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Article: Mini-review: Connexins, gap junctions and cell-cell signalling in the nervous system

TitleMini-review: Connexins, gap junctions and cell-cell signalling in the nervous system
Authors
KeywordsAstrocyte
Channel
Connexon
Neuron
Oligodendrocyte
Issue Date1997
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJN
Citation
European Journal Of Neuroscience, 1997, v. 9 n. 1, p. 1-6 How to Cite?
AbstractConnexins form a multigene family of polytopic membrane proteins that, in vertebrates, are the constitutive subunits of intercellular channels and provide the structural basis for electrical coupling. The appearance of electrical coupling in the nervous system is developmentally regulated and restricted to distinct cell types. Electrical coupling between neurons persists after the establishment of chemical transmission, thus suggesting that this form of cell-cell signalling may be functionally interrelated with, rather than alternative to chemical transmission. Furthermore, evidence for the possible role of gap junctions in human neurological diseases is also mounting, following the discovery that the X-linked form of Charcot-Marie-Tooth syndrome, a demyelinating neuropathy of the peripheral nervous system, is associated with mutations in a connexin gene. These findings raise new questions on the significance of connexin diversity and on their functional role in the nervous system. © European Neuroscience Association.
Persistent Identifierhttp://hdl.handle.net/10722/132736
ISSN
2015 Impact Factor: 2.975
2015 SCImago Journal Rankings: 2.130
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBruzzone, Ren_HK
dc.date.accessioned2011-03-28T09:28:39Z-
dc.date.available2011-03-28T09:28:39Z-
dc.date.issued1997en_HK
dc.identifier.citationEuropean Journal Of Neuroscience, 1997, v. 9 n. 1, p. 1-6en_HK
dc.identifier.issn0953-816Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/132736-
dc.description.abstractConnexins form a multigene family of polytopic membrane proteins that, in vertebrates, are the constitutive subunits of intercellular channels and provide the structural basis for electrical coupling. The appearance of electrical coupling in the nervous system is developmentally regulated and restricted to distinct cell types. Electrical coupling between neurons persists after the establishment of chemical transmission, thus suggesting that this form of cell-cell signalling may be functionally interrelated with, rather than alternative to chemical transmission. Furthermore, evidence for the possible role of gap junctions in human neurological diseases is also mounting, following the discovery that the X-linked form of Charcot-Marie-Tooth syndrome, a demyelinating neuropathy of the peripheral nervous system, is associated with mutations in a connexin gene. These findings raise new questions on the significance of connexin diversity and on their functional role in the nervous system. © European Neuroscience Association.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJNen_HK
dc.relation.ispartofEuropean Journal of Neuroscienceen_HK
dc.subjectAstrocyteen_HK
dc.subjectChannelen_HK
dc.subjectConnexonen_HK
dc.subjectNeuronen_HK
dc.subjectOligodendrocyteen_HK
dc.titleMini-review: Connexins, gap junctions and cell-cell signalling in the nervous systemen_HK
dc.typeArticleen_HK
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_HK
dc.identifier.authorityBruzzone, R=rp01442en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1460-9568.1997.tb01346.x-
dc.identifier.pmid9042562-
dc.identifier.scopuseid_2-s2.0-0031044996en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031044996&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue1en_HK
dc.identifier.spage1en_HK
dc.identifier.epage6en_HK
dc.identifier.isiWOS:A1997WJ17900001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridBruzzone, R=7006793327en_HK

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