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Article: National study of extemporaneous preparations in English paediatric hospital pharmacies

TitleNational study of extemporaneous preparations in English paediatric hospital pharmacies
Authors
KeywordsExtemporaneous preparations
Paediatric hospitals
Issue Date2004
Citation
Paediatric And Perinatal Drug Therapy, 2004, v. 6 n. 2, p. 75-80 How to Cite?
AbstractBackground: Licensed formulations are not always suitable for young children. Pharmacy departments at paediatric hospitals produce in-house extemporaneous preparations for children. The Department of Health in England has recently announced a major investment in hospital production units to improve the manufacturing facilities. However, there is no published systematic study to investigate the extemporaneous production activities in paediatric hospitals in England in order to support future planning. Objectives: To identify the methods, frequencies and types of medications prepared extemporaneously in the pharmacies of paediatric hospitals in England and the percentage of above preparations that were available from specials manufacturers. Methods: A national survey of in-house extemporaneous preparations by the seven paediatric hospitals in England was conducted over a period of 12 months. The drug, type of product and frequency of each preparation were recorded, and analysed. Results: All seven hospitals (100%) replied to our survey. On average, 1.5 items per day per hospital were manufactured. The top 20 drugs represented more than 58% of the workload, indicating the repetitive nature of the work. 76% of the final preparations were in liquid dosage forms. Only 27% of medicines extemporaneously prepared were unlicensed chemical entities. However, 50% of the extemporaneous products made could be provided by specials manufacturers. Conclusions: The extent of extemporaneous dispensing in paediatric pharmacies was lower than anticipated. The top 20 commonly used drugs (58% of the workload) could be produced by licensed units or specials manufacturers to reduce the risk of production errors. As the diversity of strengths of the same medicines that are produced in different centres creates opportunities for medication errors, the idea of establishing a national extemporaneous formulary to standardise the strengths and presentations should be explored.
Persistent Identifierhttp://hdl.handle.net/10722/132888
ISSN
2011 SCImago Journal Rankings: 0.104
References

 

DC FieldValueLanguage
dc.contributor.authorYeung, VWen_HK
dc.contributor.authorTuleu, CLCen_HK
dc.contributor.authorWong, ICKen_HK
dc.date.accessioned2011-04-04T07:57:48Z-
dc.date.available2011-04-04T07:57:48Z-
dc.date.issued2004en_HK
dc.identifier.citationPaediatric And Perinatal Drug Therapy, 2004, v. 6 n. 2, p. 75-80en_HK
dc.identifier.issn1463-0095en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132888-
dc.description.abstractBackground: Licensed formulations are not always suitable for young children. Pharmacy departments at paediatric hospitals produce in-house extemporaneous preparations for children. The Department of Health in England has recently announced a major investment in hospital production units to improve the manufacturing facilities. However, there is no published systematic study to investigate the extemporaneous production activities in paediatric hospitals in England in order to support future planning. Objectives: To identify the methods, frequencies and types of medications prepared extemporaneously in the pharmacies of paediatric hospitals in England and the percentage of above preparations that were available from specials manufacturers. Methods: A national survey of in-house extemporaneous preparations by the seven paediatric hospitals in England was conducted over a period of 12 months. The drug, type of product and frequency of each preparation were recorded, and analysed. Results: All seven hospitals (100%) replied to our survey. On average, 1.5 items per day per hospital were manufactured. The top 20 drugs represented more than 58% of the workload, indicating the repetitive nature of the work. 76% of the final preparations were in liquid dosage forms. Only 27% of medicines extemporaneously prepared were unlicensed chemical entities. However, 50% of the extemporaneous products made could be provided by specials manufacturers. Conclusions: The extent of extemporaneous dispensing in paediatric pharmacies was lower than anticipated. The top 20 commonly used drugs (58% of the workload) could be produced by licensed units or specials manufacturers to reduce the risk of production errors. As the diversity of strengths of the same medicines that are produced in different centres creates opportunities for medication errors, the idea of establishing a national extemporaneous formulary to standardise the strengths and presentations should be explored.en_HK
dc.languageengen_US
dc.relation.ispartofPaediatric and Perinatal Drug Therapyen_HK
dc.subjectExtemporaneous preparationsen_HK
dc.subjectPaediatric hospitalsen_HK
dc.titleNational study of extemporaneous preparations in English paediatric hospital pharmaciesen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, ICK: wongick@hku.hken_HK
dc.identifier.authorityWong, ICK=rp01480en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1185/146300904X12668en_HK
dc.identifier.scopuseid_2-s2.0-15944377425en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-15944377425&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue2en_HK
dc.identifier.spage75en_HK
dc.identifier.epage80en_HK
dc.identifier.scopusauthoridYeung, VW=9841023300en_HK
dc.identifier.scopusauthoridTuleu, CLC=8446290500en_HK
dc.identifier.scopusauthoridWong, ICK=7102513915en_HK
dc.identifier.citeulike122550-

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