong, MJ1
Jiang, CQ2
Lam, TH1
Xu, L1 2
Zhang, WS2
Lin, JM2
Ou, JP2
Cheng, KK3
 
Issue Date2011
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
 
CitationInternational Journal Of Cardiology, 2011, v. 148 n. 1, p. 48-52 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2009.10.022
 
AbstractBackground: Atrial fibrillation (AF) is the most common form of arrhythmia, and its prevalence is increasing. Few studies have examined its association with obesity as defined by different criteria, particularly in developing countries. We investigated the association between atrial fibrillation (AF) and obesity indices among older Chinese. Methods: We conducted a community-based nested case control study using cross-sectional data of 5882 men and 14,548 women aged 50 or above from Phases I and II (September 2003 to May 2006) of the Guangzhou Biobank Cohort Study (GBCS). AF cases were identified by the 12-lead body surface electrocardiogram. Results: 159 AF cases (65 men and 94 women) were identified from 19,964 participants with ECG records. 9249 participants with other abnormal ECG findings were excluded, resulting in a case control comparison on 159 AF cases and 10,369 controls. After multivariate adjustment, BMI (adjusted odds ratio (OR) 1.06 per kg/m 2, 95% confidence interval (CI) = 1.01-1.11) and waist circumference (adjusted OR 1.02 per cm (1.00-1.04)) were significant risk factors. The adjusted OR per Z-score [(individual value - mean) / standard deviation] for BMI and waist circumference was 1.21 (1.03-1.41) and 1.18 (1.01-1.38) respectively. Conclusions: This is the first report showing that both general and central obesity are associated with increased risk of AF in an Eastern population with much lower level of obesity than in the West. As both AF and obesity are increasing in developing countries, the results should have important public health implications. © 2009 Elsevier Ireland Ltd.
 
ISSN0167-5273
2012 Impact Factor: 5.509
2012 SCImago Journal Rankings: 0.788
 
DOIhttp://dx.doi.org/10.1016/j.ijcard.2009.10.022
 
ISI Accession Number IDWOS:000288489300016
Funding AgencyGrant Number
University of Hong Kong Foundation for Educational Development and Research, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, UK
Funding Information:

The study was funded by the University of Hong Kong Foundation for Educational Development and Research, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and the University of Birmingham, UK. The authors of this manuscript have certified that they comply with the Principles of Ethical Publishing in the International Journal of Cardiology [31].

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLong, MJ
 
dc.contributor.authorJiang, CQ
 
dc.contributor.authorLam, TH
 
dc.contributor.authorXu, L
 
dc.contributor.authorZhang, WS
 
dc.contributor.authorLin, JM
 
dc.contributor.authorOu, JP
 
dc.contributor.authorCheng, KK
 
dc.date.accessioned2011-05-11T08:32:19Z
 
dc.date.available2011-05-11T08:32:19Z
 
dc.date.issued2011
 
dc.description.abstractBackground: Atrial fibrillation (AF) is the most common form of arrhythmia, and its prevalence is increasing. Few studies have examined its association with obesity as defined by different criteria, particularly in developing countries. We investigated the association between atrial fibrillation (AF) and obesity indices among older Chinese. Methods: We conducted a community-based nested case control study using cross-sectional data of 5882 men and 14,548 women aged 50 or above from Phases I and II (September 2003 to May 2006) of the Guangzhou Biobank Cohort Study (GBCS). AF cases were identified by the 12-lead body surface electrocardiogram. Results: 159 AF cases (65 men and 94 women) were identified from 19,964 participants with ECG records. 9249 participants with other abnormal ECG findings were excluded, resulting in a case control comparison on 159 AF cases and 10,369 controls. After multivariate adjustment, BMI (adjusted odds ratio (OR) 1.06 per kg/m 2, 95% confidence interval (CI) = 1.01-1.11) and waist circumference (adjusted OR 1.02 per cm (1.00-1.04)) were significant risk factors. The adjusted OR per Z-score [(individual value - mean) / standard deviation] for BMI and waist circumference was 1.21 (1.03-1.41) and 1.18 (1.01-1.38) respectively. Conclusions: This is the first report showing that both general and central obesity are associated with increased risk of AF in an Eastern population with much lower level of obesity than in the West. As both AF and obesity are increasing in developing countries, the results should have important public health implications. © 2009 Elsevier Ireland Ltd.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationInternational Journal Of Cardiology, 2011, v. 148 n. 1, p. 48-52 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2009.10.022
 
dc.identifier.citeulike6255513
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijcard.2009.10.022
 
dc.identifier.epage52
 
dc.identifier.hkuros184816
 
dc.identifier.isiWOS:000288489300016
Funding AgencyGrant Number
University of Hong Kong Foundation for Educational Development and Research, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, UK
Funding Information:

The study was funded by the University of Hong Kong Foundation for Educational Development and Research, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and the University of Birmingham, UK. The authors of this manuscript have certified that they comply with the Principles of Ethical Publishing in the International Journal of Cardiology [31].

 
dc.identifier.issn0167-5273
2012 Impact Factor: 5.509
2012 SCImago Journal Rankings: 0.788
 
dc.identifier.issue1
 
dc.identifier.pmid19944468
 
dc.identifier.scopuseid_2-s2.0-79952897782
 
dc.identifier.spage48
 
dc.identifier.urihttp://hdl.handle.net/10722/133336
 
dc.identifier.volume148
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
 
dc.publisher.placeIreland
 
dc.relation.ispartofInternational Journal of Cardiology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAge Factors
 
dc.subject.meshAged
 
dc.subject.meshAsian Continental Ancestry Group - ethnology
 
dc.subject.meshAtrial Fibrillation - ethnology - etiology - physiopathology
 
dc.subject.meshCase-Control Studies
 
dc.subject.meshCohort Studies
 
dc.subject.meshCross-Sectional Studies
 
dc.subject.meshDatabases, Factual
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshObesity - complications - ethnology - physiopathology
 
dc.subject.meshWaist Circumference - physiology
 
dc.titleAtrial fibrillation and obesity among older Chinese: The Guangzhou Biobank Cohort Study
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Guangzhou No. 12 Hospital
  3. University of Birmingham