Article: Abnormalities of caerulein- and carbamylcholine-stimulated pancreatic enzyme secretion in the obese Zucker rat

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Scopus: eid_2-s2.0-0021854677
PMID: 2414827

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Title	Abnormalities of caerulein- and carbamylcholine-stimulated pancreatic enzyme secretion in the obese Zucker rat
Authors	Trimble, ER1 Bruzzone, R1
Keywords	Chemicals And Cas Registry Numbers
Issue Date	1985
Publisher	Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/regpep
Citation	Regulatory Peptides, 1985, v. 11 n. 3, p. 227-235 [How to Cite?] DOI: http://dx.doi.org/10.1016/0167-0115(85)90054-0
Abstract	The secretory function of the exocrine pancreas has been studied in dispersed pancreatic acini from obese and homozygous lean Zucker rats at 6 and 22 wk. No abnormality was found in acini from young rats. Acini from 22 wk obese and lean rats were equally responsive to secretagogues which stimulate cAMP, i.e. vasoactive intestinal peptide (VIP) and secretin. By contrast, there was a reduction in the maximum responsiveness to caerulein and carbamylcholine in acini from obese rats. These latter secretagogues act through mobilization of intracellular Ca 2+. Since obese animals are insulin resistant and amylase release is modulated by insulin, the role of insulin resistance in the secretory defect was then investigated. A group of 22 wk obese rats received treatment with Ciglitazone (a drug which reduces insulin resistance in obese laboratory animals) for 4 wk before the secretion study. Despite the expected reduction in insulin resistance there was no improvement of the secretory defect seen with caerulein and carbamylcholine stimulation. Thus, the secretory abnormality in the exocrine pancreas of adult obese Zucker rats does not appear to be directly associated with insulin resistance. Furthermore, the secretory defect is linked to those secretagogues which induce Ca 2+-independent phosphoinositide hydrolysis and Ca 2+ mobilization in the target cell.
ISSN	0167-0115 2011 Impact Factor: 2.11 2011 SCImago Journal Rankings: 0.167
DOI	http://dx.doi.org/10.1016/0167-0115(85)90054-0
ISI Accession Number ID	WOS:A1985ANZ9300006

DC Field	Value
dc.contributor.author	Trimble, ER
dc.contributor.author	Bruzzone, R
dc.date.accessioned	2011-03-28T09:28:14Z
dc.date.available	2011-03-28T09:28:14Z
dc.date.issued	1985
dc.description.abstract	The secretory function of the exocrine pancreas has been studied in dispersed pancreatic acini from obese and homozygous lean Zucker rats at 6 and 22 wk. No abnormality was found in acini from young rats. Acini from 22 wk obese and lean rats were equally responsive to secretagogues which stimulate cAMP, i.e. vasoactive intestinal peptide (VIP) and secretin. By contrast, there was a reduction in the maximum responsiveness to caerulein and carbamylcholine in acini from obese rats. These latter secretagogues act through mobilization of intracellular Ca 2+. Since obese animals are insulin resistant and amylase release is modulated by insulin, the role of insulin resistance in the secretory defect was then investigated. A group of 22 wk obese rats received treatment with Ciglitazone (a drug which reduces insulin resistance in obese laboratory animals) for 4 wk before the secretion study. Despite the expected reduction in insulin resistance there was no improvement of the secretory defect seen with caerulein and carbamylcholine stimulation. Thus, the secretory abnormality in the exocrine pancreas of adult obese Zucker rats does not appear to be directly associated with insulin resistance. Furthermore, the secretory defect is linked to those secretagogues which induce Ca 2+-independent phosphoinositide hydrolysis and Ca 2+ mobilization in the target cell.
dc.description.nature	link_to_subscribed_fulltext
dc.identifier.citation	Regulatory Peptides, 1985, v. 11 n. 3, p. 227-235 [How to Cite?] DOI: http://dx.doi.org/10.1016/0167-0115(85)90054-0
dc.identifier.doi	http://dx.doi.org/10.1016/0167-0115(85)90054-0
dc.identifier.epage	235
dc.identifier.isi	WOS:A1985ANZ9300006
dc.identifier.issn	0167-0115 2011 Impact Factor: 2.11 2011 SCImago Journal Rankings: 0.167
dc.identifier.issue	3
dc.identifier.pmid	2414827
dc.identifier.scopus	eid_2-s2.0-0021854677
dc.identifier.spage	227
dc.identifier.uri	http://hdl.handle.net/10722/132685
dc.identifier.volume	11
dc.language	eng
dc.publisher	Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/regpep
dc.publisher.place	Netherlands
dc.relation.ispartof	Regulatory Peptides
dc.subject	Chemicals And Cas Registry Numbers
dc.title	Abnormalities of caerulein- and carbamylcholine-stimulated pancreatic enzyme secretion in the obese Zucker rat
dc.type	Article

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Université de Genève Faculté de Médecine

Article: Abnormalities of caerulein- and carbamylcholine-stimulated pancreatic enzyme secretion in the obese Zucker rat

The HKU Scholars Hub has contact details for these author(s).