Article: Atrial fibrillation and obesity among older Chinese: The Guangzhou Biobank Cohort Study
| Title | Atrial fibrillation and obesity among older Chinese: The Guangzhou Biobank Cohort Study | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Authors | Long, MJ1 Jiang, CQ2 Lam, TH1 Xu, L1 2 Zhang, WS2 Lin, JM2 Ou, JP2 Cheng, KK3 | ||||||||||
| Issue Date | 2011 | ||||||||||
| Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard | ||||||||||
| Citation | International Journal Of Cardiology, 2011, v. 148 n. 1, p. 48-52 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.ijcard.2009.10.022 | ||||||||||
| Abstract | Background: Atrial fibrillation (AF) is the most common form of arrhythmia, and its prevalence is increasing. Few studies have examined its association with obesity as defined by different criteria, particularly in developing countries. We investigated the association between atrial fibrillation (AF) and obesity indices among older Chinese. Methods: We conducted a community-based nested case control study using cross-sectional data of 5882 men and 14,548 women aged 50 or above from Phases I and II (September 2003 to May 2006) of the Guangzhou Biobank Cohort Study (GBCS). AF cases were identified by the 12-lead body surface electrocardiogram. Results: 159 AF cases (65 men and 94 women) were identified from 19,964 participants with ECG records. 9249 participants with other abnormal ECG findings were excluded, resulting in a case control comparison on 159 AF cases and 10,369 controls. After multivariate adjustment, BMI (adjusted odds ratio (OR) 1.06 per kg/m 2, 95% confidence interval (CI) = 1.01-1.11) and waist circumference (adjusted OR 1.02 per cm (1.00-1.04)) were significant risk factors. The adjusted OR per Z-score [(individual value - mean) / standard deviation] for BMI and waist circumference was 1.21 (1.03-1.41) and 1.18 (1.01-1.38) respectively. Conclusions: This is the first report showing that both general and central obesity are associated with increased risk of AF in an Eastern population with much lower level of obesity than in the West. As both AF and obesity are increasing in developing countries, the results should have important public health implications. © 2009 Elsevier Ireland Ltd. | ||||||||||
| ISSN | 0167-5273 2011 Impact Factor: 7.078 2011 SCImago Journal Rankings: 0.144 | ||||||||||
| DOI | http://dx.doi.org/10.1016/j.ijcard.2009.10.022 | ||||||||||
| ISI Accession Number ID | WOS:000288489300016
Funding Information: The study was funded by the University of Hong Kong Foundation for Educational Development and Research, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and the University of Birmingham, UK. The authors of this manuscript have certified that they comply with the Principles of Ethical Publishing in the International Journal of Cardiology [31]. | ||||||||||
| References | References in Scopus |
| dc.contributor.author | Long, MJ | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| dc.contributor.author | Jiang, CQ | ||||||||||
| dc.contributor.author | Lam, TH | ||||||||||
| dc.contributor.author | Xu, L | ||||||||||
| dc.contributor.author | Zhang, WS | ||||||||||
| dc.contributor.author | Lin, JM | ||||||||||
| dc.contributor.author | Ou, JP | ||||||||||
| dc.contributor.author | Cheng, KK | ||||||||||
| dc.date.accessioned | 2011-05-11T08:32:19Z | ||||||||||
| dc.date.available | 2011-05-11T08:32:19Z | ||||||||||
| dc.date.issued | 2011 | ||||||||||
| dc.description.abstract | Background: Atrial fibrillation (AF) is the most common form of arrhythmia, and its prevalence is increasing. Few studies have examined its association with obesity as defined by different criteria, particularly in developing countries. We investigated the association between atrial fibrillation (AF) and obesity indices among older Chinese. Methods: We conducted a community-based nested case control study using cross-sectional data of 5882 men and 14,548 women aged 50 or above from Phases I and II (September 2003 to May 2006) of the Guangzhou Biobank Cohort Study (GBCS). AF cases were identified by the 12-lead body surface electrocardiogram. Results: 159 AF cases (65 men and 94 women) were identified from 19,964 participants with ECG records. 9249 participants with other abnormal ECG findings were excluded, resulting in a case control comparison on 159 AF cases and 10,369 controls. After multivariate adjustment, BMI (adjusted odds ratio (OR) 1.06 per kg/m 2, 95% confidence interval (CI) = 1.01-1.11) and waist circumference (adjusted OR 1.02 per cm (1.00-1.04)) were significant risk factors. The adjusted OR per Z-score [(individual value - mean) / standard deviation] for BMI and waist circumference was 1.21 (1.03-1.41) and 1.18 (1.01-1.38) respectively. Conclusions: This is the first report showing that both general and central obesity are associated with increased risk of AF in an Eastern population with much lower level of obesity than in the West. As both AF and obesity are increasing in developing countries, the results should have important public health implications. © 2009 Elsevier Ireland Ltd. | ||||||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||||||
| dc.identifier.citation | International Journal Of Cardiology, 2011, v. 148 n. 1, p. 48-52 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.ijcard.2009.10.022 | ||||||||||
| dc.identifier.citeulike | 6255513 | ||||||||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.ijcard.2009.10.022 | ||||||||||
| dc.identifier.epage | 52 | ||||||||||
| dc.identifier.hkuros | 184816 | ||||||||||
| dc.identifier.isi | WOS:000288489300016
Funding Information: The study was funded by the University of Hong Kong Foundation for Educational Development and Research, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and the University of Birmingham, UK. The authors of this manuscript have certified that they comply with the Principles of Ethical Publishing in the International Journal of Cardiology [31]. | ||||||||||
| dc.identifier.issn | 0167-5273 2011 Impact Factor: 7.078 2011 SCImago Journal Rankings: 0.144 | ||||||||||
| dc.identifier.issue | 1 | ||||||||||
| dc.identifier.pmid | 19944468 | ||||||||||
| dc.identifier.scopus | eid_2-s2.0-79952897782 | ||||||||||
| dc.identifier.spage | 48 | ||||||||||
| dc.identifier.uri | http://hdl.handle.net/10722/133336 | ||||||||||
| dc.identifier.volume | 148 | ||||||||||
| dc.language | eng | ||||||||||
| dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard | ||||||||||
| dc.publisher.place | Ireland | ||||||||||
| dc.relation.ispartof | International Journal of Cardiology | ||||||||||
| dc.relation.references | References in Scopus | ||||||||||
| dc.subject.mesh | Age Factors | ||||||||||
| dc.subject.mesh | Aged | ||||||||||
| dc.subject.mesh | Asian Continental Ancestry Group - ethnology | ||||||||||
| dc.subject.mesh | Atrial Fibrillation - ethnology - etiology - physiopathology | ||||||||||
| dc.subject.mesh | Case-Control Studies | ||||||||||
| dc.subject.mesh | Cohort Studies | ||||||||||
| dc.subject.mesh | Cross-Sectional Studies | ||||||||||
| dc.subject.mesh | Databases, Factual | ||||||||||
| dc.subject.mesh | Female | ||||||||||
| dc.subject.mesh | Humans | ||||||||||
| dc.subject.mesh | Male | ||||||||||
| dc.subject.mesh | Middle Aged | ||||||||||
| dc.subject.mesh | Obesity - complications - ethnology - physiopathology | ||||||||||
| dc.subject.mesh | Waist Circumference - physiology | ||||||||||
| dc.title | Atrial fibrillation and obesity among older Chinese: The Guangzhou Biobank Cohort Study | ||||||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong
- Guangzhou No. 12 Hospital
- University of Birmingham