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- Publisher Website: 10.1111/j.1365-2125.2008.03289.x
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- PMID: 19032726
- WOS: WOS:000261133400012
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Article: Population pharmacokinetics of oral diclofenac for acute pain in children
Title | Population pharmacokinetics of oral diclofenac for acute pain in children | ||||
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Authors | |||||
Keywords | Acute pain Children Diclofenac NONMEM Population pharmacokinetics | ||||
Issue Date | 2008 | ||||
Publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJCP | ||||
Citation | British Journal Of Clinical Pharmacology, 2008, v. 66 n. 6, p. 846-853 How to Cite? | ||||
Abstract | AIMS: To develop a population pharmacokinetic model for a new diclofenac suspension (50 mg 5 ml -1) in adult volunteers and paediatric patients, and recommend a dose for acute pain in children. METHODS: Blood samples were drawn at the start and end of surgery, and on removal of the venous cannula from 70 children (aged 1 to 12 years, weight 9 to 37 kg) who received a preoperative oral 1 mg kg -1 dose; these were pooled with rich (14 post-dose samples) data from 30 adult volunteers. Population pharmacokinetic modelling was undertaken with NONMEM. The optimum adult dose of diclofenac for acute pain is 50 mg. Simulation from the final model was performed to predict a paediatric dose to achieve a similar AUC to 50 mg in adults. RESULTS: A total of 558 serum diclofenac concentrations from 100 subjects was used in the pooled analysis. A single disposition compartment model with first order elimination and dual absorption compartments was used. The estimates of CL/F and V D/F were 53.98 l h -1 70 kg -1 and 4.84 l 70 kg -1 respectively. Allometric size models appeared to predict adequately changes in CL and V D with age. Of the simulated doses investigated, 1 mg kg -1 gave paediatric AUC (0,12 h) to adult 50 mg AUC (0,12 h) ratios of 1.00, 1.08 and 1.18 for ages 1-3, 4-6 and 7-12 years respectively. CONCLUSIONS: This study has shown 1 mg kg -1 diclofenac to produce similar exposure in children aged 1 to 12 years as 50 mg in adults, and is acceptable for clinical practice; patients are unlikely to obtain further benefit from higher doses. © 2008 The Authors. | ||||
Persistent Identifier | http://hdl.handle.net/10722/132929 | ||||
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 1.046 | ||||
PubMed Central ID | |||||
ISI Accession Number ID |
Funding Information: Competing interests: JFS received a PhD studentship sponsored by Rosemont Pharmaceuticals Ltd. | ||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Standing, JF | en_HK |
dc.contributor.author | Howard, RF | en_HK |
dc.contributor.author | Johnson, A | en_HK |
dc.contributor.author | Savage, I | en_HK |
dc.contributor.author | Wong, ICK | en_HK |
dc.date.accessioned | 2011-04-04T07:58:02Z | - |
dc.date.available | 2011-04-04T07:58:02Z | - |
dc.date.issued | 2008 | en_HK |
dc.identifier.citation | British Journal Of Clinical Pharmacology, 2008, v. 66 n. 6, p. 846-853 | en_HK |
dc.identifier.issn | 0306-5251 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/132929 | - |
dc.description.abstract | AIMS: To develop a population pharmacokinetic model for a new diclofenac suspension (50 mg 5 ml -1) in adult volunteers and paediatric patients, and recommend a dose for acute pain in children. METHODS: Blood samples were drawn at the start and end of surgery, and on removal of the venous cannula from 70 children (aged 1 to 12 years, weight 9 to 37 kg) who received a preoperative oral 1 mg kg -1 dose; these were pooled with rich (14 post-dose samples) data from 30 adult volunteers. Population pharmacokinetic modelling was undertaken with NONMEM. The optimum adult dose of diclofenac for acute pain is 50 mg. Simulation from the final model was performed to predict a paediatric dose to achieve a similar AUC to 50 mg in adults. RESULTS: A total of 558 serum diclofenac concentrations from 100 subjects was used in the pooled analysis. A single disposition compartment model with first order elimination and dual absorption compartments was used. The estimates of CL/F and V D/F were 53.98 l h -1 70 kg -1 and 4.84 l 70 kg -1 respectively. Allometric size models appeared to predict adequately changes in CL and V D with age. Of the simulated doses investigated, 1 mg kg -1 gave paediatric AUC (0,12 h) to adult 50 mg AUC (0,12 h) ratios of 1.00, 1.08 and 1.18 for ages 1-3, 4-6 and 7-12 years respectively. CONCLUSIONS: This study has shown 1 mg kg -1 diclofenac to produce similar exposure in children aged 1 to 12 years as 50 mg in adults, and is acceptable for clinical practice; patients are unlikely to obtain further benefit from higher doses. © 2008 The Authors. | en_HK |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJCP | en_HK |
dc.relation.ispartof | British Journal of Clinical Pharmacology | en_HK |
dc.subject | Acute pain | en_HK |
dc.subject | Children | en_HK |
dc.subject | Diclofenac | en_HK |
dc.subject | NONMEM | en_HK |
dc.subject | Population pharmacokinetics | en_HK |
dc.title | Population pharmacokinetics of oral diclofenac for acute pain in children | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Wong, ICK: wongick@hku.hk | en_HK |
dc.identifier.authority | Wong, ICK=rp01480 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1365-2125.2008.03289.x | en_HK |
dc.identifier.pmid | 19032726 | - |
dc.identifier.pmcid | PMC2675780 | - |
dc.identifier.scopus | eid_2-s2.0-56549122658 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-56549122658&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 66 | en_HK |
dc.identifier.issue | 6 | en_HK |
dc.identifier.spage | 846 | en_HK |
dc.identifier.epage | 853 | en_HK |
dc.identifier.eissn | 1365-2125 | - |
dc.identifier.isi | WOS:000261133400012 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Standing, JF=8702431000 | en_HK |
dc.identifier.scopusauthorid | Howard, RF=7403674211 | en_HK |
dc.identifier.scopusauthorid | Johnson, A=7410015511 | en_HK |
dc.identifier.scopusauthorid | Savage, I=7004074225 | en_HK |
dc.identifier.scopusauthorid | Wong, ICK=7102513915 | en_HK |
dc.identifier.citeulike | 3689584 | - |
dc.identifier.issnl | 0306-5251 | - |