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Article: Glucose-insulin interactions on exocrine secretion from the perfused rat pancreas

TitleGlucose-insulin interactions on exocrine secretion from the perfused rat pancreas
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1984
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Gastroenterology, 1984, v. 87 n. 6, p. 1304-1312 How to Cite?
AbstractThe effects of glucose and insulin on pancreatic enzyme release have been investigated using the isolated perfused rat pancreas. Basal and caerulein-stimulated secretion was significantly less in the presence of 15 mM glucose than with 5 mM glucose, except at a supramaximal concentration of caerulein (10 -9 M) where secretion was similar in both groups. Addition of exogenous insulin also caused a reduction in enzyme secretion, but the time of onset of the inhibitory action was delayed compared to that observed with glucose. Furthermore, it was found that the effects of 15 mM glucose and exogenous insulin were not additive at the concentration used in these experiments, and that the inhibitory action of insulin was glucose-dependent. Such glucose-insulin interactions must play an important role in the modulation of pancreatic enzyme secretion.
Persistent Identifierhttp://hdl.handle.net/10722/132687
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBruzzone, Ren_HK
dc.contributor.authorTrimble, ERen_HK
dc.contributor.authorGjinovci, Aen_HK
dc.contributor.authorRenold, AEen_HK
dc.date.accessioned2011-03-28T09:28:14Z-
dc.date.available2011-03-28T09:28:14Z-
dc.date.issued1984en_HK
dc.identifier.citationGastroenterology, 1984, v. 87 n. 6, p. 1304-1312en_HK
dc.identifier.issn0016-5085en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132687-
dc.description.abstractThe effects of glucose and insulin on pancreatic enzyme release have been investigated using the isolated perfused rat pancreas. Basal and caerulein-stimulated secretion was significantly less in the presence of 15 mM glucose than with 5 mM glucose, except at a supramaximal concentration of caerulein (10 -9 M) where secretion was similar in both groups. Addition of exogenous insulin also caused a reduction in enzyme secretion, but the time of onset of the inhibitory action was delayed compared to that observed with glucose. Furthermore, it was found that the effects of 15 mM glucose and exogenous insulin were not additive at the concentration used in these experiments, and that the inhibitory action of insulin was glucose-dependent. Such glucose-insulin interactions must play an important role in the modulation of pancreatic enzyme secretion.en_HK
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_HK
dc.relation.ispartofGastroenterologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleGlucose-insulin interactions on exocrine secretion from the perfused rat pancreasen_HK
dc.typeArticleen_US
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_HK
dc.identifier.authorityBruzzone, R=rp01442en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6208076-
dc.identifier.scopuseid_2-s2.0-0021631614en_HK
dc.identifier.volume87en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1304en_HK
dc.identifier.epage1312en_HK
dc.identifier.isiWOS:A1984TS37300014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBruzzone, R=7006793327en_HK
dc.identifier.scopusauthoridTrimble, ER=7005267920en_HK
dc.identifier.scopusauthoridGjinovci, A=6701391657en_HK
dc.identifier.scopusauthoridRenold, AE=7005742513en_HK

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