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Article: Abnormalities of caerulein- and carbamylcholine-stimulated pancreatic enzyme secretion in the obese Zucker rat
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TitleAbnormalities of caerulein- and carbamylcholine-stimulated pancreatic enzyme secretion in the obese Zucker rat
 
AuthorsTrimble, ER1
Bruzzone, R1
 
KeywordsChemicals And Cas Registry Numbers
 
Issue Date1985
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/regpep
 
CitationRegulatory Peptides, 1985, v. 11 n. 3, p. 227-235 [How to Cite?]
DOI: http://dx.doi.org/10.1016/0167-0115(85)90054-0
 
AbstractThe secretory function of the exocrine pancreas has been studied in dispersed pancreatic acini from obese and homozygous lean Zucker rats at 6 and 22 wk. No abnormality was found in acini from young rats. Acini from 22 wk obese and lean rats were equally responsive to secretagogues which stimulate cAMP, i.e. vasoactive intestinal peptide (VIP) and secretin. By contrast, there was a reduction in the maximum responsiveness to caerulein and carbamylcholine in acini from obese rats. These latter secretagogues act through mobilization of intracellular Ca 2+. Since obese animals are insulin resistant and amylase release is modulated by insulin, the role of insulin resistance in the secretory defect was then investigated. A group of 22 wk obese rats received treatment with Ciglitazone (a drug which reduces insulin resistance in obese laboratory animals) for 4 wk before the secretion study. Despite the expected reduction in insulin resistance there was no improvement of the secretory defect seen with caerulein and carbamylcholine stimulation. Thus, the secretory abnormality in the exocrine pancreas of adult obese Zucker rats does not appear to be directly associated with insulin resistance. Furthermore, the secretory defect is linked to those secretagogues which induce Ca 2+-independent phosphoinositide hydrolysis and Ca 2+ mobilization in the target cell.
 
ISSN0167-0115
2013 Impact Factor: 2.014
2013 SCImago Journal Rankings: 0.848
 
DOIhttp://dx.doi.org/10.1016/0167-0115(85)90054-0
 
ISI Accession Number IDWOS:A1985ANZ9300006
 
DC FieldValue
dc.contributor.authorTrimble, ER
 
dc.contributor.authorBruzzone, R
 
dc.date.accessioned2011-03-28T09:28:14Z
 
dc.date.available2011-03-28T09:28:14Z
 
dc.date.issued1985
 
dc.description.abstractThe secretory function of the exocrine pancreas has been studied in dispersed pancreatic acini from obese and homozygous lean Zucker rats at 6 and 22 wk. No abnormality was found in acini from young rats. Acini from 22 wk obese and lean rats were equally responsive to secretagogues which stimulate cAMP, i.e. vasoactive intestinal peptide (VIP) and secretin. By contrast, there was a reduction in the maximum responsiveness to caerulein and carbamylcholine in acini from obese rats. These latter secretagogues act through mobilization of intracellular Ca 2+. Since obese animals are insulin resistant and amylase release is modulated by insulin, the role of insulin resistance in the secretory defect was then investigated. A group of 22 wk obese rats received treatment with Ciglitazone (a drug which reduces insulin resistance in obese laboratory animals) for 4 wk before the secretion study. Despite the expected reduction in insulin resistance there was no improvement of the secretory defect seen with caerulein and carbamylcholine stimulation. Thus, the secretory abnormality in the exocrine pancreas of adult obese Zucker rats does not appear to be directly associated with insulin resistance. Furthermore, the secretory defect is linked to those secretagogues which induce Ca 2+-independent phosphoinositide hydrolysis and Ca 2+ mobilization in the target cell.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationRegulatory Peptides, 1985, v. 11 n. 3, p. 227-235 [How to Cite?]
DOI: http://dx.doi.org/10.1016/0167-0115(85)90054-0
 
dc.identifier.doihttp://dx.doi.org/10.1016/0167-0115(85)90054-0
 
dc.identifier.epage235
 
dc.identifier.isiWOS:A1985ANZ9300006
 
dc.identifier.issn0167-0115
2013 Impact Factor: 2.014
2013 SCImago Journal Rankings: 0.848
 
dc.identifier.issue3
 
dc.identifier.pmid2414827
 
dc.identifier.scopuseid_2-s2.0-0021854677
 
dc.identifier.spage227
 
dc.identifier.urihttp://hdl.handle.net/10722/132685
 
dc.identifier.volume11
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/regpep
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofRegulatory Peptides
 
dc.subjectChemicals And Cas Registry Numbers
 
dc.titleAbnormalities of caerulein- and carbamylcholine-stimulated pancreatic enzyme secretion in the obese Zucker rat
 
dc.typeArticle
 
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Author Affiliations
  1. Université de Genève Faculté de Médecine