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Article: Measurement of cytosolic free Ca2+ in individual pancreatic acini

TitleMeasurement of cytosolic free Ca2+ in individual pancreatic acini
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1988
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
Citation
Febs Letters, 1988, v. 242 n. 1, p. 79-84 How to Cite?
AbstractThe kinetics of changes in cytosolic free Ca2+ ([Ca2+](i)) were determined in individual rat pancreatic acini by microfluorimetry. Three major findings are reported. First, at maximal stimulatory concentrations for amylase release, both caerulein and bombesin induced an initial rise in [Ca2+](i) followed by prolonged secondary oscillations of smaller amplitude. The latter effect was not observed with supramaximal doses of caerulein. Second, these cyclic changes were dependent, at least in part, on extracellular Ca2+. Finally, comparison of the threshold doses for [Ca2+](i) mobilization and enzyme discharge demonstrated that pathways independent of an elevation of [Ca2+](i) control the secretory activity of pancreatic acini at low, picomolar agonist concentrations.
Persistent Identifierhttp://hdl.handle.net/10722/132778
ISSN
2015 Impact Factor: 3.519
2015 SCImago Journal Rankings: 2.026
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPralong, WFen_HK
dc.contributor.authorWollheim, CBen_HK
dc.contributor.authorBruzzone, Ren_HK
dc.date.accessioned2011-03-28T09:28:55Z-
dc.date.available2011-03-28T09:28:55Z-
dc.date.issued1988en_HK
dc.identifier.citationFebs Letters, 1988, v. 242 n. 1, p. 79-84en_HK
dc.identifier.issn0014-5793en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132778-
dc.description.abstractThe kinetics of changes in cytosolic free Ca2+ ([Ca2+](i)) were determined in individual rat pancreatic acini by microfluorimetry. Three major findings are reported. First, at maximal stimulatory concentrations for amylase release, both caerulein and bombesin induced an initial rise in [Ca2+](i) followed by prolonged secondary oscillations of smaller amplitude. The latter effect was not observed with supramaximal doses of caerulein. Second, these cyclic changes were dependent, at least in part, on extracellular Ca2+. Finally, comparison of the threshold doses for [Ca2+](i) mobilization and enzyme discharge demonstrated that pathways independent of an elevation of [Ca2+](i) control the secretory activity of pancreatic acini at low, picomolar agonist concentrations.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febsleten_HK
dc.relation.ispartofFEBS Lettersen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleMeasurement of cytosolic free Ca2+ in individual pancreatic acinien_HK
dc.typeArticleen_HK
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_HK
dc.identifier.authorityBruzzone, R=rp01442en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-5793(88)80989-Xen_HK
dc.identifier.pmid2462514-
dc.identifier.scopuseid_2-s2.0-0024246450en_HK
dc.identifier.volume242en_HK
dc.identifier.issue1en_HK
dc.identifier.spage79en_HK
dc.identifier.epage84en_HK
dc.identifier.isiWOS:A1988R545300016-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridPralong, WF=7004215911en_HK
dc.identifier.scopusauthoridWollheim, CB=7103171309en_HK
dc.identifier.scopusauthoridBruzzone, R=7006793327en_HK

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