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Article: Abnormalities of caerulein- and carbamylcholine-stimulated pancreatic enzyme secretion in the obese Zucker rat

TitleAbnormalities of caerulein- and carbamylcholine-stimulated pancreatic enzyme secretion in the obese Zucker rat
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1985
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/regpep
Citation
Regulatory Peptides, 1985, v. 11 n. 3, p. 227-235 How to Cite?
AbstractThe secretory function of the exocrine pancreas has been studied in dispersed pancreatic acini from obese and homozygous lean Zucker rats at 6 and 22 wk. No abnormality was found in acini from young rats. Acini from 22 wk obese and lean rats were equally responsive to secretagogues which stimulate cAMP, i.e. vasoactive intestinal peptide (VIP) and secretin. By contrast, there was a reduction in the maximum responsiveness to caerulein and carbamylcholine in acini from obese rats. These latter secretagogues act through mobilization of intracellular Ca 2+. Since obese animals are insulin resistant and amylase release is modulated by insulin, the role of insulin resistance in the secretory defect was then investigated. A group of 22 wk obese rats received treatment with Ciglitazone (a drug which reduces insulin resistance in obese laboratory animals) for 4 wk before the secretion study. Despite the expected reduction in insulin resistance there was no improvement of the secretory defect seen with caerulein and carbamylcholine stimulation. Thus, the secretory abnormality in the exocrine pancreas of adult obese Zucker rats does not appear to be directly associated with insulin resistance. Furthermore, the secretory defect is linked to those secretagogues which induce Ca 2+-independent phosphoinositide hydrolysis and Ca 2+ mobilization in the target cell.
Persistent Identifierhttp://hdl.handle.net/10722/132685
ISSN
2014 Impact Factor: 1.833
2013 SCImago Journal Rankings: 0.848
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTrimble, ERen_HK
dc.contributor.authorBruzzone, Ren_HK
dc.date.accessioned2011-03-28T09:28:14Z-
dc.date.available2011-03-28T09:28:14Z-
dc.date.issued1985en_HK
dc.identifier.citationRegulatory Peptides, 1985, v. 11 n. 3, p. 227-235en_HK
dc.identifier.issn0167-0115en_HK
dc.identifier.urihttp://hdl.handle.net/10722/132685-
dc.description.abstractThe secretory function of the exocrine pancreas has been studied in dispersed pancreatic acini from obese and homozygous lean Zucker rats at 6 and 22 wk. No abnormality was found in acini from young rats. Acini from 22 wk obese and lean rats were equally responsive to secretagogues which stimulate cAMP, i.e. vasoactive intestinal peptide (VIP) and secretin. By contrast, there was a reduction in the maximum responsiveness to caerulein and carbamylcholine in acini from obese rats. These latter secretagogues act through mobilization of intracellular Ca 2+. Since obese animals are insulin resistant and amylase release is modulated by insulin, the role of insulin resistance in the secretory defect was then investigated. A group of 22 wk obese rats received treatment with Ciglitazone (a drug which reduces insulin resistance in obese laboratory animals) for 4 wk before the secretion study. Despite the expected reduction in insulin resistance there was no improvement of the secretory defect seen with caerulein and carbamylcholine stimulation. Thus, the secretory abnormality in the exocrine pancreas of adult obese Zucker rats does not appear to be directly associated with insulin resistance. Furthermore, the secretory defect is linked to those secretagogues which induce Ca 2+-independent phosphoinositide hydrolysis and Ca 2+ mobilization in the target cell.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/regpepen_HK
dc.relation.ispartofRegulatory Peptidesen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleAbnormalities of caerulein- and carbamylcholine-stimulated pancreatic enzyme secretion in the obese Zucker raten_HK
dc.typeArticleen_HK
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_HK
dc.identifier.authorityBruzzone, R=rp01442en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0167-0115(85)90054-0en_HK
dc.identifier.pmid2414827en_HK
dc.identifier.scopuseid_2-s2.0-0021854677en_HK
dc.identifier.volume11en_HK
dc.identifier.issue3en_HK
dc.identifier.spage227en_HK
dc.identifier.epage235en_HK
dc.identifier.isiWOS:A1985ANZ9300006-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridTrimble, ER=7005267920en_HK
dc.identifier.scopusauthoridBruzzone, R=7006793327en_HK

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