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Article: Administration of melatonin mixed with soft food and liquids for children with neurodevelopmental difficulties

TitleAdministration of melatonin mixed with soft food and liquids for children with neurodevelopmental difficulties
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2008
PublisherMac Keith Press. The Journal's web site is located at http://www.mackeith.co.uk/journal.html
Citation
Developmental Medicine And Child Neurology, 2008, v. 50 n. 11, p. 845-849 How to Cite?
AbstractIt is sometimes necessary for the contents of medication capsules to be mixed with certain foods and drinks because children are not always able to swallow the capsules. The compatibility and short-term stability (6h) of melatonin capsules mixed in a variety of liquids and foodstuffs (water, orange juice, semi-skimmed milk, strawberry yogurt, and strawberry jam) were analyzed for degradation. Extraction of melatonin from these common administration vehicles and an analytical assay for the drug and its potential degradation products were developed and validated. The results showed good recovery of melatonin from low- and high-strength capsules for all administration vehicles (between 89% minimum and 111% maximum). The drug was found to be stable in the common liquids and foods tested for up to 6 hours at room temperature (no degradation peak); hence it is unlikely to compromise the results of the Use of Melatonin in Children with Neurodevelopmental Disorders and Impaired Sleep trial. © 2008 Mac Keith Press.
Persistent Identifierhttp://hdl.handle.net/10722/132859
ISSN
2015 Impact Factor: 3.615
2015 SCImago Journal Rankings: 1.636
ISI Accession Number ID
Funding AgencyGrant Number
Health and Technology Assessment
Funding Information:

We thank: John Barber, Alliance Pharmaceuticals Ltd, for providing the melatonin capsules and advice in melatonin dosing; Penn Pharmaceutical Services Ltd for advice in melatonin analysis; John Hughes at Biomedical Ltd for help with statistics; and the Health and Technology Assessment for funding the MENDS trial.

References

 

DC FieldValueLanguage
dc.contributor.authorShah, Ten_HK
dc.contributor.authorTse, APYen_HK
dc.contributor.authorGill, Hen_HK
dc.contributor.authorWong, ICKen_HK
dc.contributor.authorSutcliffe, Aen_HK
dc.contributor.authorGringras, Pen_HK
dc.contributor.authorAppleton, Ren_HK
dc.contributor.authorTuleu, Cen_HK
dc.date.accessioned2011-04-04T07:57:37Z-
dc.date.available2011-04-04T07:57:37Z-
dc.date.issued2008en_HK
dc.identifier.citationDevelopmental Medicine And Child Neurology, 2008, v. 50 n. 11, p. 845-849en_HK
dc.identifier.issn0012-1622en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132859-
dc.description.abstractIt is sometimes necessary for the contents of medication capsules to be mixed with certain foods and drinks because children are not always able to swallow the capsules. The compatibility and short-term stability (6h) of melatonin capsules mixed in a variety of liquids and foodstuffs (water, orange juice, semi-skimmed milk, strawberry yogurt, and strawberry jam) were analyzed for degradation. Extraction of melatonin from these common administration vehicles and an analytical assay for the drug and its potential degradation products were developed and validated. The results showed good recovery of melatonin from low- and high-strength capsules for all administration vehicles (between 89% minimum and 111% maximum). The drug was found to be stable in the common liquids and foods tested for up to 6 hours at room temperature (no degradation peak); hence it is unlikely to compromise the results of the Use of Melatonin in Children with Neurodevelopmental Disorders and Impaired Sleep trial. © 2008 Mac Keith Press.en_HK
dc.languageengen_US
dc.publisherMac Keith Press. The Journal's web site is located at http://www.mackeith.co.uk/journal.htmlen_HK
dc.relation.ispartofDevelopmental Medicine and Child Neurologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleAdministration of melatonin mixed with soft food and liquids for children with neurodevelopmental difficultiesen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, ICK: wongick@hku.hken_HK
dc.identifier.authorityWong, ICK=rp01480en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1469-8749.2008.03092.xen_HK
dc.identifier.pmid18754762-
dc.identifier.scopuseid_2-s2.0-54249146901en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-54249146901&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue11en_HK
dc.identifier.spage845en_HK
dc.identifier.epage849en_HK
dc.identifier.eissn1469-8749-
dc.identifier.isiWOS:000261118800012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridShah, T=8508694300en_HK
dc.identifier.scopusauthoridTse, APY=25522646100en_HK
dc.identifier.scopusauthoridGill, H=14030206600en_HK
dc.identifier.scopusauthoridWong, ICK=7102513915en_HK
dc.identifier.scopusauthoridSutcliffe, A=7005644774en_HK
dc.identifier.scopusauthoridGringras, P=6602839332en_HK
dc.identifier.scopusauthoridAppleton, R=7006707014en_HK
dc.identifier.scopusauthoridTuleu, C=8446290500en_HK

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