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Article: Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins

TitleConnexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1993
PublisherAmerican Society for Cell Biology. The Journal's web site is located at http://www.molbiolcell.org/
Citation
Molecular Biology Of The Cell, 1993, v. 4 n. 1, p. 7-20 How to Cite?
AbstractThe cellular distribution of connexin40 (Cx40), a newly cloned gap junction structural protein, was examined by immunofluorescence microscopy using two different specific anti-peptide antibodies. Cx40 was detected in the endothelium of muscular as well as elastic arteries in a punctate pattern consistent with the known distribution of gap junctions. However, it was not detected in other cells of the vascular wall. By contrast, Cx43, another connexin present in the cardiovascular system, was not detected in endothelial cells of muscular arteries but was abundant in the myocardium and aortic smooth muscle. We have tested the ability of these connexins to interact functionally. Cx40 was functionally expressed in pairs of Xenopus oocytes and induced the formation of intercellular channels with unique voltage dependence. Unexpectedly, communication did not occur when oocytes expressing Cx40 were paired with those expressing Cx43, although each could interact with a different connexin, Cx37, to form gap junction channels in paired oocytes. These findings indicate that establishment of intercellular communication can be spatially regulated by the selective expression of different connexins and suggest a mechanism that may operate to control the extent of communication between cells.
Persistent Identifierhttp://hdl.handle.net/10722/132766
ISSN
2015 Impact Factor: 4.037
2015 SCImago Journal Rankings: 3.665
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBruzzone, Ren_HK
dc.contributor.authorHaefliger, JAen_HK
dc.contributor.authorGimlich, RLen_HK
dc.contributor.authorPaul, DLen_HK
dc.date.accessioned2011-03-28T09:28:50Z-
dc.date.available2011-03-28T09:28:50Z-
dc.date.issued1993en_HK
dc.identifier.citationMolecular Biology Of The Cell, 1993, v. 4 n. 1, p. 7-20en_HK
dc.identifier.issn1059-1524en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132766-
dc.description.abstractThe cellular distribution of connexin40 (Cx40), a newly cloned gap junction structural protein, was examined by immunofluorescence microscopy using two different specific anti-peptide antibodies. Cx40 was detected in the endothelium of muscular as well as elastic arteries in a punctate pattern consistent with the known distribution of gap junctions. However, it was not detected in other cells of the vascular wall. By contrast, Cx43, another connexin present in the cardiovascular system, was not detected in endothelial cells of muscular arteries but was abundant in the myocardium and aortic smooth muscle. We have tested the ability of these connexins to interact functionally. Cx40 was functionally expressed in pairs of Xenopus oocytes and induced the formation of intercellular channels with unique voltage dependence. Unexpectedly, communication did not occur when oocytes expressing Cx40 were paired with those expressing Cx43, although each could interact with a different connexin, Cx37, to form gap junction channels in paired oocytes. These findings indicate that establishment of intercellular communication can be spatially regulated by the selective expression of different connexins and suggest a mechanism that may operate to control the extent of communication between cells.en_HK
dc.languageengen_US
dc.publisherAmerican Society for Cell Biology. The Journal's web site is located at http://www.molbiolcell.org/en_HK
dc.relation.ispartofMolecular Biology of the Cellen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleConnexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexinsen_HK
dc.typeArticleen_HK
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_HK
dc.identifier.authorityBruzzone, R=rp01442en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8382974-
dc.identifier.scopuseid_2-s2.0-0027419412en_HK
dc.identifier.volume4en_HK
dc.identifier.issue1en_HK
dc.identifier.spage7en_HK
dc.identifier.epage20en_HK
dc.identifier.isiWOS:A1993KM25300002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBruzzone, R=7006793327en_HK
dc.identifier.scopusauthoridHaefliger, JA=7004422116en_HK
dc.identifier.scopusauthoridGimlich, RL=6602847860en_HK
dc.identifier.scopusauthoridPaul, DL=7401667165en_HK

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