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Article: The cellular internet: On-line with connexins

TitleThe cellular internet: On-line with connexins
Authors
Issue Date1996
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0265-9247/
Citation
Bioessays, 1996, v. 18 n. 9, p. 709-718 How to Cite?
AbstractMost cells communicate with their immediate neighbors through the exchange of cytosolic molecules such as ions, second messengers and small metabolites. This activity is made possible by clusters of intercellular channels called gap junctions, which connect adjacent cells. In terms of molecular architecture, intercellular channels consist of two channels, called connexons, which interact to span the plasma membranes of two adjacent cells and directly join the cytoplasm of one cell to another. Connexons are made of structural proteins named connexins, which compose a multigene family. Connexin channels participate in the regulation of signaling between developing and differentiated cell types, and recently there have been some unexpected findings. First, unique ionic- and size-selectivities are determined by each connexin; second, the establishment of intercellular communication is defined by the expression of compatible connexins; third, the discovery of connexin mutations associated with human diseases and the study of knockout mice have illustrated the vital role of cell-cell communication in a diverse array of tissue functions.
Persistent Identifierhttp://hdl.handle.net/10722/132745
ISSN
2015 Impact Factor: 4.725
2015 SCImago Journal Rankings: 3.104
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBruzzone, Ren_HK
dc.contributor.authorWhite, TWen_HK
dc.contributor.authorGoodenough, DAen_HK
dc.date.accessioned2011-03-28T09:28:42Z-
dc.date.available2011-03-28T09:28:42Z-
dc.date.issued1996en_HK
dc.identifier.citationBioessays, 1996, v. 18 n. 9, p. 709-718en_HK
dc.identifier.issn0265-9247en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132745-
dc.description.abstractMost cells communicate with their immediate neighbors through the exchange of cytosolic molecules such as ions, second messengers and small metabolites. This activity is made possible by clusters of intercellular channels called gap junctions, which connect adjacent cells. In terms of molecular architecture, intercellular channels consist of two channels, called connexons, which interact to span the plasma membranes of two adjacent cells and directly join the cytoplasm of one cell to another. Connexons are made of structural proteins named connexins, which compose a multigene family. Connexin channels participate in the regulation of signaling between developing and differentiated cell types, and recently there have been some unexpected findings. First, unique ionic- and size-selectivities are determined by each connexin; second, the establishment of intercellular communication is defined by the expression of compatible connexins; third, the discovery of connexin mutations associated with human diseases and the study of knockout mice have illustrated the vital role of cell-cell communication in a diverse array of tissue functions.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0265-9247/en_HK
dc.relation.ispartofBioEssaysen_HK
dc.titleThe cellular internet: On-line with connexinsen_HK
dc.typeArticleen_HK
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_HK
dc.identifier.authorityBruzzone, R=rp01442en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/bies.950180906-
dc.identifier.pmid8831287-
dc.identifier.scopuseid_2-s2.0-0030250207en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030250207&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue9en_HK
dc.identifier.spage709en_HK
dc.identifier.epage718en_HK
dc.identifier.isiWOS:A1996VJ03900005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridBruzzone, R=7006793327en_HK
dc.identifier.scopusauthoridWhite, TW=35499703300en_HK
dc.identifier.scopusauthoridGoodenough, DA=7102378382en_HK

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