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Article: Cell-cell communication beyond connexins: The pannexin channels

TitleCell-cell communication beyond connexins: The pannexin channels
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2006
PublisherAmerican Physiological Society
Citation
Physiology, 2006, v. 21 n. 2, p. 103-114 How to Cite?
AbstractDirect cell-to-cell communication through specialized intercellular channels is a characteristic feature of virtually all multi-cellular organisms. The remarkable functional conservation of cell-to-cell coupling throughout the animal kingdom, however, is not matched at the molecular level of the structural protein components. Thus protostomes (including nematodes and flies) and deuterostomes (including all vertebrates) utilize two unrelated families of gap-junction genes, innexins and connexins, respectively. The recent discovery that pannexins, a novel group of proteins expressed by several organisms, are able to form intercellular channels has started a quest to understand their evolutionary relationship and functional contribution to cell communication in vivo. There are three pannexin genes in mammals, two of which are coexpressed in the developing and adult brain. Of note, pannexin1 can also form Ca 2+-activated hemichannels that open at physiological extracellular Ca2+ concentrations and exhibit distinct pharmacological properties. ©2006 Int. Union Physiol. Sci./Am. Physiol. Soc.
Persistent Identifierhttp://hdl.handle.net/10722/132692
ISSN
2015 Impact Factor: 6.541
2015 SCImago Journal Rankings: 3.190
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBarbe, MTen_HK
dc.contributor.authorMonyer, Hen_HK
dc.contributor.authorBruzzone, Ren_HK
dc.date.accessioned2011-03-28T09:28:17Z-
dc.date.available2011-03-28T09:28:17Z-
dc.date.issued2006en_HK
dc.identifier.citationPhysiology, 2006, v. 21 n. 2, p. 103-114en_HK
dc.identifier.issn1548-9213en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132692-
dc.description.abstractDirect cell-to-cell communication through specialized intercellular channels is a characteristic feature of virtually all multi-cellular organisms. The remarkable functional conservation of cell-to-cell coupling throughout the animal kingdom, however, is not matched at the molecular level of the structural protein components. Thus protostomes (including nematodes and flies) and deuterostomes (including all vertebrates) utilize two unrelated families of gap-junction genes, innexins and connexins, respectively. The recent discovery that pannexins, a novel group of proteins expressed by several organisms, are able to form intercellular channels has started a quest to understand their evolutionary relationship and functional contribution to cell communication in vivo. There are three pannexin genes in mammals, two of which are coexpressed in the developing and adult brain. Of note, pannexin1 can also form Ca 2+-activated hemichannels that open at physiological extracellular Ca2+ concentrations and exhibit distinct pharmacological properties. ©2006 Int. Union Physiol. Sci./Am. Physiol. Soc.en_HK
dc.languageengen_US
dc.publisherAmerican Physiological Societyen_US
dc.relation.ispartofPhysiologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleCell-cell communication beyond connexins: The pannexin channelsen_HK
dc.typeArticleen_HK
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_HK
dc.identifier.authorityBruzzone, R=rp01442en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1152/physiol.00048.2005en_HK
dc.identifier.pmid16565476en_HK
dc.identifier.scopuseid_2-s2.0-33646738415en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646738415&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue2en_HK
dc.identifier.spage103en_HK
dc.identifier.epage114en_HK
dc.identifier.isiWOS:000236822000004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBarbe, MT=7005131360en_HK
dc.identifier.scopusauthoridMonyer, H=35600652500en_HK
dc.identifier.scopusauthoridBruzzone, R=7006793327en_HK

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