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Article: The gap junction: A channel for multiple functions?

TitleThe gap junction: A channel for multiple functions?
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1988
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ECI
Citation
European Journal Of Clinical Investigation, 1988, v. 18 n. 5, p. 444-453 How to Cite?
AbstractGap junctions are specialized membrane structures that enable the intercytoplasmic exchange of small molecules and ions between contacting cells. During the past decade, biophysical and structural analyses of the junctional channel have considerably increased our understanding of the pharmacological properties and gating mechanisms of gap junctions. Despite this impressive amount of work, until recently the physiological role of these ubiquitous intercellular pathways has remained speculative in most tissues. This review summarizes the most recent information obtained on the structure of the gap junction by molecular cloning of the major protein components and emphasizes the growing evidence for their functional role in adult tissues formed by highly differentiated secretory cells. The relevance of cell-to-cell coupling for the co-ordinated function of the exocrine and endocrine pancreas is discussed.
Persistent Identifierhttp://hdl.handle.net/10722/132782
ISSN
2015 Impact Factor: 2.687
2015 SCImago Journal Rankings: 1.255
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBruzzone, Ren_HK
dc.contributor.authorMeda, Pen_HK
dc.date.accessioned2011-03-28T09:28:56Z-
dc.date.available2011-03-28T09:28:56Z-
dc.date.issued1988en_HK
dc.identifier.citationEuropean Journal Of Clinical Investigation, 1988, v. 18 n. 5, p. 444-453en_HK
dc.identifier.issn0014-2972en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132782-
dc.description.abstractGap junctions are specialized membrane structures that enable the intercytoplasmic exchange of small molecules and ions between contacting cells. During the past decade, biophysical and structural analyses of the junctional channel have considerably increased our understanding of the pharmacological properties and gating mechanisms of gap junctions. Despite this impressive amount of work, until recently the physiological role of these ubiquitous intercellular pathways has remained speculative in most tissues. This review summarizes the most recent information obtained on the structure of the gap junction by molecular cloning of the major protein components and emphasizes the growing evidence for their functional role in adult tissues formed by highly differentiated secretory cells. The relevance of cell-to-cell coupling for the co-ordinated function of the exocrine and endocrine pancreas is discussed.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ECIen_HK
dc.relation.ispartofEuropean Journal of Clinical Investigationen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleThe gap junction: A channel for multiple functions?en_HK
dc.typeArticleen_HK
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_HK
dc.identifier.authorityBruzzone, R=rp01442en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2465898-
dc.identifier.scopuseid_2-s2.0-0023680541en_HK
dc.identifier.volume18en_HK
dc.identifier.issue5en_HK
dc.identifier.spage444en_HK
dc.identifier.epage453en_HK
dc.identifier.isiWOS:A1988Q453600003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridBruzzone, R=7006793327en_HK
dc.identifier.scopusauthoridMeda, P=7005822187en_HK

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