File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Intercellular communication in the eye: Clarifying the need for connexin diversity

TitleIntercellular communication in the eye: Clarifying the need for connexin diversity
Authors
KeywordsConnexin diversity
Eye
Intercellular communication
Issue Date2000
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresrev
Citation
Brain Research Reviews, 2000, v. 32 n. 1, p. 130-137 How to Cite?
AbstractIn the vertebrate eye, virtually every cell type is directly coupled to its neighbors by intercellular channels present in gap junctions. Although these structures share the common property of allowing adjacent cells to directly exchange ions, second messengers and small metabolites, intercellular channels in the eye also play a specific role in distinct functions such as neuronal transmission at electrotonic synapses in the retina, and the maintenance of homeostasis in the avascular lens. The structural proteins comprising these channels, the connexins (Cx), are a multigene family of which many members are expressed in the eye, even in the same cell type. This molecular heterogeneity poses the crucial question of whether and how a diversity in gap junctional structural proteins influences intercellular communication in ocular tissues. This review will focus on two recent advances in the understanding of connexin diversity in regard to the eye. First, connexin knockouts have demonstrated that postnatal development and homeostasis in the lens requires multiple connexin proteins. Secondly, functional characterization of new connexins that are abundantly expressed in the retina has revealed biophysical properties that mimic those recorded from retinal neurons. (C) 2000 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/132724
ISSN
2013 Impact Factor: 5.93
2014 SCImago Journal Rankings: 2.982
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWhite, TWen_HK
dc.contributor.authorBruzzone, Ren_HK
dc.date.accessioned2011-03-28T09:28:34Z-
dc.date.available2011-03-28T09:28:34Z-
dc.date.issued2000en_HK
dc.identifier.citationBrain Research Reviews, 2000, v. 32 n. 1, p. 130-137en_HK
dc.identifier.issn0165-0173en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132724-
dc.description.abstractIn the vertebrate eye, virtually every cell type is directly coupled to its neighbors by intercellular channels present in gap junctions. Although these structures share the common property of allowing adjacent cells to directly exchange ions, second messengers and small metabolites, intercellular channels in the eye also play a specific role in distinct functions such as neuronal transmission at electrotonic synapses in the retina, and the maintenance of homeostasis in the avascular lens. The structural proteins comprising these channels, the connexins (Cx), are a multigene family of which many members are expressed in the eye, even in the same cell type. This molecular heterogeneity poses the crucial question of whether and how a diversity in gap junctional structural proteins influences intercellular communication in ocular tissues. This review will focus on two recent advances in the understanding of connexin diversity in regard to the eye. First, connexin knockouts have demonstrated that postnatal development and homeostasis in the lens requires multiple connexin proteins. Secondly, functional characterization of new connexins that are abundantly expressed in the retina has revealed biophysical properties that mimic those recorded from retinal neurons. (C) 2000 Elsevier Science B.V.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresreven_HK
dc.relation.ispartofBrain Research Reviewsen_HK
dc.subjectConnexin diversityen_HK
dc.subjectEyeen_HK
dc.subjectIntercellular communicationen_HK
dc.titleIntercellular communication in the eye: Clarifying the need for connexin diversityen_HK
dc.typeArticleen_HK
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_HK
dc.identifier.authorityBruzzone, R=rp01442en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-0173(99)00072-7en_HK
dc.identifier.pmid10751662-
dc.identifier.scopuseid_2-s2.0-0034077206en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034077206&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue1en_HK
dc.identifier.spage130en_HK
dc.identifier.epage137en_HK
dc.identifier.isiWOS:000087131200015-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridWhite, TW=35499703300en_HK
dc.identifier.scopusauthoridBruzzone, R=7006793327en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats