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Article: Grafted tendon healing in tibial tunnel is inferior to healing in femoral tunnel after anterior cruciate ligament reconstruction: a histomorphometric study in rabbits

TitleGrafted tendon healing in tibial tunnel is inferior to healing in femoral tunnel after anterior cruciate ligament reconstruction: a histomorphometric study in rabbits
Authors
Issue Date2010
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/arthro
Citation
Arthroscopy, 2010, v. 26 n. 1, p. 58-66 How to Cite?
AbstractPURPOSE: This study aimed to test whether graft healing in the tibial tunnel was inferior to that in the femoral tunnel after anterior cruciate ligament (ACL) reconstruction in rabbits. METHODS: Surgical reconstruction by use of the digital extensor tendon in the bone tunnel was performed in 18 rabbits. The rabbits were killed at weeks 2, 6, and 12 postoperatively, with 6 at each time point, for histologic examination. RESULTS: The transiently formed cartilaginous interface was gradually mineralized during re-establishment of direct tendon-to-bone integration, which was observed significantly less in the tibial tunnel than in the femoral tunnel (P < .05). The cell density of the graft was significantly lower in the tibial tunnel than that in the femoral tunnel at weeks 2 and 6 postoperatively (P < .05 for both). An increase in the immature type III collagen content was accompanied by a decrease in graft collagen fiber organization, with healing over time in both the femoral and tibial tunnels. The collagen fiber organization of the graft was significantly poorer in the tibial tunnel than that in the femoral tunnel at week 12 after surgery (P < .05). CONCLUSIONS: Grafted tendon healing in the tibial tunnel was inferior to that in the femoral tunnel at the tendon-to-bone interface and with regard to the grafted tendon within the bone tunnel after ACL reconstruction in rabbits. CLINICAL RELEVANCE: Future biopsy study is desirable to test whether this observation was valid clinically, which might provide a scientific basis for therapeutic targets to improve the outcome of ACL surgery.
Persistent Identifierhttp://hdl.handle.net/10722/133025
ISSN
2015 Impact Factor: 3.724
2015 SCImago Journal Rankings: 2.300
ISI Accession Number ID
Funding AgencyGrant Number
Research Grant Council, Hong Kong, China06-07 (CUHK4497/06M)
Funding Information:

Supported by the Research Grant Council Earmarked Grants 06-07 (CUHK4497/06M), Hong Kong, China. The authors report no conflict of interest.

 

DC FieldValueLanguage
dc.contributor.authorWen, CY-
dc.contributor.authorQin, L-
dc.contributor.authorLee, KM-
dc.contributor.authorWong, MWN-
dc.contributor.authorChan, KM-
dc.date.accessioned2011-04-18T04:37:04Z-
dc.date.available2011-04-18T04:37:04Z-
dc.date.issued2010-
dc.identifier.citationArthroscopy, 2010, v. 26 n. 1, p. 58-66-
dc.identifier.issn0749-8063-
dc.identifier.urihttp://hdl.handle.net/10722/133025-
dc.description.abstractPURPOSE: This study aimed to test whether graft healing in the tibial tunnel was inferior to that in the femoral tunnel after anterior cruciate ligament (ACL) reconstruction in rabbits. METHODS: Surgical reconstruction by use of the digital extensor tendon in the bone tunnel was performed in 18 rabbits. The rabbits were killed at weeks 2, 6, and 12 postoperatively, with 6 at each time point, for histologic examination. RESULTS: The transiently formed cartilaginous interface was gradually mineralized during re-establishment of direct tendon-to-bone integration, which was observed significantly less in the tibial tunnel than in the femoral tunnel (P < .05). The cell density of the graft was significantly lower in the tibial tunnel than that in the femoral tunnel at weeks 2 and 6 postoperatively (P < .05 for both). An increase in the immature type III collagen content was accompanied by a decrease in graft collagen fiber organization, with healing over time in both the femoral and tibial tunnels. The collagen fiber organization of the graft was significantly poorer in the tibial tunnel than that in the femoral tunnel at week 12 after surgery (P < .05). CONCLUSIONS: Grafted tendon healing in the tibial tunnel was inferior to that in the femoral tunnel at the tendon-to-bone interface and with regard to the grafted tendon within the bone tunnel after ACL reconstruction in rabbits. CLINICAL RELEVANCE: Future biopsy study is desirable to test whether this observation was valid clinically, which might provide a scientific basis for therapeutic targets to improve the outcome of ACL surgery.-
dc.languageeng-
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/arthro-
dc.relation.ispartofArthroscopy-
dc.subject.meshAnterior Cruciate Ligament - pathology - surgery-
dc.subject.meshFemur - pathology - physiopathology-
dc.subject.meshPatellar Ligament - transplantation-
dc.subject.meshReconstructive Surgical Procedures - methods-
dc.subject.meshTendons - transplantation-
dc.titleGrafted tendon healing in tibial tunnel is inferior to healing in femoral tunnel after anterior cruciate ligament reconstruction: a histomorphometric study in rabbitsen_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0749-8063&volume=26&issue=1&spage=58&epage=66&date=2010&atitle=Grafted+tendon+healing+in+tibial+tunnel+is+inferior+to+healing+in+femoral+tunnel+after+anterior+cruciate+ligament+reconstruction:+a+histomorphometric+study+in+rabbits-
dc.identifier.emailWen, CY: paulwen@hku.hk, wenchunyi@gmail.com-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.arthro.2009.06.025-
dc.identifier.pmid20117628-
dc.identifier.scopuseid_2-s2.0-72649086598-
dc.identifier.hkuros174670-
dc.identifier.volume26-
dc.identifier.issue1-
dc.identifier.spage58-
dc.identifier.epage66-
dc.identifier.isiWOS:000274299700009-

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