File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Annexin A1 expression in atherosclerotic carotid plaques and its relationship with plaque characteristics

TitleAnnexin A1 expression in atherosclerotic carotid plaques and its relationship with plaque characteristics
Authors
KeywordsAnnexin A1
Atherosclerosis
Carotid plaques
Plaque characteristics
Issue Date2011
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejvs
Citation
European Journal Of Vascular And Endovascular Surgery, 2011, v. 41 n. 3, p. 364-371 How to Cite?
AbstractObjective: Annexin A1, a calcium and phospholipid-binding protein, is an important endogenous modulator of inflammation. Whether this regulatory role extends to atherosclerosis is unknown. The aim of this study is to investigate the genetic and protein expression of Annexin A1 in carotid endarterectomy specimens from patients with significant carotid stenosis. Materials and methods: The echogenicity of atherosclerotic plaques was determined by ultrasound prior to carotid endarterectomy (CEA) in 34 consecutively recruited patients with carotid stenosis exceeding 70%. The Annexin A1 messenger RNA and protein expression of the corresponding plaques obtained from those patients were analyzed by reverse transcriptase polymerase chain reaction (RT-PCR) and the immunohistochemical method respectively. Results were analyzed with respect to plaque characteristics and symptomatic disease. Results: There were 25 males and 9 females, with a mean age of 68.8. Ten patients were asymptomatic. The symptomatic patients plaques were more echolucent (mean grey scale median (GSM) of 103) than those of asymptomatic patients (mean GSM = 126, p = 0.022). The Annexin A1 protein was constitutively expressed in all plaques, and Annexin A1 gene expression was statistically higher in patients with asymptomatic disease compared with those with neurological symptoms (87 ± 4% vs. 42 ± 6.2%; p < 0.001, unpaired t-test). The GSM score was positively correlated with Annexin A1 levels in patients with high-grade carotid artery stenosis (r = 0.501, p = 0.009). Conclusions: This is the first study to suggest that high Annexin A1 expression may have a stabilising effect in asymptomatic patients with less echolucent atherosclerotic plaques. Since atherosclerosis is an inflammatory process, we further postulate that Annexin A1 may play an essential role in preventing plaque complications or disease progression. © 2010 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/133330
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.723
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheuk, BLYen_HK
dc.contributor.authorCheng, SWKen_HK
dc.date.accessioned2011-05-11T08:32:00Z-
dc.date.available2011-05-11T08:32:00Z-
dc.date.issued2011en_HK
dc.identifier.citationEuropean Journal Of Vascular And Endovascular Surgery, 2011, v. 41 n. 3, p. 364-371en_HK
dc.identifier.issn1078-5884en_HK
dc.identifier.urihttp://hdl.handle.net/10722/133330-
dc.description.abstractObjective: Annexin A1, a calcium and phospholipid-binding protein, is an important endogenous modulator of inflammation. Whether this regulatory role extends to atherosclerosis is unknown. The aim of this study is to investigate the genetic and protein expression of Annexin A1 in carotid endarterectomy specimens from patients with significant carotid stenosis. Materials and methods: The echogenicity of atherosclerotic plaques was determined by ultrasound prior to carotid endarterectomy (CEA) in 34 consecutively recruited patients with carotid stenosis exceeding 70%. The Annexin A1 messenger RNA and protein expression of the corresponding plaques obtained from those patients were analyzed by reverse transcriptase polymerase chain reaction (RT-PCR) and the immunohistochemical method respectively. Results were analyzed with respect to plaque characteristics and symptomatic disease. Results: There were 25 males and 9 females, with a mean age of 68.8. Ten patients were asymptomatic. The symptomatic patients plaques were more echolucent (mean grey scale median (GSM) of 103) than those of asymptomatic patients (mean GSM = 126, p = 0.022). The Annexin A1 protein was constitutively expressed in all plaques, and Annexin A1 gene expression was statistically higher in patients with asymptomatic disease compared with those with neurological symptoms (87 ± 4% vs. 42 ± 6.2%; p < 0.001, unpaired t-test). The GSM score was positively correlated with Annexin A1 levels in patients with high-grade carotid artery stenosis (r = 0.501, p = 0.009). Conclusions: This is the first study to suggest that high Annexin A1 expression may have a stabilising effect in asymptomatic patients with less echolucent atherosclerotic plaques. Since atherosclerosis is an inflammatory process, we further postulate that Annexin A1 may play an essential role in preventing plaque complications or disease progression. © 2010 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejvsen_HK
dc.relation.ispartofEuropean Journal of Vascular and Endovascular Surgeryen_HK
dc.subjectAnnexin A1en_HK
dc.subjectAtherosclerosisen_HK
dc.subjectCarotid plaquesen_HK
dc.subjectPlaque characteristicsen_HK
dc.titleAnnexin A1 expression in atherosclerotic carotid plaques and its relationship with plaque characteristicsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1078-5884&volume=41&issue=3&spage=364&epage=371&date=2011&atitle=Annexin+A1+expression+in+atherosclerotic+carotid+plaques+and+its+relationship+with+plaque+characteristics-
dc.identifier.emailCheuk, BLY: bernice@hku.hken_HK
dc.identifier.emailCheng, SWK: wkcheng@hkucc.hku.hken_HK
dc.identifier.authorityCheuk, BLY=rp01671en_HK
dc.identifier.authorityCheng, SWK=rp00374en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejvs.2010.11.021en_HK
dc.identifier.pmid21195640-
dc.identifier.scopuseid_2-s2.0-79951767687en_HK
dc.identifier.hkuros185020en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79951767687&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue3en_HK
dc.identifier.spage364en_HK
dc.identifier.epage371en_HK
dc.identifier.isiWOS:000288728400014-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheuk, BLY=7801343617en_HK
dc.identifier.scopusauthoridCheng, SWK=7404684779en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats