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Article: Minitablets: New modality to deliver medicines to preschool-aged children

TitleMinitablets: New modality to deliver medicines to preschool-aged children
Authors
KeywordsMinitablets
Oral dosage form
Issue Date2009
PublisherAmerican Academy of Pediatrics. The Journal's web site is located at http://pediatrics.aappublications.org/
Citation
Pediatrics, 2009, v. 123 n. 2, p. e235-e238 How to Cite?
AbstractOBJECTIVE. The goal was to assess the acceptability and suitability of placebo minitablets for preschool-aged children. METHODS. One hundred children 2 to 6 years of age were recruited from a major London hospital. How to swallow the minitablet was discussed with the child, and chewing was discouraged. The parents were asked to administer 1 minitablet (placebo, 3-mm diameter) to the child. The outcomes were recorded as (1) swallowed, (2) chewed, (3) spat out, or (4) refused to take. RESULTS. Of the youngest children (2 years of age), almost one half (46%) swallowed the minitablet. The proportion increased to 53% for children 3 years of age. Children ≥4 years of age were more likely to swallow the minitablet than not to swallow the minitablet, with 85% of 5-year-old children swallowing the minitablet. The ability to swallow the minitablet was not affected by gender. CONCLUSIONS. This study demonstrated the potential to use minitablets for the treatment of preschool-aged children and suggests that minitablets can be used as a potential new formulation for children in this age range. Copyright © 2009 by the American Academy of Pediatrics.
Persistent Identifierhttp://hdl.handle.net/10722/132890
ISSN
2015 Impact Factor: 5.196
2015 SCImago Journal Rankings: 3.226
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorThomson, SAen_HK
dc.contributor.authorTuleu, Cen_HK
dc.contributor.authorWong, ICKen_HK
dc.contributor.authorKeady, Sen_HK
dc.contributor.authorPitt, KGen_HK
dc.contributor.authorSutcliffe, AGen_HK
dc.date.accessioned2011-04-04T07:57:49Z-
dc.date.available2011-04-04T07:57:49Z-
dc.date.issued2009en_HK
dc.identifier.citationPediatrics, 2009, v. 123 n. 2, p. e235-e238en_HK
dc.identifier.issn0031-4005en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132890-
dc.description.abstractOBJECTIVE. The goal was to assess the acceptability and suitability of placebo minitablets for preschool-aged children. METHODS. One hundred children 2 to 6 years of age were recruited from a major London hospital. How to swallow the minitablet was discussed with the child, and chewing was discouraged. The parents were asked to administer 1 minitablet (placebo, 3-mm diameter) to the child. The outcomes were recorded as (1) swallowed, (2) chewed, (3) spat out, or (4) refused to take. RESULTS. Of the youngest children (2 years of age), almost one half (46%) swallowed the minitablet. The proportion increased to 53% for children 3 years of age. Children ≥4 years of age were more likely to swallow the minitablet than not to swallow the minitablet, with 85% of 5-year-old children swallowing the minitablet. The ability to swallow the minitablet was not affected by gender. CONCLUSIONS. This study demonstrated the potential to use minitablets for the treatment of preschool-aged children and suggests that minitablets can be used as a potential new formulation for children in this age range. Copyright © 2009 by the American Academy of Pediatrics.en_HK
dc.languageengen_US
dc.publisherAmerican Academy of Pediatrics. The Journal's web site is located at http://pediatrics.aappublications.org/en_HK
dc.relation.ispartofPediatricsen_HK
dc.subjectMinitabletsen_HK
dc.subjectOral dosage formen_HK
dc.titleMinitablets: New modality to deliver medicines to preschool-aged childrenen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, ICK: wongick@hku.hken_HK
dc.identifier.authorityWong, ICK=rp01480en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1542/peds.2008-2059en_HK
dc.identifier.pmid19171575-
dc.identifier.scopuseid_2-s2.0-61549095823en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-61549095823&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume123en_HK
dc.identifier.issue2en_HK
dc.identifier.spagee235en_HK
dc.identifier.epagee238en_HK
dc.identifier.eissn1098-4275-
dc.identifier.isiWOS:000262678700055-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridThomson, SA=36848726700en_HK
dc.identifier.scopusauthoridTuleu, C=8446290500en_HK
dc.identifier.scopusauthoridWong, ICK=7102513915en_HK
dc.identifier.scopusauthoridKeady, S=6602621384en_HK
dc.identifier.scopusauthoridPitt, KG=14424435500en_HK
dc.identifier.scopusauthoridSutcliffe, AG=7005644774en_HK

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