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Article: Atrial fibrillation and obesity among older Chinese: The Guangzhou Biobank Cohort Study

TitleAtrial fibrillation and obesity among older Chinese: The Guangzhou Biobank Cohort Study
Authors
Issue Date2011
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
Citation
International Journal Of Cardiology, 2011, v. 148 n. 1, p. 48-52 How to Cite?
Abstract
Background: Atrial fibrillation (AF) is the most common form of arrhythmia, and its prevalence is increasing. Few studies have examined its association with obesity as defined by different criteria, particularly in developing countries. We investigated the association between atrial fibrillation (AF) and obesity indices among older Chinese. Methods: We conducted a community-based nested case control study using cross-sectional data of 5882 men and 14,548 women aged 50 or above from Phases I and II (September 2003 to May 2006) of the Guangzhou Biobank Cohort Study (GBCS). AF cases were identified by the 12-lead body surface electrocardiogram. Results: 159 AF cases (65 men and 94 women) were identified from 19,964 participants with ECG records. 9249 participants with other abnormal ECG findings were excluded, resulting in a case control comparison on 159 AF cases and 10,369 controls. After multivariate adjustment, BMI (adjusted odds ratio (OR) 1.06 per kg/m 2, 95% confidence interval (CI) = 1.01-1.11) and waist circumference (adjusted OR 1.02 per cm (1.00-1.04)) were significant risk factors. The adjusted OR per Z-score [(individual value - mean) / standard deviation] for BMI and waist circumference was 1.21 (1.03-1.41) and 1.18 (1.01-1.38) respectively. Conclusions: This is the first report showing that both general and central obesity are associated with increased risk of AF in an Eastern population with much lower level of obesity than in the West. As both AF and obesity are increasing in developing countries, the results should have important public health implications. © 2009 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/133336
ISSN
2013 Impact Factor: 6.175
2013 SCImago Journal Rankings: 0.930
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong Foundation for Educational Development and Research, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Committee, Guangzhou, China
University of Birmingham, UK
Funding Information:

The study was funded by the University of Hong Kong Foundation for Educational Development and Research, Hong Kong; Guangzhou Public Health Bureau, and Guangzhou Science and Technology Committee, Guangzhou, China; and the University of Birmingham, UK. The authors of this manuscript have certified that they comply with the Principles of Ethical Publishing in the International Journal of Cardiology [31].

References

 

Author Affiliations
  1. The University of Hong Kong
  2. Guangzhou No. 12 Hospital
  3. University of Birmingham
DC FieldValueLanguage
dc.contributor.authorLong, MJen_HK
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorXu, Len_HK
dc.contributor.authorZhang, WSen_HK
dc.contributor.authorLin, JMen_HK
dc.contributor.authorOu, JPen_HK
dc.contributor.authorCheng, KKen_HK
dc.date.accessioned2011-05-11T08:32:19Z-
dc.date.available2011-05-11T08:32:19Z-
dc.date.issued2011en_HK
dc.identifier.citationInternational Journal Of Cardiology, 2011, v. 148 n. 1, p. 48-52en_HK
dc.identifier.issn0167-5273en_HK
dc.identifier.urihttp://hdl.handle.net/10722/133336-
dc.description.abstractBackground: Atrial fibrillation (AF) is the most common form of arrhythmia, and its prevalence is increasing. Few studies have examined its association with obesity as defined by different criteria, particularly in developing countries. We investigated the association between atrial fibrillation (AF) and obesity indices among older Chinese. Methods: We conducted a community-based nested case control study using cross-sectional data of 5882 men and 14,548 women aged 50 or above from Phases I and II (September 2003 to May 2006) of the Guangzhou Biobank Cohort Study (GBCS). AF cases were identified by the 12-lead body surface electrocardiogram. Results: 159 AF cases (65 men and 94 women) were identified from 19,964 participants with ECG records. 9249 participants with other abnormal ECG findings were excluded, resulting in a case control comparison on 159 AF cases and 10,369 controls. After multivariate adjustment, BMI (adjusted odds ratio (OR) 1.06 per kg/m 2, 95% confidence interval (CI) = 1.01-1.11) and waist circumference (adjusted OR 1.02 per cm (1.00-1.04)) were significant risk factors. The adjusted OR per Z-score [(individual value - mean) / standard deviation] for BMI and waist circumference was 1.21 (1.03-1.41) and 1.18 (1.01-1.38) respectively. Conclusions: This is the first report showing that both general and central obesity are associated with increased risk of AF in an Eastern population with much lower level of obesity than in the West. As both AF and obesity are increasing in developing countries, the results should have important public health implications. © 2009 Elsevier Ireland Ltd.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcarden_HK
dc.relation.ispartofInternational Journal of Cardiologyen_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAsian Continental Ancestry Group - ethnologyen_HK
dc.subject.meshAtrial Fibrillation - ethnology - etiology - physiopathologyen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshDatabases, Factualen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshObesity - complications - ethnology - physiopathologyen_HK
dc.subject.meshWaist Circumference - physiologyen_HK
dc.titleAtrial fibrillation and obesity among older Chinese: The Guangzhou Biobank Cohort Studyen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijcard.2009.10.022en_HK
dc.identifier.pmid19944468en_HK
dc.identifier.scopuseid_2-s2.0-79952897782en_HK
dc.identifier.hkuros184816en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952897782&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume148en_HK
dc.identifier.issue1en_HK
dc.identifier.spage48en_HK
dc.identifier.epage52en_HK
dc.identifier.isiWOS:000288489300016-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridLong, MJ=37085444400en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridXu, L=7404744449en_HK
dc.identifier.scopusauthoridZhang, WS=13410704100en_HK
dc.identifier.scopusauthoridLin, JM=35409737900en_HK
dc.identifier.scopusauthoridOu, JP=37085436300en_HK
dc.identifier.scopusauthoridCheng, KK=7402997800en_HK
dc.identifier.citeulike6255513-

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