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Article: Epidemiologic features of antipsychotic prescribing to children and adolescents in primary care in the United Kingdom

TitleEpidemiologic features of antipsychotic prescribing to children and adolescents in primary care in the United Kingdom
Authors
KeywordsAntipsychotics
Drug utilization
Pediatric
Pharmacoepidemiology
Issue Date2008
PublisherAmerican Academy of Pediatrics. The Journal's web site is located at http://pediatrics.aappublications.org/
Citation
Pediatrics, 2008, v. 121 n. 5, p. 1002-1009 How to Cite?
AbstractOBJECTIVE. The goal was to investigate the epidemiologic features of antipsychotic prescribing to children and adolescents in general practice in the United Kingdom. METHODS. A total of 384 participating general practices from the United Kingdom General Practice Research Database were used to identify patients 0 to 18 years of age who were prescribed ≥1 antipsychotic medication between January 1, 1992, and December 31, 2005. Annual age-specific prevalences and incidences of antipsychotic prescribing were calculated. RESULTS. The overall prevalence of use of all antipsychotics increased from 1992 (0.39 users per 1000 patient-years) to 2005 (0.77 users per 1000 patient-years). The prescribing prevalence for patients 7 to 12 years of age almost tripled between 1992 (0.23 users per 1000 patient-years) and 2005 (0.61 users per 1000 patient-years). Atypical antipsychotic prescribing increased 60-fold from 1994 (0.01 users per 1000 patient-years) to 2005 (0.61 users per 1000 patient-years). However, typical antipsychotic prescribing decreased significantly from 2000 (0.44 users per 1000 patient- years) to 2005 (0.18 users per 1000 patient-years). The incidences for typical and atypical antipsychotics showed trends similar to those of the respective prevalences. However, the overall incidence (number of new starters) for all antipsychotics was relatively stable between 1992 and 2005, which suggests that patients remain on treatment longer. CONCLUSIONS. The overall prevalence of antipsychotics almost doubled between 1992 and 2005;however, the rate of increase was much lower than the reported figures in the United States. The prescribing of atypical antipsychotic drugs has increased despite the lack of conclusive evidence showing their superiority over older conventional antipsychotics. Additional investigation is required to evaluate their efficacy and safety in children and adolescents. Copyright © 2008 by the American Academy of Pediatrics.
Persistent Identifierhttp://hdl.handle.net/10722/132860
ISSN
2015 Impact Factor: 5.196
2015 SCImago Journal Rankings: 3.226
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRani, Fen_HK
dc.contributor.authorMurray, MLen_HK
dc.contributor.authorByrne, PJen_HK
dc.contributor.authorWong, ICKen_HK
dc.date.accessioned2011-04-04T07:57:38Z-
dc.date.available2011-04-04T07:57:38Z-
dc.date.issued2008en_HK
dc.identifier.citationPediatrics, 2008, v. 121 n. 5, p. 1002-1009en_HK
dc.identifier.issn0031-4005en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132860-
dc.description.abstractOBJECTIVE. The goal was to investigate the epidemiologic features of antipsychotic prescribing to children and adolescents in general practice in the United Kingdom. METHODS. A total of 384 participating general practices from the United Kingdom General Practice Research Database were used to identify patients 0 to 18 years of age who were prescribed ≥1 antipsychotic medication between January 1, 1992, and December 31, 2005. Annual age-specific prevalences and incidences of antipsychotic prescribing were calculated. RESULTS. The overall prevalence of use of all antipsychotics increased from 1992 (0.39 users per 1000 patient-years) to 2005 (0.77 users per 1000 patient-years). The prescribing prevalence for patients 7 to 12 years of age almost tripled between 1992 (0.23 users per 1000 patient-years) and 2005 (0.61 users per 1000 patient-years). Atypical antipsychotic prescribing increased 60-fold from 1994 (0.01 users per 1000 patient-years) to 2005 (0.61 users per 1000 patient-years). However, typical antipsychotic prescribing decreased significantly from 2000 (0.44 users per 1000 patient- years) to 2005 (0.18 users per 1000 patient-years). The incidences for typical and atypical antipsychotics showed trends similar to those of the respective prevalences. However, the overall incidence (number of new starters) for all antipsychotics was relatively stable between 1992 and 2005, which suggests that patients remain on treatment longer. CONCLUSIONS. The overall prevalence of antipsychotics almost doubled between 1992 and 2005;however, the rate of increase was much lower than the reported figures in the United States. The prescribing of atypical antipsychotic drugs has increased despite the lack of conclusive evidence showing their superiority over older conventional antipsychotics. Additional investigation is required to evaluate their efficacy and safety in children and adolescents. Copyright © 2008 by the American Academy of Pediatrics.en_HK
dc.languageengen_US
dc.publisherAmerican Academy of Pediatrics. The Journal's web site is located at http://pediatrics.aappublications.org/en_HK
dc.relation.ispartofPediatricsen_HK
dc.subjectAntipsychoticsen_HK
dc.subjectDrug utilizationen_HK
dc.subjectPediatricen_HK
dc.subjectPharmacoepidemiologyen_HK
dc.titleEpidemiologic features of antipsychotic prescribing to children and adolescents in primary care in the United Kingdomen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, ICK: wongick@hku.hken_HK
dc.identifier.authorityWong, ICK=rp01480en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1542/peds.2007-2008en_HK
dc.identifier.pmid18450906en_HK
dc.identifier.scopuseid_2-s2.0-44449097249en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-44449097249&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume121en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1002en_HK
dc.identifier.epage1009en_HK
dc.identifier.eissn1098-4275-
dc.identifier.isiWOS:000255501900018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRani, F=24336008200en_HK
dc.identifier.scopusauthoridMurray, ML=7403583537en_HK
dc.identifier.scopusauthoridByrne, PJ=36149774000en_HK
dc.identifier.scopusauthoridWong, ICK=7102513915en_HK

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