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Article: Four novel members of the connexin family of gap junction proteins: Molecular cloning, expression, and chromosome mapping

TitleFour novel members of the connexin family of gap junction proteins: Molecular cloning, expression, and chromosome mapping
Authors
KeywordsMolecular Sequence Numbers
Issue Date1992
PublisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/
Citation
Journal Of Biological Chemistry, 1992, v. 267 n. 3, p. 2057-2064 How to Cite?
AbstractWe have used low stringency hybridization and polymerase chain raction (PCR) amplification with degenerate oligonucleotides to identify four new members of the rat connexin gene family. On the basis of their predicted molecular mass, these proteins have been designated connexin (Cx) 40 (Cx40), Cx37, Cx33, and Cx31.1. The new connexins exhibit all of the conserved structural features of the connexin family, including highly similar extracellular and transmembrane domains but divergent major cytoplasmic domains. On the basis of primary sequence similarity, the connexin family may be divided into two classes. Cx40, Cx37, and Cx33 are similar to the previously characterized Cx43 and Cx46. Cx31.1 is similar to Cx26, Cx31, and Cx32. Cx37 and Cx40 mRNAs are expressed in a wide variety of adult organs and tissues, with particular abundance in lung. However, their relative levels are different in many organs and thus their distribution is not completely coincident. Cx33 and Cx31.1 genes exhibit a much more restricted pattern of expression; mRNAs are detected only in testes and skin, respectively. Chromosomal mapping studies indicate that Cx26 and Cx46 are tightly linked on chromosome 14, and Cx37 and Cx31.1 are linked on chromosome 4, while the rest of the connexin genes are dispersed.
Persistent Identifierhttp://hdl.handle.net/10722/132770
ISSN
2015 Impact Factor: 4.258
2015 SCImago Journal Rankings: 3.151
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHaefliger, JAen_HK
dc.contributor.authorBruzzone, Ren_HK
dc.contributor.authorJenkins, NAen_HK
dc.contributor.authorGilbert, DJen_HK
dc.contributor.authorCopeland, NGen_HK
dc.contributor.authorPaul, DLen_HK
dc.date.accessioned2011-03-28T09:28:52Z-
dc.date.available2011-03-28T09:28:52Z-
dc.date.issued1992en_HK
dc.identifier.citationJournal Of Biological Chemistry, 1992, v. 267 n. 3, p. 2057-2064en_HK
dc.identifier.issn0021-9258en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132770-
dc.description.abstractWe have used low stringency hybridization and polymerase chain raction (PCR) amplification with degenerate oligonucleotides to identify four new members of the rat connexin gene family. On the basis of their predicted molecular mass, these proteins have been designated connexin (Cx) 40 (Cx40), Cx37, Cx33, and Cx31.1. The new connexins exhibit all of the conserved structural features of the connexin family, including highly similar extracellular and transmembrane domains but divergent major cytoplasmic domains. On the basis of primary sequence similarity, the connexin family may be divided into two classes. Cx40, Cx37, and Cx33 are similar to the previously characterized Cx43 and Cx46. Cx31.1 is similar to Cx26, Cx31, and Cx32. Cx37 and Cx40 mRNAs are expressed in a wide variety of adult organs and tissues, with particular abundance in lung. However, their relative levels are different in many organs and thus their distribution is not completely coincident. Cx33 and Cx31.1 genes exhibit a much more restricted pattern of expression; mRNAs are detected only in testes and skin, respectively. Chromosomal mapping studies indicate that Cx26 and Cx46 are tightly linked on chromosome 14, and Cx37 and Cx31.1 are linked on chromosome 4, while the rest of the connexin genes are dispersed.en_HK
dc.languageengen_US
dc.publisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/en_HK
dc.relation.ispartofJournal of Biological Chemistryen_HK
dc.subjectMolecular Sequence Numbersen_US
dc.titleFour novel members of the connexin family of gap junction proteins: Molecular cloning, expression, and chromosome mappingen_HK
dc.typeArticleen_HK
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_HK
dc.identifier.authorityBruzzone, R=rp01442en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1370487-
dc.identifier.scopuseid_2-s2.0-0026541187en_HK
dc.identifier.volume267en_HK
dc.identifier.issue3en_HK
dc.identifier.spage2057en_HK
dc.identifier.epage2064en_HK
dc.identifier.isiWOS:A1992HA48500098-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHaefliger, JA=7004422116en_HK
dc.identifier.scopusauthoridBruzzone, R=7006793327en_HK
dc.identifier.scopusauthoridJenkins, NA=35379887700en_HK
dc.identifier.scopusauthoridGilbert, DJ=7401956091en_HK
dc.identifier.scopusauthoridCopeland, NG=35374759300en_HK
dc.identifier.scopusauthoridPaul, DL=7401667165en_HK

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