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Article: Repeat-screening colonoscopy 5 years after normal baseline-screening colonoscopy in average-risk chinese: A prospective study

TitleRepeat-screening colonoscopy 5 years after normal baseline-screening colonoscopy in average-risk chinese: A prospective study
Authors
KeywordsReferences (29) View In Table Layout
Issue Date2009
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
Citation
American Journal Of Gastroenterology, 2009, v. 104 n. 8, p. 2028-2034 How to Cite?
AbstractOBJECTIVES: Although colonoscopy is considered the most accurate screening tool for colorectal neoplasm, the optimal interval of repeating a screening colonoscopy, particularly in average-risk subjects after a negative colonoscopy, is poorly defined. We determine the 5-year risk of advanced neoplasia on rescreening colonoscopy in a cohort of average-risk Chinese subjects.METHODS:We invited a cohort of asymptomatic average-risk Chinese subjects (aged 55-75 years) who were recruited in our previous screening colonoscopy studies to undergo a repeat colonoscopy at the end of 5 years. The rates of advanced colorectal neoplasia at the end of 5 years in these subjects were determined according to their baseline colonoscopy findings.RESULTS:A total of 511 of the 620 eligible subjects underwent repeat-screening colonoscopy at the end of 5 years. Among them, 401 subjects had no baseline neoplasia (370 with no baseline polyps and 31 with hyperplastic polyps). In subjects with no baseline polyp, 24.6% were found to have at least one adenoma and 1.4% had advanced neoplasia on rescreening. The number needed to rescreen for one advanced neoplasia in subjects with no baseline polyp was 74 (95% confidence interval (CI), 32-168). The prevalence of advanced neoplasia at 5 years in subjects with baseline-advanced neoplasia was 20.7% (relative risk 19.6; 95% CI, 5.2-74.1; vs. subjects with no baseline polyp). The presence of baseline-advanced neoplasia (odds ratio (OR) 13.1; 95% CI, 4.1-41.7) and age in years (OR 1.11; 95% CI, 1.01-1.22) are two independent factors for development of advanced neoplasia at 5 years.CONCLUSIONS:The risk of advanced neoplasia is sufficiently low 5 years after a normal screening colonoscopy in Chinese subjects. © 2009 by the American College of Gastroenterology.
Persistent Identifierhttp://hdl.handle.net/10722/132849
ISSN
2015 Impact Factor: 10.383
2015 SCImago Journal Rankings: 3.946
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, WKen_HK
dc.contributor.authorLau, JYen_HK
dc.contributor.authorSuen, BYen_HK
dc.contributor.authorWong, GLen_HK
dc.contributor.authorChow, DKen_HK
dc.contributor.authorLai, LHen_HK
dc.contributor.authorTo, KFen_HK
dc.contributor.authorYim, CKen_HK
dc.contributor.authorLee, ESen_HK
dc.contributor.authorTsoi, KKen_HK
dc.contributor.authorNg, SSen_HK
dc.contributor.authorSung, JJen_HK
dc.date.accessioned2011-04-04T07:57:25Z-
dc.date.available2011-04-04T07:57:25Z-
dc.date.issued2009en_HK
dc.identifier.citationAmerican Journal Of Gastroenterology, 2009, v. 104 n. 8, p. 2028-2034en_HK
dc.identifier.issn0002-9270en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132849-
dc.description.abstractOBJECTIVES: Although colonoscopy is considered the most accurate screening tool for colorectal neoplasm, the optimal interval of repeating a screening colonoscopy, particularly in average-risk subjects after a negative colonoscopy, is poorly defined. We determine the 5-year risk of advanced neoplasia on rescreening colonoscopy in a cohort of average-risk Chinese subjects.METHODS:We invited a cohort of asymptomatic average-risk Chinese subjects (aged 55-75 years) who were recruited in our previous screening colonoscopy studies to undergo a repeat colonoscopy at the end of 5 years. The rates of advanced colorectal neoplasia at the end of 5 years in these subjects were determined according to their baseline colonoscopy findings.RESULTS:A total of 511 of the 620 eligible subjects underwent repeat-screening colonoscopy at the end of 5 years. Among them, 401 subjects had no baseline neoplasia (370 with no baseline polyps and 31 with hyperplastic polyps). In subjects with no baseline polyp, 24.6% were found to have at least one adenoma and 1.4% had advanced neoplasia on rescreening. The number needed to rescreen for one advanced neoplasia in subjects with no baseline polyp was 74 (95% confidence interval (CI), 32-168). The prevalence of advanced neoplasia at 5 years in subjects with baseline-advanced neoplasia was 20.7% (relative risk 19.6; 95% CI, 5.2-74.1; vs. subjects with no baseline polyp). The presence of baseline-advanced neoplasia (odds ratio (OR) 13.1; 95% CI, 4.1-41.7) and age in years (OR 1.11; 95% CI, 1.01-1.22) are two independent factors for development of advanced neoplasia at 5 years.CONCLUSIONS:The risk of advanced neoplasia is sufficiently low 5 years after a normal screening colonoscopy in Chinese subjects. © 2009 by the American College of Gastroenterology.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.htmlen_HK
dc.relation.ispartofAmerican Journal of Gastroenterologyen_HK
dc.subjectReferences (29) View In Table Layouten_US
dc.subject.meshAgeden_HK
dc.subject.meshChinaen_HK
dc.subject.meshColonoscopy - statistics & numerical dataen_HK
dc.subject.meshColorectal Neoplasms - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMass Screening - statistics & numerical dataen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshTime Factorsen_HK
dc.titleRepeat-screening colonoscopy 5 years after normal baseline-screening colonoscopy in average-risk chinese: A prospective studyen_HK
dc.typeArticleen_HK
dc.identifier.emailLeung, WK:waikleung@hku.hken_HK
dc.identifier.authorityLeung, WK=rp01479en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/ajg.2009.202en_HK
dc.identifier.pmid19455125-
dc.identifier.scopuseid_2-s2.0-68349146553en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-68349146553&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume104en_HK
dc.identifier.issue8en_HK
dc.identifier.spage2028en_HK
dc.identifier.epage2034en_HK
dc.identifier.eissn1572-0241-
dc.identifier.isiWOS:000268965300019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLeung, WK=7201504523en_HK
dc.identifier.scopusauthoridLau, JY=34667994100en_HK
dc.identifier.scopusauthoridSuen, BY=6506058430en_HK
dc.identifier.scopusauthoridWong, GL=35277444000en_HK
dc.identifier.scopusauthoridChow, DK=36788133300en_HK
dc.identifier.scopusauthoridLai, LH=12759998700en_HK
dc.identifier.scopusauthoridTo, KF=7101911940en_HK
dc.identifier.scopusauthoridYim, CK=35277839800en_HK
dc.identifier.scopusauthoridLee, ES=35276871200en_HK
dc.identifier.scopusauthoridTsoi, KK=36869118100en_HK
dc.identifier.scopusauthoridNg, SS=35277520800en_HK
dc.identifier.scopusauthoridSung, JJ=36847007300en_HK

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