File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Structure and function of gap junctions in the developing brain

TitleStructure and function of gap junctions in the developing brain
Authors
KeywordsBrain development
Gap junction
Hemichannels
Pannexins
Prenatal neurogenesis
Issue Date2006
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htm
Citation
Cell And Tissue Research, 2006, v. 326 n. 2, p. 239-248 How to Cite?
AbstractGap-junction-dependent neuronal communication is widespread in the developing brain, and the prevalence of gap-junctional coupling is well correlated with specific developmental events. We summarize here our current knowledge of the contribution of gap junctions to brain development and propose that they carry out this role by taking advantage of the full complement of their functional properties. Thus, hemichannel activation may represent a key step in the initiation of Ca 2+ waves that coordinate cell cycle events during early prenatal neurogenesis, whereas both hemichannels and/or gap junctions may control the division and migration of cohorts of precusor cells during late prenatal neurogenesis. Finally, the recent discovery that pannexins, a novel group of proteins prominently expressed in the brain, are able to form both hemichannels and gap-junction channels suggests that we need to seek more than just connexins with respect to these junctions. © Springer-Verlag 2006.
Persistent Identifierhttp://hdl.handle.net/10722/132690
ISSN
2015 Impact Factor: 2.948
2015 SCImago Journal Rankings: 1.539
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBruzzone, Ren_HK
dc.contributor.authorDermietzel, Ren_HK
dc.date.accessioned2011-03-28T09:28:16Z-
dc.date.available2011-03-28T09:28:16Z-
dc.date.issued2006en_HK
dc.identifier.citationCell And Tissue Research, 2006, v. 326 n. 2, p. 239-248en_HK
dc.identifier.issn0302-766Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/132690-
dc.description.abstractGap-junction-dependent neuronal communication is widespread in the developing brain, and the prevalence of gap-junctional coupling is well correlated with specific developmental events. We summarize here our current knowledge of the contribution of gap junctions to brain development and propose that they carry out this role by taking advantage of the full complement of their functional properties. Thus, hemichannel activation may represent a key step in the initiation of Ca 2+ waves that coordinate cell cycle events during early prenatal neurogenesis, whereas both hemichannels and/or gap junctions may control the division and migration of cohorts of precusor cells during late prenatal neurogenesis. Finally, the recent discovery that pannexins, a novel group of proteins prominently expressed in the brain, are able to form both hemichannels and gap-junction channels suggests that we need to seek more than just connexins with respect to these junctions. © Springer-Verlag 2006.en_HK
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00441/index.htmen_HK
dc.relation.ispartofCell and Tissue Researchen_HK
dc.subjectBrain developmenten_HK
dc.subjectGap junctionen_HK
dc.subjectHemichannelsen_HK
dc.subjectPannexinsen_HK
dc.subjectPrenatal neurogenesisen_HK
dc.titleStructure and function of gap junctions in the developing brainen_HK
dc.typeArticleen_HK
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_HK
dc.identifier.authorityBruzzone, R=rp01442en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00441-006-0287-0en_HK
dc.identifier.pmid16896946-
dc.identifier.scopuseid_2-s2.0-33748936354en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33748936354&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume326en_HK
dc.identifier.issue2en_HK
dc.identifier.spage239en_HK
dc.identifier.epage248en_HK
dc.identifier.isiWOS:000240714000005-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridBruzzone, R=7006793327en_HK
dc.identifier.scopusauthoridDermietzel, R=7005778543en_HK
dc.identifier.citeulike1020213-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats