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Article: Pannexins, a family of gap junction proteins expressed in brain

TitlePannexins, a family of gap junction proteins expressed in brain
Authors
KeywordsSpecies Index: Animalia
Invertebrata
Mammalia
Vertebrata
Issue Date2003
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2003, v. 100 n. 23, p. 13644-13649 How to Cite?
AbstractDatabase search has led to the identification of a family of proteins, the pannexins, which share some structural features with the gap junction forming proteins of invertebrates and vertebrates. The function of these proteins has remained unclear so far. To test the possibility that pannexins underlie electrical communication in the brain, we have investigated their tissue distribution and functional properties. Here, we show that two of these genes, pannexin 1 (Px1) and Px2, are abundantly expressed in the CNS. In many neuronal cell populations, including hippocampus, olfactory bulb, cortex and cerebellum, there is coexpression of both pannexins, whereas in other brain regions, e.g., white matter, only Px1-positive cells were found. On expression in Xenopus oocytes, Px1, but not Px2 forms functional hemichannels. Coinjection of both pannexin RNAs results in hemichannels with functional properties that are different from those formed by Px1 only. In paired oocytes, Px1, alone and in combination with Px2, induces the formation of intercellular channels. The functional characteristics of homomeric Px1 versus heteromeric Px1/Px2 channels and the different expression patterns of Px1 and Px2 in the brain indicate that pannexins form cell type-specific gap junctions with distinct properties that may subserve different functions.
Persistent Identifierhttp://hdl.handle.net/10722/132704
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBruzzone, Ren_HK
dc.contributor.authorHormuzdi, SGen_HK
dc.contributor.authorBarbe, MTen_HK
dc.contributor.authorHerb, Aen_HK
dc.contributor.authorMonyer, Hen_HK
dc.date.accessioned2011-03-28T09:28:24Z-
dc.date.available2011-03-28T09:28:24Z-
dc.date.issued2003en_HK
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2003, v. 100 n. 23, p. 13644-13649en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132704-
dc.description.abstractDatabase search has led to the identification of a family of proteins, the pannexins, which share some structural features with the gap junction forming proteins of invertebrates and vertebrates. The function of these proteins has remained unclear so far. To test the possibility that pannexins underlie electrical communication in the brain, we have investigated their tissue distribution and functional properties. Here, we show that two of these genes, pannexin 1 (Px1) and Px2, are abundantly expressed in the CNS. In many neuronal cell populations, including hippocampus, olfactory bulb, cortex and cerebellum, there is coexpression of both pannexins, whereas in other brain regions, e.g., white matter, only Px1-positive cells were found. On expression in Xenopus oocytes, Px1, but not Px2 forms functional hemichannels. Coinjection of both pannexin RNAs results in hemichannels with functional properties that are different from those formed by Px1 only. In paired oocytes, Px1, alone and in combination with Px2, induces the formation of intercellular channels. The functional characteristics of homomeric Px1 versus heteromeric Px1/Px2 channels and the different expression patterns of Px1 and Px2 in the brain indicate that pannexins form cell type-specific gap junctions with distinct properties that may subserve different functions.en_HK
dc.languageengen_US
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_HK
dc.subjectSpecies Index: Animaliaen_US
dc.subjectInvertebrataen_US
dc.subjectMammaliaen_US
dc.subjectVertebrataen_US
dc.titlePannexins, a family of gap junction proteins expressed in brainen_HK
dc.typeArticleen_HK
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_HK
dc.identifier.authorityBruzzone, R=rp01442en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1073/pnas.2233464100en_HK
dc.identifier.pmid14597722-
dc.identifier.pmcidPMC263867-
dc.identifier.scopuseid_2-s2.0-0345255097en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0345255097&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume100en_HK
dc.identifier.issue23en_HK
dc.identifier.spage13644en_HK
dc.identifier.epage13649en_HK
dc.identifier.isiWOS:000186573700094-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f10001016877-
dc.identifier.scopusauthoridBruzzone, R=7006793327en_HK
dc.identifier.scopusauthoridHormuzdi, SG=6602198230en_HK
dc.identifier.scopusauthoridBarbe, MT=7005131360en_HK
dc.identifier.scopusauthoridHerb, A=6603695962en_HK
dc.identifier.scopusauthoridMonyer, H=35600652500en_HK
dc.identifier.citeulike9487710-

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